Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ryan Sowell"'
Autor:
S. N. Gettinger, J. Choi, N. Mani, M. F. Sanmamed, I. Datar, Ryan Sowell, Victor Y. Du, E. Kaftan, S. Goldberg, W. Dong, D. Zelterman, K. Politi, P. Kavathas, S. Kaech, X. Yu, H. Zhao, J. Schlessinger, R. Lifton, D. L. Rimm, L. Chen, R. S. Herbst, K. A. Schalper
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Immune checkpoint blockade (ICB) only induces tumour response in a subset of non-small cell lung carcinomas (NSCLC). Here the authors do whole genome sequencing and multiplexed quantitative immunofluorescence on patient samples and identify a “dorm
Externí odkaz:
https://doaj.org/article/c6ec06496e454ad4bab2a7a08fce84f1
Autor:
Katerina Politi, Roy S. Herbst, Kurt Schalper, Susan M. Kaech, David L. Rimm, Paula Kavathas, Soldano Ferrone, Richard Lifton, Luis M. Montuenga, Jackeline Agorreta, Ignacio Melero, Miguel F. Sanmamed, Anne Chiang, Sarah B. Goldberg, Joseph Schlessinger, Victor Y. Du, Mary Ann Melnick, Guoping Cai, Weilai Dong, Anna Wurtz, Ryan Sowell, Ila Datar, Anna Truini, Katherine Hastings, Jungmin Choi, Scott Gettinger
Table with Details of Patient Characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7db4d6d12723636f1cc30f480647eaf
https://doi.org/10.1158/2159-8290.22532594
https://doi.org/10.1158/2159-8290.22532594
Autor:
Katerina Politi, Roy S. Herbst, Kurt Schalper, Susan M. Kaech, David L. Rimm, Paula Kavathas, Soldano Ferrone, Richard Lifton, Luis M. Montuenga, Jackeline Agorreta, Ignacio Melero, Miguel F. Sanmamed, Anne Chiang, Sarah B. Goldberg, Joseph Schlessinger, Victor Y. Du, Mary Ann Melnick, Guoping Cai, Weilai Dong, Anna Wurtz, Ryan Sowell, Ila Datar, Anna Truini, Katherine Hastings, Jungmin Choi, Scott Gettinger
Methods for quantitative immunofluorescence and IFN gamma treatment of PDXs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0eaf290750aeb1b8c07b3c8a19acefb
https://doi.org/10.1158/2159-8290.22532597
https://doi.org/10.1158/2159-8290.22532597
Autor:
Katerina Politi, Roy S. Herbst, Kurt Schalper, Susan M. Kaech, David L. Rimm, Paula Kavathas, Soldano Ferrone, Richard Lifton, Luis M. Montuenga, Jackeline Agorreta, Ignacio Melero, Miguel F. Sanmamed, Anne Chiang, Sarah B. Goldberg, Joseph Schlessinger, Victor Y. Du, Mary Ann Melnick, Guoping Cai, Weilai Dong, Anna Wurtz, Ryan Sowell, Ila Datar, Anna Truini, Katherine Hastings, Jungmin Choi, Scott Gettinger
Supplementary Figures S1-S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11841c2b8e856fa8f157291f1150396e
https://doi.org/10.1158/2159-8290.22532600.v1
https://doi.org/10.1158/2159-8290.22532600.v1
Publikováno v:
The Journal of Immunology. 194:66.8-66.8
Memory CD8 T cells comprise niches of circulating cells and non-circulating tissue residents. The localization of memory cells defines phenotypic and functionally distinct populations. However, the mechanisms that direct tissue-specific T cell respon
Publikováno v:
The Journal of Immunology. 192:191.6-191.6
Mucosal tissues are sites of frequent pathogen exposure and major routes for the transmission of infectious diseases. Migration of virus-specific memory CD8 T cells into mucosal tissues such as the small intestine and vaginal mucosa is highly restric
Publikováno v:
The Journal of Immunology. 192:65.12-65.12
Inhibition of the mTOR pathway with the pharmacological inhibitor rapamycin, can enhance the formation of virus-specific memory CD8 T cells. While mTOR signals through two separate protein complexes, mTORC1 and mTORC2 the role of each in memory CD8 T
Publikováno v:
The Journal of Immunology. 190:171.23-171.23
Mucosal tissues are sites of frequent pathogen exposure and major routes for the transmission of infectious diseases. Migration of virus-specific memory CD8 T cells into mucosal tissues such as the small intestine and vaginal mucosa is highly restric
Publikováno v:
The Journal of Immunology. 186:46.23-46.23
A limitation of current vaccine strategies is the inability to generate effective memory CD8 T cell responses in locations relevant to disease transmission. There is a gap in our knowledge of how memory CD8 T cells are generated and maintained in viv
Publikováno v:
The Journal of Immunology. 186:46.5-46.5
Given that CD4 T cells are targets of depletion by HIV and required for the homing capacity of CD8 T cells, enhancing recruitment of both CD4 and CD8’s could potentially enhance protection against HIV infection. CD8 T cells at the site of infection