Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Ryan R. Clark"'
Autor:
Daniel A. Russell, J. A. Judd, Alexander Dills, Joseph T. Wade, Jemila C. Kester, M. Mir, Erica Lasek-Nesselquist, E. Dove, Sarah M. Fortune, Rebekah M. Dedrick, Pascal Lapierre, Christopher G Meier, Keith M. Derbyshire, Ian D. Wolf, A. Joseph, Ryan R Clark, M. Stone, Graham F. Hatfull, Jill G. Canestrari, Junhao Zhu, Todd A. Gray, Samantha E. Wirth, Ashutosh Upadhyay, E. R. Rubin, Michael J. Palumbo, Carol Smith
Publikováno v:
mBio
mBio, Vol 12, Iss 2 (2021)
mBio, Vol 12, Iss 2 (2021)
Diseases caused by mycobacterial species result in millions of deaths per year globally, and present a substantial health and economic burden, especially in immunocompromised patients. Difficulties inherent in working with mycobacterial pathogens hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26779fa33222648452693fc48bf4c821
http://europepmc.org/articles/PMC8092266
http://europepmc.org/articles/PMC8092266
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2075
Horizontal gene transfer (HGT) in prokaryotes disseminates genetic information throughout a population and can facilitate adaptation and evolution of the species. Mycobacteria utilize an atypical method of conjugation called distributive conjugal tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f62423c833c07beba6ce6609d198ee3e
https://pubmed.ncbi.nlm.nih.gov/31584159
https://pubmed.ncbi.nlm.nih.gov/31584159
Publikováno v:
Horizontal Gene Transfer ISBN: 9781493998760
Horizontal gene transfer (HGT) in prokaryotes disseminates genetic information throughout a population and can facilitate adaptation and evolution of the species. Mycobacteria utilize an atypical method of conjugation called distributive conjugal tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da1a9b54540656c0363f429e79b9a5e5
https://doi.org/10.1007/978-1-4939-9877-7_9
https://doi.org/10.1007/978-1-4939-9877-7_9
Autor:
Pascal Lapierre, Todd A. Gray, Keith M. Derbyshire, Nathalie Boucher, Carol Smith, Ryan R Clark
Publikováno v:
Science
Mycobacteria encompass several slow-growing pathogens, including organisms that cause leprosy and tuberculosis. Mycobacteria use a component of their ESX (or Type VII) secretion system for a distinctive form of genetic exchange called distributive co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84facbd23224f4ff47487d232789666e
https://doi.org/10.1126/science.aag0828
https://doi.org/10.1126/science.aag0828
Autor:
Ryan R. Clark, María del Pilar Sosa Idelchik, Ahmad A Nazem, Nicole L Shakerley, Donald A McCarthy, James McNeilan, Mehmet V. Yigit, J. Andres Melendez
Publikováno v:
Experimental Biology and Medicine. 241:2023-2032
The wide array of proteases, including matrix metalloproteinases, produced in response to many pathogenic insults, confers a unique proteolytic signature which is often disease specific and provides a potential therapeutic target for drug delivery. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8b5d578fcc2ab30a571f42f4ecd17c
https://doi.org/10.1177/1535370216662534
https://doi.org/10.1177/1535370216662534
Autor:
Keith M. Derbyshire, Jennifer G Hoffmann, Ryan R Clark, Erica Lasek-Nesselquist, Julius Judd, Sarah A Montgomery, Todd A. Gray
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Conjugal cell-cell contact between strains of Mycobacterium smegmatis induces the esxUT transcript, which encodes the putative primary substrates of the ESAT-6 secretion system 4 (ESX-4) secretion system. This recipient response was required for conj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39091f301f311da4dee8f90688a8947b
https://doi.org/10.1073/pnas.1804227115
https://doi.org/10.1073/pnas.1804227115
Autor:
Nate J. Doty, Ryan R. Clark, William L. Murphy, Sarah K. Atzet, Michael P. Schwartz, Michael W. Toepke, Thomas I. Zarembinski, William F. Hynes, J. Andres Melendez, Nathaniel C. Cady
Publikováno v:
Biosensors; Volume 4; Issue 1; Pages: 28-44
Biosensors
Biosensors, Vol 4, Iss 1, Pp 28-44 (2014)
Biosensors
Biosensors, Vol 4, Iss 1, Pp 28-44 (2014)
Micro-scale printing and patterning of living cells has multiple applications including tissue engineering, cell signaling assays, and the fabrication of cell-based biosensors. In this work, a molecular printing instrument, the Bioforce Nano eNabler,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afd91fd18e6ee8a04ddcd3c18c4c3bd
Publikováno v:
The Journal of biological chemistry. 288(45)
Senescent cells accumulate in aged tissue and are causally linked to age-associated tissue degeneration. These non-dividing, metabolically active cells are highly secretory and alter tissue homeostasis, creating an environment conducive to metastatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34f016fa6939f49ec450a41bc81efe4
https://pubmed.ncbi.nlm.nih.gov/24062309
https://pubmed.ncbi.nlm.nih.gov/24062309
Autor:
Ryan R. Clark, Akshaya Chandrasekaran, Toni R. Bartling, J. Andres Melendez, Sita Subbaram, Supriya Kar
Publikováno v:
Free radical biologymedicine. 74
Aberrant matrix metalloproteinase-1 (MMP-1) expression contributes to the pathogenesis of many degenerative disease processes that are associated with increased oxidative damage or stress. We and others have established that shifts in steady-state H2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b7d79d6f3aefd36736c92ef6ba40a2
https://pubmed.ncbi.nlm.nih.gov/24973648
https://pubmed.ncbi.nlm.nih.gov/24973648
Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage
Autor:
Thomas J. Begley, J. Andres Melendez, Chen Gu, Ulrike Begley, Lauren Endres, Agnieszka Dziergowska, Andrzej Malkiewicz, Ryan R. Clark, Peter C. Dedon
Publikováno v:
Public Library of Science
PLoS ONE, Vol 10, Iss 7, p e0131335 (2015)
PLoS ONE
PLoS ONE, Vol 10, Iss 7, p e0131335 (2015)
PLoS ONE
Environmental and metabolic sources of reactive oxygen species (ROS) can damage DNA, proteins and lipids to promote disease. Regulation of gene expression can prevent this damage and can include increased transcription, translation and post translati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abca79a50e20ec4eb6ae7f4049634c76
https://doi.org/10.1371/journal.pone.0131335
https://doi.org/10.1371/journal.pone.0131335