Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ryan P. Bingham"'
Autor:
Mohammed Ghiboub, Jan Koster, Peter D. Craggs, Andrew Y. F. Li Yim, Anthony Shillings, Sue Hutchinson, Ryan P. Bingham, Kelly Gatfield, Ishtu L. Hageman, Gang Yao, Heather P. O’Keefe, Aaron Coffin, Amish Patel, Lisa A. Sloan, Darren J. Mitchell, Thomas G. Hayhow, Laurent Lunven, Robert J. Watson, Christopher E. Blunt, Lee A. Harrison, Gordon Bruton, Umesh Kumar, Natalie Hamer, John R. Spaull, Danny A. Zwijnenburg, Olaf Welting, Theodorus B. M. Hakvoort, Anje A. te Velde, Johan van Limbergen, Peter Henneman, Rab K. Prinjha, Menno P. J. de Winther, Nicola R. Harker, David F. Tough, Wouter J. de Jonge
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-27 (2022)
Abstract Background SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in the SP140 locus have been linked to Crohn’s disease (CD), suggesting a role in inflammation
Externí odkaz:
https://doaj.org/article/9421aa4ae34c4942a0bffbd856768807
Autor:
Lasse Stach, Emily K. H. Dinley, Nadia Tournier, Ryan P. Bingham, Darren A. Gormley, Jo L. Bramhall, Adam Taylor, Jane E. Clarkson, Katherine A. Welbeck, Claire L. Harris, Maria Feeney, Jane P. Hughes, Armin Sepp, Thil D. Batuwangala, Semra J. Kitchen, Eva-Maria Nichols
Publikováno v:
Antibodies, Vol 10, Iss 4, p 39 (2021)
The terminal pathway of complement is implicated in the pathology of multiple diseases and its inhibition is, therefore, an attractive therapeutic proposition. The practicalities of inhibiting this pathway, however, are challenging, as highlighted by
Externí odkaz:
https://doaj.org/article/9c08d3afb4f34afc913b99f6d81d4c48
Autor:
Jane E Clarkson, Nadia Tournier, Ryan P. Bingham, Maria Feeney, Semra Kitchen, Jo L Bramhall, Darren A. Gormley, Lasse Stach, Eva-Maria Nichols, Jane P. Hughes, Katherine A Welbeck, Claire L. Harris, Adam Taylor, Armin Sepp, Thil D. Batuwangala, Emily K H Dinley
Publikováno v:
Antibodies, Vol 10, Iss 39, p 39 (2021)
Antibodies
Volume 10
Issue 4
Antibodies
Volume 10
Issue 4
The terminal pathway of complement is implicated in the pathology of multiple diseases and its inhibition is, therefore, an attractive therapeutic proposition. The practicalities of inhibiting this pathway, however, are challenging, as highlighted by
Autor:
Paola Nocerino, Iain J. Uings, Ryan P. Bingham, Alessandra Corazza, Diana Canetti, Guglielmo Verona, Palma Mangione, Christopher A. Waudby, John Christodoulou, Vittorio Bellotti, Mark B. Pepys, Graham W. Taylor
Publikováno v:
Journal of Medicinal Chemistry
The wild type protein, transthyretin (TTR), and over 120 genetic TTR variants are amyloidogenic and cause, respectively, sporadic and hereditary systemic TTR amyloidosis. The homotetrameric TTR contains two identical thyroxine binding pockets, occupa
Autor:
Gemma Victoria White, Duncan S. Holmes, Monika Rella, James H. Thorpe, Robert J. Young, Ann Louise Walker, Kathrine J. Smith, Emma V. Edgar, Alain Hovnanian, Oxana Polyakova, Ryan P. Bingham, Yichen Wang, Alan R. Ferrie, John Liddle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1454-1458
The connection between Netherton syndrome and overactivation of epidermal/dermal proteases particularly KLK5 has been well established. To treat sufferers of this severe condition we wished to develop a topical KLK5 inhibitor in order to normalise ep
Autor:
Peter D. Craggs, Faith Mazani, Gabriella Clarke, Carl Haslam, Bhumika Karamshi, Paul Rowland, Sam Rowe, Luke A Greenhough, Ryan P. Bingham, Cassie Messenger, Alexander N Phillipou
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(5)
The predominant assay detection methodologies used for enzyme inhibitor identification during early-stage drug discovery are fluorescence-based. Each fluorophore has a characteristic fluorescence decay, known as the fluorescence lifetime, that occurs
Autor:
Andrew C. Pearce, Alexis Denis, Ann Louise Walker, Pam Nassau, Emma V. Edgar, Anne Marie Jeanne Bouillot, Lionel Trottet, Yichen Wang, Alain Hovnanian, Oxana Polyakova, Marie-Hélène Fouchet, Alexandre Moquette, Duncan S. Holmes, Alan R. Ferrie, Alain Laroze, Kathrine J. Smith, John Liddle, Ryan P. Bingham, Pamela Thomas, James H. Thorpe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:126771
Autor:
Rachel Buxton, Jeremy J. Lambert, Angela Bridges, Rosamund F. Langston, Argyrides Argyrou, Emma J. Jones, Christina Pancevac Jönsson, Susann Schweiger, Olivia Monteiro, Kelly M Gatfield, Changwei Chen, Ryan P. Bingham, Sybille Krauß, Iain Uings
Publikováno v:
Neuroscience letters 673, 44-50 (2018). doi:10.1016/j.neulet.2018.02.061
Expression of mutant Huntingtin (HTT) protein is central to the pathophysiology of Huntington's Disease (HD). The E3 ubiquitin ligase MID1 appears to have a key role in facilitating translation of the mutant HTT mRNA suggesting that interference with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15711b74e62ed0a10bb56478546bb0e5
Autor:
Pam Nassau, Andrew C. Pearce, Lionel Trottet, Ann Louise Walker, Alexis Denis, Duncan S. Holmes, Pamela Thomas, Alan R. Ferrie, Kathrine J. Smith, Alexandre Moquette, James H. Thorpe, Emma V. Edgar, Anne Marie Jeanne Bouillot, Marie-Hélène Fouchet, Alain Laroze, John Liddle, Ryan P. Bingham, Alain Hovnanian, Oxana Polyakova, Yichen Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:126675
The connection between Netherton syndrome and overactivation of epidermal/dermal proteases, particularly Kallikrein 5 (KLK5) has been well established and it is expected that a KLK5 inhibitor would improve the dermal barrier and also reduce the pain
Autor:
Robert P. Davis, Kelly Locke, Rab K. Prinjha, Peter D. Craggs, Gang Yao, Chun-wa Chung, Kenneth E Lind, Oxana Polyakova, Jim E Coote, Daniel J. Slade, Jim Thorpe, John Liddle, David Matthew Wilson, Benjamin D. Bax, Denisa D. Wagner, Kimberly Martinod, Ryan P. Bingham, Yu Hua Chen, Kevin L. Bicker, Claire Maller, Matthew Campbell, Gerard Joberty, Huw D. Lewis, Dirk Eberhard, Martin Rüdiger, Gerard Drewes, Paul R. Thompson, Cecil E Rise, Robert J. Sheppard, Chris Patten, Stephen John Atkinson, Michael David Barker, Pamela Thomas
Publikováno v:
Nature chemical biology
PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have