Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Ryan P O'Connell"'
Autor:
Carl H June, David Weiner, Christopher A Chuckran, Daniel Park, Ryan P O’Connell, Kevin Liaw, Nils Wellhausen, Pratik S Bhojnagarwala, Devivasha Bordoloi, Nicholas Shupin, Daniel Kulp
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 6 (2024)
Background Advanced clear cell renal cell carcinoma (ccRCC) is a prevalent kidney cancer for which long-term survival rates are abysmal, though immunotherapies are showing potential. Not yet clinically vetted are bispecific T cell engagers (BTEs) tha
Externí odkaz:
https://doaj.org/article/e668ca4eaa1e4321a85a2c4dec2793ca
Autor:
Ryan P O'Connell, Hassan Musa, Mario San Martin Gomez, Uma Mahesh Avula, Todd J Herron, Jerome Kalifa, Justus M B Anumonwo
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0133052 (2015)
Epicardial adiposity and plasma levels of free fatty acids (FFAs) are elevated in atrial fibrillation, heart failure and obesity, with potentially detrimental effects on myocardial function. As major components of epicardial fat, FFAs may be abnormal
Externí odkaz:
https://doaj.org/article/78700ceeef024f4c9b09b42787cb12e2
Autor:
Pratik S. Bhojnagarwala, Ryan P. O’Connell, Daniel Park, Kevin Liaw, Ali R. Ali, Devivasha Bordoloi, Joel Cassel, Nicholas J. Tursi, Ebony Gary, David B. Weiner
Publikováno v:
Molecular Therapy: Oncolytics, Vol 26, Iss , Pp 289-301 (2022)
Glioblastoma is an aggressive tumor with poor survival rates. Bispecific T cell engagers (BTEs) against different cancers are in various stages of clinical development. Toxicity resulting from cytokine release syndrome and the short half-life of BTEs
Externí odkaz:
https://doaj.org/article/b08d7aa85d8b4282b67badab3aca7d72
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background Single cell RNA sequencing (scRNAseq) has provided invaluable insights into cellular heterogeneity and functional states in health and disease. During the analysis of scRNAseq data, annotating the biological identity of cell clust
Externí odkaz:
https://doaj.org/article/7e9500ca7bf24a8c93709e7e6bc3067a
Autor:
Daniel H. Park, Kevin Liaw, Pratik Bhojnagarwala, Xizhou Zhu, Jihae Choi, Ali R. Ali, Devivasha Bordoloi, Ebony N. Gary, Ryan P. O’Connell, Abhijeet Kulkarni, Diana Guimet, Trevor Smith, Alfredo Perales-Puchalt, Ami Patel, David B. Weiner
Publikováno v:
Molecular Therapy - Oncolytics. 28:249-263
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d60be24fefbcd155ffcb91cfd2a4bb0
https://doi.org/10.1016/j.omto.2023.02.004
https://doi.org/10.1016/j.omto.2023.02.004
Autor:
Morgan C. Nelson, Ryan M. O'Connell
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Macrophages are key cells of the innate immune system with functional roles in both homeostatic maintenance of self-tissues and inflammatory responses to external stimuli, including infectious agents. Recent advances in metabolic research have reveal
Externí odkaz:
https://doaj.org/article/83e6a0cb3ef3482eb8e87aa98019d159
Autor:
D Garrett Brown, Raymond Soto, Soumya Yandamuri, Colleen Stone, Laura Dickey, Joao Carlos Gomes-Neto, Elissa D Pastuzyn, Rickesha Bell, Charisse Petersen, Kaitlin Buhrke, Robert S Fujinami, Ryan M O'Connell, W Zac Stephens, Jason D Shepherd, Thomas E Lane, June L Round
Publikováno v:
eLife, Vol 8 (2019)
Symbiotic microbes impact the function and development of the central nervous system (CNS); however, little is known about the contribution of the microbiota during viral-induced neurologic damage. We identify that commensals aid in host defense foll
Externí odkaz:
https://doaj.org/article/8f9c877ea32349559ba7e12f43882bd9
Autor:
Devivasha Bordoloi, Pratik S. Bhojnagarwala, Alfredo Perales-Puchalt, Abhijeet J. Kulkarni, Xizhou Zhu, Kevin Liaw, Ryan P. O’Connell, Daniel H. Park, Daniel W. Kulp, Rugang Zhang, David B. Weiner
Publikováno v:
JCI Insight. 7
Despite advances in ovarian cancer (OC) therapy, recurrent OC remains a poor-prognosis disease. Because of the close interaction between OC cells and the tumor microenvironment (TME), it is important to develop strategies that target tumor cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756e28907be230f015c467f9d69f2887
https://doi.org/10.1172/jci.insight.162553
https://doi.org/10.1172/jci.insight.162553
Publikováno v:
J Grad Med Educ
Background Increasing numbers of transgender and nonbinary (TNB) people seek careers in medicine, but little is known about their experiences and the effect of their gender identity during residency application. Objective This project sought to evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3399102b5c0bca6f6745457846e834
https://doi.org/10.4300/jgme-d-20-00384.1
https://doi.org/10.4300/jgme-d-20-00384.1
Autor:
Thomas B. Huffaker, Ruozhen Hu, Marah C. Runtsch, Erin Bake, Xinjian Chen, Jimmy Zhao, June L. Round, David Baltimore, Ryan M. O'Connell
Publikováno v:
Cell Reports, Vol 2, Iss 6, Pp 1697-1709 (2012)
An increased understanding of antitumor immunity is necessary for improving cell-based immunotherapies against human cancers. Here, we investigated the roles of two immune system-expressed microRNAs (miRNAs), miR-155 and miR-146a, in the regulation o
Externí odkaz:
https://doaj.org/article/3066eb1fb52b4a3d9edb71d00409d57f