Late radiation-related lymphopenia after prostate stereotactic body radiation therapy plus or minus supplemental pelvic irradiation

Autor: Kelly Gaudian, Min Jung Koh, Min Ji Koh, Peter Jermain, Irfan Khan, Diya Kallam, Zach Lee, Ryan R. Collins, Zoya Zwart, Malika Danner, Alan Zwart, Deepak Kumar, Michael B. Atkins, Simeng Suy, Sean P. Collins

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

IntroductionPrior studies suggest lymphopenia following radiation therapy may impact toxicity and cancer control. Chronic radiation-related lymphopenia (RRL) has been noted in prostate cancer patients treated with conventionally fractionated pelvic r

Externí odkaz: https://doaj.org/article/a84efa618455491090554a44fc51390f

Integrative Analysis of Germline Rare Variants in Clear and Non-clear Cell Renal Cell Carcinoma.

Autor: Han SH; Ph.D. Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Camp SY; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chu H; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Collins R; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Gillani R; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Boston Children's Hospital, Boston, MA, USA., Park J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bakouny Z; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ricker CA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Reardon B; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Moore N; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA., Kofman E; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Labaki C; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Braun D; Center of Molecular and Cellular Oncology, Yale School of Medicine, New Haven, CT, USA., Choueiri TK; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA., AlDubayan SH; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia., Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA.

Publikováno v: European urology open science [Eur Urol Open Sci] 2024 Mar 08; Vol. 62, pp. 107-122. Date of Electronic Publication: 2024 Mar 08 (Print Publication: 2024).

Integrative Analysis of Germline Rare Variants in Clear and Non-Clear Cell Renal Cell Carcinoma.

Autor: Han S; Ph.D. Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Camp SY; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chu H; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Collins R; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Gillani R; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Boston Children's Hospital, Boston, MA, USA., Park J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bakouny Z; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ricker CA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Reardon B; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Moore N; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA., Kofman E; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Labaki C; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Braun D; Center of Molecular and Cellular Oncology, Yale School of Medicine, New Haven, CT, USA., Choueiri TK; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA., AlDubayan SH; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia., Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Jan 19. Date of Electronic Publication: 2023 Jan 19.

Correlation of tumor microenvironment from biopsy and resection specimens in untreated colorectal cancer patients: a surprising lack of agreement.

Autor: Kemp Bohan PM; Department of Surgery, Brooke Army Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, TX, 78234, USA. phillip.m.kempbohan.mil@mail.mil., Chick RC; Department of Surgery, Brooke Army Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, TX, 78234, USA., Hickerson AT; Department of Surgery, Brooke Army Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, TX, 78234, USA., Messersmith LM; Department of Pathology, Brooke Army Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, TX, 78234, USA., Williams GM; Department of Pathology, Brooke Army Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, TX, 78234, USA., Cindass JL; Department of Surgery, Brooke Army Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, TX, 78234, USA., Lombardo J; Department of Pathology, Brooke Army Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, TX, 78234, USA., Collins R; Department of Pathology, Brooke Army Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, TX, 78234, USA., Brady RO; Department of Pathology, Brooke Army Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, TX, 78234, USA., Hale DF; Department of Surgery, Brooke Army Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, TX, 78234, USA., Peoples GE; Cancer Vaccine Development Program, 1422 E. Grayson St, San Antonio, TX, 78208, USA., Vreeland TJ; Department of Surgery, Brooke Army Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, TX, 78234, USA., Clifton GT; Department of Surgery, Brooke Army Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, TX, 78234, USA.

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 May; Vol. 70 (5), pp. 1465-1474. Date of Electronic Publication: 2020 Nov 12.

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism.

Autor: Satterstrom FK; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kosmicki JA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Wang J; Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA., Breen MS; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., De Rubeis S; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., An JY; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, Republic of Korea., Peng M; Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA., Collins R; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA., Grove J; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark; Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark., Klei L; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Stevens C; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Reichert J; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mulhern MS; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Artomov M; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Gerges S; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Sheppard B; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Xu X; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bhaduri A; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA., Norman U; Computer Engineering Department, Bilkent University, Ankara, Turkey., Brand H; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Schwartz G; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Nguyen R; Center for Autism Research and Translation, University of California, Irvine, Irvine, CA, USA., Guerrero EE; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA, USA., Dias C; Division of Genetics, Boston Children's Hospital, Boston, MA, USA; Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA., Betancur C; Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine, Institut de Biologie Paris Seine, Paris, France., Cook EH; Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA., Gallagher L; Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland., Gill M; Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland., Sutcliffe JS; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Molecular Physiology and Biophysics and Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA., Thurm A; National Institute of Mental Health, NIH, Bethesda, MD, USA., Zwick ME; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Børglum AD; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark; Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark., State MW; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Cicek AE; Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA; Computer Engineering Department, Bilkent University, Ankara, Turkey., Talkowski ME; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Cutler DJ; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Devlin B; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sanders SJ; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: stephan.sanders@ucsf.edu., Roeder K; Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA. Electronic address: roeder@andrew.cmu.edu., Daly MJ; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. Electronic address: mjdaly@broadinstitute.org., Buxbaum JD; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: joseph.buxbaum@mssm.edu.

Publikováno v: Cell [Cell] 2020 Feb 06; Vol. 180 (3), pp. 568-584.e23. Date of Electronic Publication: 2020 Jan 23.