Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Ryan S, Funk"'
Autor:
Amar Kumar, Joshua Tatarian, Valentina Shakhnovich, Rachel L. Chevalier, Marc Sudman, Daniel J. Lovell, Susan D. Thompson, Mara L. Becker, Ryan S. Funk
Publikováno v:
Metabolites, Vol 14, Iss 9, p 499 (2024)
Identification of disease and therapeutic biomarkers remains a significant challenge in the early diagnosis and effective treatment of juvenile idiopathic arthritis (JIA). In this study, plasma metabolomic profiling was conducted to identify disease-
Externí odkaz:
https://doaj.org/article/1f581cc179f34567aea7349b03be520c
Autor:
Ryan S. Funk, Valentina Shakhnovich, Yu Kyoung Cho, Kishore Polireddy, Taina Jausurawong, Kyle Gress, Mara L. Becker
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-11 (2021)
Abstract Background Inadequate systemic exposure to infliximab (IFX) is associated with treatment failure. This work evaluated factors associated with reduced IFX exposure in children with autoimmune disorders requiring IFX therapy. Methods In this s
Externí odkaz:
https://doaj.org/article/06e56cc9e51a4d5c9b232b0eafa4a821
Autor:
Akinyemi Oni‐Orisan, Nithya Srinivas, Krina Mehta, Jesmin Lohy Das, Thu T. Nguyen, Geoffrey H. Tison, Scott R. Bauer, Maria Burian, Ryan S. Funk, Richard A. Graham, Biomarkers and Translational Tools Community Working Group of the American Society for Clinical Pharmacology and Therapeutics
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 784-790 (2021)
Abstract Although traditional approaches to biomarker discovery have elucidated key molecular markers that have improved drug selection (precision medicine), the discovery of biomarkers that inform optimal dose selection (precision dosing) continues
Externí odkaz:
https://doaj.org/article/a38a3cf9a98f4d94ab512a4c680c3614
Autor:
Valentina Shakhnovich, Bernd Meibohm, Amy Rosenberg, Andrzej M. Kierzek, Rachel Hasenkamp, Ryan S. Funk, Craig J. Thalhauser, Piet H. van derGraaf, Yow‐Ming C. Wang, Lora Hamuro
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 219-223 (2020)
Externí odkaz:
https://doaj.org/article/7e393e533b14403299f2fb8e170aff30
Metabolomic Profiling to Identify Molecular Biomarkers of Cellular Response to Methotrexate In Vitro
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 1, Pp 137-146 (2020)
Variation in methotrexate (MTX) efficacy represents a significant barrier to early and effective disease control in the treatment of autoimmune arthritis. We hypothesize that the utilization of metabolomic techniques will allow for an improved unders
Externí odkaz:
https://doaj.org/article/2ea512874976486fa1365f9063e9ce88
Autor:
Kyle Gress, Julie A. Bass, Ryan S. Funk, Ryan P. Morrow, Rachel Hasenkamp, Valentina Shakhnovich
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/15d8797b8f5d4bc5ba8c00727792de19
Publikováno v:
Metabolites, Vol 12, Iss 1, p 24 (2021)
Methotrexate (MTX) is widely used in the treatment of autoimmune arthritis but is limited by its unpredictable and variable response profile. Currently, no biomarkers exist to predict or monitor early therapeutic responses to MTX. Using a collagen-in
Externí odkaz:
https://doaj.org/article/ddc0a2caa5054cf7ae67f9f52aa01b96
Autor:
Matthew R. Medcalf, Pooja Bhadbhade, Ted R. Mikuls, James R. O’Dell, Rebekah L. Gundry, Ryan S. Funk
Publikováno v:
Metabolites, Vol 11, Iss 12, p 824 (2021)
Methotrexate (MTX) efficacy in the treatment of rheumatoid arthritis (RA) is variable and unpredictable, resulting in a need to identify biomarkers to guide drug therapy. This study evaluates changes in the plasma metabolome associated with response
Externí odkaz:
https://doaj.org/article/a65b59be9dd14d04a4415b95ee3d7621
Autor:
Tiffany R, Shin, Crystal, Burkhardt, Robyn, Kelton, Ashley N, Crowl, Ryan S, Funk, Sarah, Shrader
Publikováno v:
Currents in Pharmacy Teaching and Learning. 14:840-846
The purpose of this study was to determine the impact of a flipped classroom method based on cognitive science of learning strategies on student performance and experience in a third-year pharmacotherapy course.The cognitive science of learning flipp
Publikováno v:
J Pediatr Pharmacol Ther
OBJECTIVE To evaluate the impact of obesity on etanercept (ETN) drug exposure in children with juvenile idiopathic arthritis (JIA). METHODS We conducted a pilot, cross-sectional, observational study in a real-world cohort of children with JIA receivi