Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ryan Rodriguez del Villar"'
Autor:
Raffaella Soldi, Tithi Ghosh Halder, Alexis Weston, Trason Thode, Kevin Drenner, Rhonda Lewis, Mohan R Kaadige, Shreyesi Srivastava, Sherin Daniel Ampanattu, Ryan Rodriguez Del Villar, Jessica Lang, Hariprasad Vankayalapati, Bernard Weissman, Jeffrey M Trent, William P D Hendricks, Sunil Sharma
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235705 (2020)
Mutations of the SWI/SNF chromatin remodeling complex occur in 20% of all human cancers, including ovarian cancer. Approximately half of ovarian clear cell carcinomas (OCCC) carry mutations in the SWI/SNF subunit ARID1A, while small cell carcinoma of
Externí odkaz:
https://doaj.org/article/1c9aae36c158461f9a747a08ebf0de0f
Autor:
Tithi Ghosh Halder, Shelby Rheinschmidt, Sydney Adamson, Anna Larson, Taylor Bargenquast, Ryan Rodriguez del Villar, Serina Ng, Kate Gutowsky, Alexis Weston, Trason Thode, Mohan Kaadige, Erin Kelley, Jorge Soria-Bustos, Jorge Giron, John Altin, Raffaella Soldi, Sunil Sharma
Publikováno v:
Cancer Research. 83:4060-4060
Background: Immunotherapies using autologous tumor infiltrating lymphocytes (TILs) have become effective treatment modalities for several patients with solid tumors, yielding a response rate of around 49% in patients with metastatic melanoma. Most cl
Autor:
Stephen K. Horrigan, Trason Thode, Serina Ng, Sunil Sharma, Ravi Salgia, Hariprasad Vankayalapati, Kevin Drenner, Raffaella Soldi, Mohan R. Kaadige, Samuel Sampson, Ryan Rodriguez del Villar, Surinder K. Batra, Alexis Weston, Tithi Ghosh Halder, Kapil N. Bhalla
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 378:77-86
The central role of β-catenin in the Wnt pathway makes it an attractive therapeutic target for cancers driven by aberrant Wnt signaling. We recently developed a small-molecule inhibitor, BC-2059, that promotes apoptosis by disrupting the β-catenin/
Autor:
Alexis Weston, Trason Thode, Ryan Rodriguez del Villar, Serina Ng, Samuel Sampson, Shelby Rheinschmidt, Tithi Ghosh Halder, Raffaella Soldi, Mohan Kaadige, Srinivas Kasibhatla, Haiyong Han, Justin Moser, Vincent Chung, Joseph Chao, Victoria Villaflor, Daniel Von Hoff, Sunil Sharma
Publikováno v:
Cancer Research. 82:3931-3931
Purpose: Overexpression of Cyclin-Dependent Kinase 7 (CDK7) is linked to poor clinical outcomes in a variety of cancer types including AML, breast, ovarian, pancreatic, and lung cancers. CDK7 plays a dual role in tumor progression by regulating the c
Autor:
Shelby Rheinschmidt, Trason Thode, Samuel Sampson, Alexis Weston, Tithi Ghosh Halder, Serina Ng, Ryan Rodriguez del Villar, Mohan Kaadige, Anton Zernov, Marcelle Machluf, Raffaella Soldi, Sunil Sharma
Publikováno v:
Cancer Research. 82:2567-2567
Purpose: Canonical Wnt signaling is a key cascade in regulating development and stemness, however it can become dysregulated and tightly associated with oncogenesis. In human cancers, Wnt/β-catenin signaling is highly activated due to mutations of m
Autor:
Trason Thode, Jaime Fornetti, Ryan Rodriguez del Villar, Alexis Weston, Serina Ng, Srikanta Dana, Raffaella Soldi, Mohan Kaadige, Hariprasad Vankayalapati, Srinivas Kasibhatla, Alana Welm, Sunil Sharma
Publikováno v:
Cancer Research. 82:3948-3948
Purpose: About 500,000 people each year worldwide die from metastatic breast cancer. More than 70% of these metastatic breast cancer patients have bone metastases and median survival time from diagnosis of bone metastasis is only 2-3 years. As breast
Autor:
Samuel Sampson, Trason Thode, Kevin Drenner, Ryan Rodriguez Del Villar, Annika Ozols, Mohan Kaadige, Alexis Weston, Serina Ng, Tithi Ghosh Halder, Shelby Rheinschmidt, David Anderson, Kevin Holden, Raffaella Soldi, Sunil Sharma
Publikováno v:
Cancer Research. 82:1048-1048
Background: Ewing's Sarcoma (ES) is a rare and aggressive pediatric bone tumor that is driven by a chromosomal translocation and fusion between EWS and FLI1 genes resulting in a chimeric protein. Nearly 85% of ES cases express the EWS/FLI protein whi
Autor:
Tithi Ghosh Halder, Shelby Rheinschmidt, Trason Thode, Samuel Sampson, Ryan Rodriguez del Villar, Serina Ng, Alexis Weston, Mohan Kaadige, Jeffery Trent, John Altin, Justin Moser, Erkut Borazanci, Michael Gordon, Anna Larson, Raffaella Soldi, Sunil Sharma
Publikováno v:
Cancer Research. 82:1878-1878
The interaction between tumor cells and immune system has been studied mostly in animal models and co-cultures with cell lines. However, it is difficult to study the unique features of human immune cells in mice, and cell lines are often transformed
Autor:
Raffaella, Soldi, Tithi Ghosh, Halder, Samuel, Sampson, Hariprasad, Vankayalapati, Alexis, Weston, Trason, Thode, Kapil N, Bhalla, Serina, Ng, Ryan, Rodriguez Del Villar, Kevin, Drenner, Mohan R, Kaadige, Stephen K, Horrigan, Surinder K, Batra, Ravi, Salgia, Sunil, Sharma
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 378(2)
The central role of
Autor:
Lawrence Matiski, Xiaowei Liu, Shuoxing Jiang, Theresa Yip, Li Liu, Fei Zhang, Hao Yan, Ryan Rodriguez Del Villar, Xiaodong Qi, Sriram Sokalingam, Yung Chang
Publikováno v:
ACS nano. 14(4)
Rapid developments in nucleic acid nanotechnology have enabled the rational design and construction of self-assembling DNA and RNA nanostructures that are highly programmable. We recently developed a replicable single-stranded RNA origami (RNA-OG) te