Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Ryan P. Barnes"'
Autor:
Sanjana A. Thosar, Ryan P. Barnes, Ariana Detwiler, Ragini Bhargava, Anne Wondisford, Roderick J. O’Sullivan, Patricia L. Opresko
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113656- (2024)
Summary: Cancer cells maintain telomeres by upregulating telomerase or alternative lengthening of telomeres (ALT) via homology-directed repair at telomeric DNA breaks. 8-Oxoguanine (8oxoG) is a highly prevalent endogenous DNA lesion in telomeric sequ
Externí odkaz:
https://doaj.org/article/f73851718be544c6b21a5ffb5d002d87
Autor:
Namrata Kumar, Arjan F. Theil, Vera Roginskaya, Yasmin Ali, Michael Calderon, Simon C. Watkins, Ryan P. Barnes, Patricia L. Opresko, Alex Pines, Hannes Lans, Wim Vermeulen, Bennett Van Houten
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.
Externí odkaz:
https://doaj.org/article/677d2112db5041e7bd30b5fcd641a24a
Publikováno v:
Genes, Vol 14, Iss 2, p 348 (2023)
Telomeres present inherent difficulties to the DNA replication machinery due to their repetitive sequence content, formation of non-B DNA secondary structures, and the presence of the nucleo-protein t-loop. Especially in cancer cells, telomeres are h
Externí odkaz:
https://doaj.org/article/f880de9e6ff945c1b9d5634da444c674
Publikováno v:
BMC Pregnancy and Childbirth, Vol 22, Iss 1, Pp 1-7 (2022)
Abstract Background Optic nerve sheath diameters (ONSD) have been validated as an accurate screening tool to detect elevated intracranial pressure in hypertensive encephalopathy. The neurologic manifestations of preeclampsia and/or eclampsia mimic th
Externí odkaz:
https://doaj.org/article/ee77fe3d202549e1855694a433038c8c
Autor:
Ryan H. Barnes, MD, Joshua A. Shapiro, MD, Nathan Woody, CSSBB, Fei Chen, PhD, Christopher W. Olcott, MD, Daniel J. Del Gaizo, MD
Publikováno v:
Arthroplasty Today, Vol 6, Iss 4, Pp 919-924 (2020)
Background: Opioid addiction is endemic in the United States. We developed a standardized opioid-prescribing schedule (SOPS) after total hip arthroplasty (THA) and total knee arthroplasty (TKA) and evaluated opioid usage alongside Patient-Reported Ou
Externí odkaz:
https://doaj.org/article/0bc90bd5f12a4a87bb5ea694b9a77ce5
Publikováno v:
Case Reports in Orthopedics, Vol 2021 (2021)
Introduction/Cases. Two pediatric patients presenting with benign bone tumors of the distal femur at the level of the suprapatellar fat pad developed late onset recurrent knee hemarthrosis following surgical treatment of the lesions. A sinus tract fr
Externí odkaz:
https://doaj.org/article/80d33f3d1df949f682c5791f5755ecb2
Autor:
Mariarosaria De Rosa, Ryan P. Barnes, Prasanth R. Nyalapatla, Peter Wipf, Patricia L. Opresko
SUMMARYTelomeres are prone to formation of the common oxidative lesion 8-oxoguanine (8oxoG), and the acute production of 8oxoG damage at telomeres is sufficient to drive rapid cellular senescence. OGG1 and MUTYH glycosylases initiate base excision re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f74121c7e50b3237e0ae621c1664890
https://doi.org/10.1101/2023.04.10.536247
https://doi.org/10.1101/2023.04.10.536247
Autor:
Ryan P. Barnes, Mariarosaria de Rosa, Sanjana A. Thosar, Ariana C. Detwiler, Vera Roginskaya, Bennett Van Houten, Marcel P. Bruchez, Jacob Stewart-Ornstein, Patricia L. Opresko
Publikováno v:
Nature Structural & Molecular Biology. 29:639-652
Oxidative stress is a primary cause of cellular senescence and contributes to the etiology of numerous human diseases. Oxidative damage to telomeric DNA has been proposed to cause premature senescence by accelerating telomere shortening. Here, we tes
Neoplastic transformation and genome instability are enhanced by replication stress, conditions that slow or stall DNA replication forks. Consequently, cancer cells require multiple enzymes and checkpoint signaling pathways to mitigate replication st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::506647b5f65dd103b501d89edb9f0e26
https://doi.org/10.1158/0008-5472.c.6510099.v1
https://doi.org/10.1158/0008-5472.c.6510099.v1
Supplementary Table 1 and Figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3671c7e24fa238f430468812995a8db2
https://doi.org/10.1158/0008-5472.22418322.v1
https://doi.org/10.1158/0008-5472.22418322.v1