Výsledky vyhledávání - "Ryan S Cross"

Akademický článek

Human EGFRvIII chimeric antigen receptor T cells demonstrate favorable safety profile and curative responses in orthotopic glioblastoma

Autor: Rebecca C Abbott, Melinda Iliopoulos, Katherine A Watson, Valeria Arcucci, Margareta Go, Hannah E Hughes‐Parry, Pete Smith, Melissa J Call, Ryan S Cross, Misty R Jenkins

Publikováno v: Clinical & Translational Immunology, Vol 12, Iss 3, Pp n/a-n/a (2023)

Abstract Objectives Glioblastoma is a highly aggressive and fatal brain malignancy, and effective targeted therapies are required. The combination of standard treatments including surgery, chemotherapy and radiotherapy is not curative. Chimeric antig

Externí odkaz: https://doaj.org/article/daa67b3f5e504aa1970ae6379d7e3fcb

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Akademický článek

De novo-designed transmembrane domains tune engineered receptor functions

Autor: Assaf Elazar, Nicholas J Chandler, Ashleigh S Davey, Jonathan Y Weinstein, Julie V Nguyen, Raphael Trenker, Ryan S Cross, Misty R Jenkins, Melissa J Call, Matthew E Call, Sarel J Fleishman

Publikováno v: eLife, Vol 11 (2022)

De novo-designed receptor transmembrane domains (TMDs) present opportunities for precise control of cellular receptor functions. We developed a de novo design strategy for generating programmed membrane proteins (proMPs): single-pass α-helical TMDs

Externí odkaz: https://doaj.org/article/4c88ae4a5ecb43b5a0ea6b73ec898c18

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Akademický článek

Novel high‐affinity EGFRvIII‐specific chimeric antigen receptor T cells effectively eliminate human glioblastoma

Autor: Rebecca C Abbott, Daniel J Verdon, Fiona M Gracey, Hannah E Hughes‐Parry, Melinda Iliopoulos, Katherine A Watson, Matthias Mulazzani, Kylie Luong, Colleen D’Arcy, Lucy C Sullivan, Ben R Kiefel, Ryan S Cross, Misty R Jenkins

Publikováno v: Clinical & Translational Immunology, Vol 10, Iss 5, Pp n/a-n/a (2021)

Abstract Objectives The increasing success of Chimeric Antigen Receptor (CAR) T cell therapy in haematological malignancies is reinvigorating its application in many other cancer types and with renewed focus on its application to solid tumors. We pre

Externí odkaz: https://doaj.org/article/bf76bd27261b474fb7938f17c07c871c

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Akademický článek

Hsp70 architecture: the formation of novel polymeric structures of Hsp70.1 and Hsc70 after proteotoxic stress.

Autor: Rohan Steel, Ryan S Cross, Sarah L Ellis, Robin L Anderson

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52351 (2012)

Heat induces Hsp70.1 (HSPA1) and Hsc70 (HSPA8) to form complex detergent insoluble cytoplasmic and nuclear structures that are distinct from the cytoskeleton and internal cell membranes. These novel structures have not been observed by earlier immuno

Externí odkaz: https://doaj.org/article/fab2197f28084ae199163cf76363557e

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