Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ryan S MacLeod"'
Autor:
Ryan S MacLeod, Mark B Meyer, Jinhu Xiong, Keisha M Cawley, Yu Liu, Melda Onal, Nancy A Benkusky, Jeff D Thostenson, J Wesley Pike, Charles A O'Brien
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250974 (2021)
The cytokine RANKL is essential for osteoclast formation during physiological and pathological bone resorption. RANKL also contributes to lymphocyte production, development of lymph nodes and mammary glands, as well as other biological activities. Tr
Externí odkaz:
https://doaj.org/article/4047ea3d5756425eb485380cdefc3d75
Autor:
Nisreen, Akel, Ryan S, MacLeod, Stuart B, Berryhill, Dominique J, Laster, Milena, Dimori, Julie A, Crawford, Qiang, Fu, Melda, Onal
Publikováno v:
Scientific Reports. 12
Chaperone-mediated autophagy (CMA) is a protein degradation pathway that eliminates soluble cytoplasmic proteins that are damaged, incorrectly folded, or targeted for selective proteome remodeling. However, the role of CMA in skeletal homeostasis und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f126725f3d66d0be5fa8b76dfc122e6e
https://doi.org/10.1038/s41598-022-07157-9
https://doi.org/10.1038/s41598-022-07157-9
Autor:
Yonghan He, Yuko Fujiwara, Li Han, Keisha M. Cawley, Daohong Zhou, Jinhu Xiong, Ha-Neui Kim, Ryan S. MacLeod, Charles A. O'Brien, Maria Almeida, Elisabeth Ferreira, Robert L. Jilka, Srividhya Iyer, Jeff D. Thostenson
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 19 (2020)
JCI Insight, Vol 5, Iss 19 (2020)
In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine RANKL, encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f452dd6484bf78fd568027e9a0c82ab3
https://doi.org/10.1172/jci.insight.138815
https://doi.org/10.1172/jci.insight.138815
Autor:
Jinhu Xiong, Jeff D. Thostenson, Anveshi G. Guha, Michela Palmieri, Robin Mulkey, Charles A. O'Brien, Nancy Cecile Bustamante-Gomez, Joseph J. Goellner, Ryan S. MacLeod, Yu Liu, Keisha M. Cawley, Igor Gubrij
Publikováno v:
SSRN Electronic Journal.
Osteoprotegerin (OPG) inhibits the ability of receptor activator of NFkB ligand (RANKL) to stimulate the differentiation, activity, and survival of bone resorbing osteoclasts. Genetic studies in mice show that osteocytes are an important source of RA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::117788b9950877bed1ccb185bccb0eeb
https://doi.org/10.2139/ssrn.3565032
https://doi.org/10.2139/ssrn.3565032
Autor:
Ryan S. MacLeod, Melda Onal, Igor Gubrij, Charles A. O'Brien, Intawat Nookaew, Keisha M. Cawley
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Drawbacks of conditional gene deletion in mice include the need for extensive breeding and, often, a lack of cell type-specificity. CRISPR interference (CRISPRi) is an alternative approach for loss-of-function studies that inhibits expression by guid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cada99369618ace0d112ca2440db5fbf
https://doi.org/10.1038/s41598-019-53611-6
https://doi.org/10.1038/s41598-019-53611-6
Autor:
Charles A. O'Brien, Yu Liu, Jeff D. Thostenson, Ryan S. MacLeod, Jinhu Xiong, Mark B. Meyer, Melda Onal, J. Wesley Pike, Keisha M. Cawley, Nancy A. Benkusky
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250974 (2021)
PLoS ONE
PLoS ONE
The cytokine RANKL is essential for osteoclast formation during physiological and pathological bone resorption. RANKL also contributes to lymphocyte production, development of lymph nodes and mammary glands, as well as other biological activities. Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b56be99fa7a8da428b990efc9e829d
https://doi.org/10.1371/journal.pone.0250974
https://doi.org/10.1371/journal.pone.0250974
Autor:
Ha-Neui Kim, Jinhu Xiong, Ryan S. MacLeod, Srividhya Iyer, Yuko Fujiwara, Keisha M. Cawley, Li Han, Yonghan He, Jeff D. Thostenson, Elisabeth Ferreira, Robert L. Jilka, Daohong Zhou, Maria Almeida, Charles A. O’Brien
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine RANKL, encod
Externí odkaz:
https://doaj.org/article/657c52f5dd0742dba28700a3da2de806