Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Ryan T Kelly"'
Autor:
Ying Zhu, Mirko Scheibinger, Daniel Christian Ellwanger, Jocelyn F Krey, Dongseok Choi, Ryan T Kelly, Stefan Heller, Peter G Barr-Gillespie
Publikováno v:
eLife, Vol 8 (2019)
Hearing and balance rely on small sensory hair cells that reside in the inner ear. To explore dynamic changes in the abundant proteins present in differentiating hair cells, we used nanoliter-scale shotgun mass spectrometry of single cells, each ~1 p
Externí odkaz:
https://doaj.org/article/19e6a3669263492e9fe408c93b8d336a
Autor:
Amanda J. Guise, Santosh A. Misal, Richard Carson, Jen-Hwa Chu, Hannah Boekweg, Daisha Van Der Watt, Nora C. Welsh, Thy Truong, Yiran Liang, Shanqin Xu, Gina Benedetto, Jake Gagnon, Samuel H. Payne, Edward D. Plowey, Ryan T. Kelly
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113636- (2024)
Summary: A limitation of conventional bulk-tissue proteome studies in amyotrophic lateral sclerosis (ALS) is the confounding of motor neuron (MN) signals by admixed non-MN proteins. Here, we leverage laser capture microdissection and nanoPOTS single-
Externí odkaz:
https://doaj.org/article/8a6acb1de53f412fbde8d06f4b44f6e9
Autor:
Paul D. Piehowski, Ying Zhu, Lisa M. Bramer, Kelly G. Stratton, Rui Zhao, Daniel J. Orton, Ronald J. Moore, Jia Yuan, Hugh D. Mitchell, Yuqian Gao, Bobbie-Jo M. Webb-Robertson, Sudhansu K. Dey, Ryan T. Kelly, Kristin E. Burnum-Johnson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Imaging mass spectrometry is a powerful emerging tool for mapping the spatial distribution of biomolecules across tissue surfaces. Here the authors showcase an automated technology for deep proteome imaging that utilizes ultrasensitive microfluidics
Externí odkaz:
https://doaj.org/article/e3b5a3a1d7b147dd83097e22370e56dc
Autor:
Yiran Liang, Thy Truong, Aubrianna J. Saxton, Hannah Boekweg, Samuel H. Payne, Pam M. Van Ry, Ryan T. Kelly
Publikováno v:
Analytical Chemistry. 95:8020-8027
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f7f843c7a60f7a61d2aa2c0ab012228
https://doi.org/10.1021/acs.analchem.3c00906
https://doi.org/10.1021/acs.analchem.3c00906
Autor:
Ying Zhu, Paul D. Piehowski, Rui Zhao, Jing Chen, Yufeng Shen, Ronald J. Moore, Anil K. Shukla, Vladislav A. Petyuk, Martha Campbell-Thompson, Clayton E. Mathews, Richard D. Smith, Wei-Jun Qian, Ryan T. Kelly
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
There is a great need of developing highly sensitive mass spectrometry-based proteomics analysis for small cell populations. Here, the authors establish a robotically controlled chip-based nanodroplet processing platform and demonstrate its ability t
Externí odkaz:
https://doaj.org/article/275e69e5c58341579e052e295934e528
Autor:
Andikan J. Nwosu, Santosh A. Misal, Thy Truong, Richard H. Carson, Kei G. I. Webber, Nathaniel B. Axtell, Yiran Liang, S. Madisyn Johnston, Kenneth L. Virgin, Ethan G. Smith, George V. Thomas, Terry Morgan, John C. Price, Ryan T. Kelly
Publikováno v:
J Proteome Res
Formalin-fixed, paraffin-embedded (FFPE) tissues are banked in large repositories to cost-effectively preserve valuable specimens for later study. With the rapid growth of spatial proteomics, FFPE tissues can serve as a more accessible alternative to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5e491284f556ea65be1cc478ed02c5
https://doi.org/10.1021/acs.jproteome.2c00409
https://doi.org/10.1021/acs.jproteome.2c00409
Autor:
Azad Eshghi, Xiaofeng Xie, Darryl Hardie, Michael X. Chen, Fabiana Izaguirre, Rachael Newman, Ying Zhu, Ryan T. Kelly, David R. Goodlett
Publikováno v:
Journal of Proteome Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68375735b29a944778c6994488a1a3f7
https://doi.org/10.1021/acs.jproteome.2c00429
https://doi.org/10.1021/acs.jproteome.2c00429
Autor:
Laurent Gatto, Ruedi Aebersold, Juergen Cox, Vadim Demichev, Jason Derks, Edward Emmott, Alexander M. Franks, Alexander R. Ivanov, Ryan T. Kelly, Luke Khoury, Andrew Leduc, Michael J. MacCoss, Peter Nemes, David H. Perlman, Aleksandra A. Petelski, Christopher M. Rose, Erwin M. Schoof, Jennifer Van Eyk, Christophe Vanderaa, John R. Yates, Nikolai Slavov
Publikováno v:
Nature Methods, Vol. 20, no.3, p. 375-386 (2023)
Nat Methods
Nat Methods
Analyzing proteins from single cells by tandem mass spectrometry (MS) has become technically feasible. While such analysis has the potential to accurately quantify thousands of proteins across thousands of single cells, the accuracy and reproducibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffcf2355b99e372fc841c11cdcc6592
https://hdl.handle.net/2078.1/273466
https://hdl.handle.net/2078.1/273466
Autor:
Hannah Boekweg, Daisha Van Der Watt, Thy Truong, S. Madisyn Johnston, Amanda J. Guise, Edward D. Plowey, Ryan T. Kelly, Samuel H. Payne
Publikováno v:
Journal of Proteome Research. 21:182-188
The goal of proteomics is to identify and quantify the complete set of proteins in a biological sample. Single-cell proteomics specializes in the identification and quantitation of proteins for individual cells, often used to elucidate cellular heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9399771e2229efa53e8b4007a487d0
https://doi.org/10.1021/acs.jproteome.1c00670
https://doi.org/10.1021/acs.jproteome.1c00670
Publikováno v:
J Proteome Res
Multimodal mass spectrometry imaging (MSI) is a critical technique used for deeply investigating biological systems by combining multiple MSI platforms in order to gain the maximum molecular information about a sample that would otherwise be limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4e9b86ddca3a7c128dbae9ba19d2de
https://doi.org/10.1021/acs.jproteome.1c00641
https://doi.org/10.1021/acs.jproteome.1c00641