Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ryan S Soderquist"'
Autor:
Cody Paiva, J Claire Godbersen, Ryan S Soderquist, Taylor Rowland, Sumner Kilmarx, Stephen E Spurgeon, Jennifer R Brown, Sreesha P Srinivasa, Alexey V Danilov
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143685 (2015)
CDK (cyclin-dependent kinase) inhibitors have shown remarkable activity in CLL, where its efficacy has been linked to inhibition of the transcriptional CDKs (7 and 9) and deregulation of RNA polymerase and short-lived pro-survival proteins such as MC
Externí odkaz:
https://doaj.org/article/76cdc642921945679fd81474213b76e4
Autor:
Shane T. Killarney, Rachel Washart, Ryan S. Soderquist, Jacob P. Hoj, Jamie Lebhar, Kevin H. Lin, Kris C. Wood
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
During apoptosis, mitochondrial outer membrane permeabilization results in cytosolic mitochondrial RNA (mtRNA). Here, the authors demonstrate that caspase-3/7 inhibition promotes a cytosolic mtRNA-driven Type I interferon response via MDA5/MAVS/IRF3,
Externí odkaz:
https://doaj.org/article/94021e96acd04ecf873c4eec58ea4e06
Autor:
Ryan S. Soderquist, Lorin Crawford, Esther Liu, Min Lu, Anika Agarwal, Grace R. Anderson, Kevin H. Lin, Peter S. Winter, Merve Cakir, Kris C. Wood
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Dependency of diverse cancers on specific BCL-2 family members and their combinations is unknown. Here they perform drug screening and find most cell lines to be dependent on at least one combination of BCL-2 family members, and using a CRISPR screen
Externí odkaz:
https://doaj.org/article/d950f5d4286b4fd19e6d199b06c153c5
Autor:
Yolanda Sanchez, Nancy Ratner, William Seibel, Sandra Nelson, Ami V. Patel, Ryan S. Soderquist, Shu Pang, Gunnar Johansson, Melissa Rawe, Matthew Wood
Supplemental Materials and Methods Supplemental Figure 1 â€" Analysis of a UC1-like compound. Supplemental Figure 2 â€" Plasmid shuffle system for high-efficiency transformation of erg6Δira2 Δ yeast cells. Supplemental Figure 3 â€" Phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129632b380f8deb85829779961e60981
https://doi.org/10.1158/1535-7163.22496400
https://doi.org/10.1158/1535-7163.22496400
Autor:
Yolanda Sanchez, Nancy Ratner, William Seibel, Sandra Nelson, Ami V. Patel, Ryan S. Soderquist, Shu Pang, Gunnar Johansson, Melissa Rawe, Matthew Wood
Supplementary Methods, Figures 1-3 from Discovery of a Small Molecule Targeting IRA2 Deletion in Budding Yeast and Neurofibromin Loss in Malignant Peripheral Nerve Sheath Tumor Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0e144177d61454fea925630d0bca5b
https://doi.org/10.1158/1535-7163.22496397
https://doi.org/10.1158/1535-7163.22496397
Autor:
Yolanda Sanchez, Nancy Ratner, William Seibel, Sandra Nelson, Ami V. Patel, Ryan S. Soderquist, Shu Pang, Gunnar Johansson, Melissa Rawe, Matthew Wood
Malignant peripheral nerve sheath tumor (MPNST) is a life-threatening complication of neurofibromatosis type 1 (NF1). NF1 is caused by mutation in the gene encoding neurofibromin, a negative regulator of Ras signaling. There are no effective pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183a987630d061aeb45aaadcc29fca34
https://doi.org/10.1158/1535-7163.c.6535257
https://doi.org/10.1158/1535-7163.c.6535257
Autor:
Moiez Ali, Min Lu, Hazel Xiaohui Ang, Ryan S. Soderquist, Christine E. Eyler, Haley M. Hutchinson, Carolyn Glass, Christopher F. Bassil, Omar M. Lopez, D. Lucas Kerr, Christina J. Falcon, Helena A. Yu, Aaron N. Hata, Collin M. Blakely, Caroline E. McCoach, Trever G. Bivona, Kris C. Wood
Publikováno v:
Science translational medicine, vol 14, iss 638
Residual cancer cells that survive drug treatments with targeted therapies act as a reservoir from which eventual resistant disease emerges. Although there is great interest in therapeutically targeting residual cells, efforts are hampered by our lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87301bafcf92eb5ae24f348c85cd184
https://pubmed.ncbi.nlm.nih.gov/35353542
https://pubmed.ncbi.nlm.nih.gov/35353542
Publikováno v:
Cell Death and Disease, Vol 10, Iss 3, Pp 1-13 (2019)
Cell Death & Disease
Cell Death & Disease
Targeting anti-apoptotic BCL2 family proteins has become an attractive therapeutic strategy for many cancers, and the BCL2-selective inhibitor ABT-199 (venetoclax) has obtained clinical success. However, MCL1 can promote drug resistance and overall c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6cb6a575bb81c2d97cbc7d82ef5122
http://link.springer.com/article/10.1038/s41419-019-1426-3
http://link.springer.com/article/10.1038/s41419-019-1426-3
Autor:
Rachel N. Skelton, Merve Cakir, Simone A. Costa, Suzanne E. Wardell, Mitchell Zhang, Kevin H. Lin, Ashutosh Chilkoti, Kris C. Wood, Mareva Fevre, Joseph J. Bellucci, Ryan S. Soderquist, Mandana T. Manzari, Grace R. Anderson, Xinghai Li, Chandler E. Moore
Publikováno v:
Science Advances
Precision medicine strategy enables rational design of small molecule/protein drug combinations to overcome intrinsic resistance.
Extrinsic pathway agonists have failed repeatedly in the clinic for three core reasons: Inefficient ligand-induced
Extrinsic pathway agonists have failed repeatedly in the clinic for three core reasons: Inefficient ligand-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5782b47b23287b5a0d483017cb2a7ae
http://europepmc.org/articles/PMC6726446
http://europepmc.org/articles/PMC6726446
Autor:
Min Lu, Anika Agarwal, Peter S. Winter, Kevin H. Lin, Esther Liu, Kris C. Wood, Merve Cakir, Grace R. Anderson, Ryan S. Soderquist, Lorin Crawford
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
While inhibitors of BCL-2 family proteins (BH3 mimetics) have shown promise as anti-cancer agents, the various dependencies or co-dependencies of diverse cancers on BCL-2 genes remain poorly understood. Here we develop a drug screening approach to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac34d2c33add7211a5c3ede87b32dd9
https://doi.org/10.1038/s41467-018-05815-z
https://doi.org/10.1038/s41467-018-05815-z