A neuronal signature for monogamous reunion

Autor: Eric J. Klein, Eric A. Vance, Mazen A. Kheirbek, Elliott Saslow, Jessica C. Jimenez, Ryan T. Cameron, Jennifer L. Scribner, William M. Sheeran, David S.W. Protter, Zoe R. Donaldson

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 20

Pair bond formation depends vitally on neuromodulatory signaling within the nucleus accumbens, but the neuronal dynamics underlying this behavior remain unclear. Using in vivo Ca2+ imaging in monogamous prairie voles, we found that pair bonding does

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0549062176523f3294bad02f1429fd32
https://doi.org/10.1073/pnas.1917287117

Emergent intra-pair sex differences and behavioral coordination in pair bonded prairie voles

Autor: Liza E. Brusman, Zoe R. Donaldson, Gabriel D. Chapel, Ryan T. Cameron, Isaiah O. Elges, Annaliese K. Beery, David S.W. Protter, Allison C. Fultz, Maya U. Paulson

In pair bonding animals, coordinated behavior between partners is required for the pair to accomplish shared goals such as raising young. Despite this, experimental designs rarely assess the behavior of both partners within a bonded pair. Thus, we la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf30a4bcaac21fe52455185976c7730a
https://doi.org/10.1101/2021.09.03.458892

Increase in Ca2+ current by sustained cAMP levels enhances proliferation rate in GH3 cells

Autor: Paulo S.L. Beirão, Marcella Brescia, Andréia Laura Rodrigues, George S. Baillie, Thaís Helena Moreira, Ryan T. Cameron, Jader S. Cruz, Andreas Koschinski, Manuela Zaccolo

Aims: \ud Ca2 + and cAMP are important intracellular modulators. In order to generate intracellular signals with various amplitudes, as well as different temporal and spatial properties, a tightly and precise control of these modulators in intracellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3405a832b5759bd6bcf8049a7921dfd
https://eprints.gla.ac.uk/153354/1/153354.pdf

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

Autor: Gemma L. Baillie, Alison Porter, Stuart P. McElroy, Ryan T. Cameron, George S. Baillie, Andreas Koschinski, Euan Parnell, Manuela Zaccolo, Stephen J. Yarwood

Publikováno v: Biochimica et Biophysica Acta

Recent studies have demonstrated that the actin binding protein, ezrin, and the cAMP-sensor, EPAC1, cooperate to induce cell spreading in response to elevations in intracellular cAMP. To investigate the mechanisms underlying these effects we generate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445d2281d8765cd3d82eb91fae61ae3d

Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)

Autor: George S. Baillie, Miles D. Houslay, Krishna C. Yalla, David R. Adams, Brian K. Shoichet, Ryan T. Cameron, Jon P. Day, Ryan G. Coleman

Publikováno v: Biochemical Pharmacology

Graphical abstract
PDE4 is one of eleven known cyclic nucleotide phosphodiesterase families and plays a pivotal role in mediating hydrolytic degradation of the important cyclic nucleotide second messenger, cyclic 3′5′ adenosine monophosphate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d304597df6e5e62cdf25046714a43ac
https://doi.org/10.1016/j.bcp.2013.02.026