Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy

Autor: Jose H. Pereira, Ryan P. McAndrew, Oksana A. Sergeeva, Corie Y. Ralston, Jonathan A. King, Paul D. Adams

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract The human chaperonin TRiC consists of eight non-identical subunits, and its protein-folding activity is critical for cellular health. Misfolded proteins are associated with many human diseases, such as amyloid diseases, cancer, and neuropath

Externí odkaz: https://doaj.org/article/380cea13dfbc4d1c99c09ee67ecb6f29

Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases

Autor: Tyler W. H. Backman, Hector Garcia Martin, Jay D. Keasling, Edward E. K. Baidoo, Jose Henrique Pereira, Veronica T. Benites, Jesus F. Barajas, Ryan P. McAndrew, Paul D. Adams, Mitchell G. Thompson, Nathan J. Hillson, Bo Pang, Tristan de Rond

Publikováno v: Barajas, Jesus F; McAndrew, Ryan P; Thompson, Mitchell G; Backman, Tyler WH; Pang, Bo; de Rond, Tristan; et al.(2019). Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases.. Journal of industrial microbiology & biotechnology. doi: 10.1007/s10295-019-02189-z. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/9338h07m
Journal of industrial microbiology & biotechnology, vol 46, iss 8
Barajas, J F, McAndrew, R P, Thompson, M G, Backman, T W H, Pang, B, de Rond, T, Pereira, J H, Benites, V T, Martín, H G, Baidoo, E E K, Hillson, N J, Adams, P D & Keasling, J D 2019, ' Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases ', Journal of Industrial Microbiology and Biotechnology, vol. 46, no. 8, pp. 1225-1235 . https://doi.org/10.1007/s10295-019-02189-z
Journal of Industrial Microbiology & Biotechnology

Engineered polyketide synthases (PKSs) are promising synthetic biology platforms for the production of chemicals with diverse applications. The dehydratase (DH) domain within modular type I PKSs generates an α,β-unsaturated bond in nascent polyketi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94ce53f7684bc8a9808952804916fab
http://www.escholarship.org/uc/item/9338h07m

Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy

Autor: Corie Y. Ralston, Jose Henrique Pereira, Ryan P. McAndrew, Jonathan King, Oksana A. Sergeeva, Paul D. Adams

Publikováno v: Scientific Reports
Scientific reports, vol 7, iss 1
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Pereira, JH; McAndrew, RP; Sergeeva, OA; Ralston, CY; King, JA; & Adams, PD. (2017). Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy. Scientific Reports, 7(1). doi: 10.1038/s41598-017-03825-3. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/86m174ss

The human chaperonin TRiC consists of eight non-identical subunits, and its protein-folding activity is critical for cellular health. Misfolded proteins are associated with many human diseases, such as amyloid diseases, cancer, and neuropathies, maki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef5dde54b113905da8ccf3791dcd88b
http://europepmc.org/articles/PMC5473854

From Soil to Structure, a Novel Dimeric β-Glucosidase Belonging to Glycoside Hydrolase Family 3 Isolated from Compost Using Metagenomic Analysis

Autor: Patrik D'haeseleer, Ryan P. McAndrew, Kenneth L. Sale, Richard A. Heins, Paul D. Adams, Joshua I. Park, Trent R. Northen, Wolfgang Reindl, Gregory D. Friedland, Blake A. Simmons

Publikováno v: Journal of Biological Chemistry. 288:14985-14992

A recent metagenomic analysis sequenced a switchgrass-adapted compost community to identify enzymes from microorganisms that were specifically adapted to switchgrass under thermophilic conditions. These enzymes are being examined as part of the pretr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f30ef2188949a8eaf07d7f99ca6e422
https://doi.org/10.1074/jbc.m113.458356

Structure of a Three-Domain Sesquiterpene Synthase: A Prospective Target for Advanced Biofuels Production

Autor: Andy DeGiovanni, Pamela Peralta-Yahya, Paul D. Adams, Ryan P. McAndrew, Masood Z. Hadi, Jose Henrique Pereira, Jay D. Keasling

Publikováno v: Structure. 19(12):1876-1884

SummaryThe sesquiterpene bisabolene was recently identified as a biosynthetic precursor to bisabolane, an advanced biofuel with physicochemical properties similar to those of D2 diesel. High-titer microbial bisabolene production was achieved using Ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4f90f529bfa7295f5029d6a84f5a5d