Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ryan S, Phillips"'
Publikováno v:
eLife, Vol 11 (2022)
Previously our computational modeling studies (Phillips et al., 2019) proposed that neuronal persistent sodium current (INaP) and calcium-activated non-selective cation current (ICAN) are key biophysical factors that, respectively, generate inspirato
Externí odkaz:
https://doaj.org/article/dd1515b461b44c10a4cf3a5fd3aeda58
Autor:
Ryan S Phillips, Jonathan E Rubin
Publikováno v:
eLife, Vol 11 (2022)
Inspiratory breathing rhythms arise from synchronized neuronal activity in a bilaterally distributed brainstem structure known as the preBötzinger complex (preBötC). In in vitro slice preparations containing the preBötC, extracellular potassium mu
Externí odkaz:
https://doaj.org/article/3771e810f2c54d19aa3815da29798da3
Publikováno v:
eLife, Vol 9 (2020)
As a rodent basal ganglia (BG) output nucleus, the substantia nigra pars reticulata (SNr) is well positioned to impact behavior. SNr neurons receive GABAergic inputs from the striatum (direct pathway) and globus pallidus (GPe, indirect pathway). Domi
Externí odkaz:
https://doaj.org/article/010eb32a3e8440aea99a723690af2ab5
Autor:
Nicholas J. Burgraff, Ryan S. Phillips, Liza J. Severs, Nicholas E. Bush, Nathan A. Baertsch, Jan-Marino Ramirez
Publikováno v:
J Neurophysiol
Cellular and network properties must be capable of generating rhythmic activity that is both flexible and stable. This is particularly important for breathing, a rhythmic behavior that dynamically adapts to environmental, behavioral, and metabolic ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae08a6f6843cd76b4b7655c25d1ce7e
https://doi.org/10.1152/jn.00150.2022
https://doi.org/10.1152/jn.00150.2022
Autor:
Ryan S Phillips, Jonathan E Rubin
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 8, p e1006938 (2019)
The mechanism(s) of action of most commonly used pharmacological blockers of voltage-gated ion channels are well understood; however, this knowledge is rarely considered when interpreting experimental data. Effects of blockade are often assumed to be
Externí odkaz:
https://doaj.org/article/e471841090744329a7dc5fa7d43b096b
Publikováno v:
eLife, Vol 8 (2019)
An autorhythmic population of excitatory neurons in the brainstem pre-Bötzinger complex is a critical component of the mammalian respiratory oscillator. Two intrinsic neuronal biophysical mechanisms—a persistent sodium current ([Formula: see text]
Externí odkaz:
https://doaj.org/article/0f6806d48aff400796045da8626a121b
Autor:
Jonathan E. Rubin, Ryan S Phillips
Inspiratory breathing rhythms arise from synchronized neuronal activity in a bilaterally distributed brainstem structure known as the preBötzinger complex (preBötC). In in vitro slice preparations containing the preBötC, extracellular potassium mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0bb864727c6904bc0de1389035248ef
https://doi.org/10.1101/2021.11.19.469304
https://doi.org/10.1101/2021.11.19.469304
Publikováno v:
Journal of computational neuroscience. 50(2)
Intensive computational and theoretical work has led to the development of multiple mathematical models for bursting in respiratory neurons in the pre-Bötzinger Complex (pre-BötC) of the mammalian brainstem. Nonetheless, these previous models have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40702aaa06ca01e86deb828bc0c40148
https://pubmed.ncbi.nlm.nih.gov/34704174
https://pubmed.ncbi.nlm.nih.gov/34704174