Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Ryan P Murelli"'
Autor:
Elizabeth Geerling, Valerie Murphy, Maria C Mai, E Taylor Stone, Andreu Gazquez Casals, Mariah Hassert, Austin T O'Dea, Feng Cao, Maureen J Donlin, Mohamed Elagawany, Bahaa Elgendy, Vasiliki Pardali, Erofili Giannakopoulou, Grigoris Zoidis, Daniel V Schiavone, Alex J Berkowitz, Nana B Agyemang, Ryan P Murelli, John E Tavis, Amelia K Pinto, James D Brien
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274266 (2022)
Rift Valley fever virus (RVFV) is a veterinary and human pathogen and is an agent of bioterrorism concern. Currently, RVFV treatment is limited to supportive care, so new drugs to control RVFV infection are urgently needed. RVFV is a member of the or
Externí odkaz:
https://doaj.org/article/f63b08d6f3224485b760c43c8a67f8c2
Autor:
Andreu Gazquez Casals, Alex J. Berkowitz, Alice J. Yu, Hope E. Waters, Daniel V. Schiavone, Diana M. Kapkayeva, Lynda A. Morrison, Ryan P. Murelli
Publikováno v:
RSC Advances. 13:8743-8752
Amide-appended α-hydroxytropolones from a previously described library suppressed herpes simplex virus (HSV) replication in cell culture. A targeted follow-up library led to potent analogs against HSV-1 and -2, including acyclovir-resistant mutants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::843262290307398d0676a3c04ca458fc
https://doi.org/10.1039/d2ra06749h
https://doi.org/10.1039/d2ra06749h
Autor:
Feng Cao, Cari Orth, Maureen J. Donlin, Patrick Adegboyega, Marvin J. Meyers, Ryan P. Murelli, Mohamed Elagawany, Bahaa Elgendy, John E. Tavis
Publikováno v:
ACS Omega, Vol 3, Iss 11, Pp 15125-15133 (2018)
Externí odkaz:
https://doaj.org/article/b20f095983cd4858a4b124a357ad0eac
Publikováno v:
ACS Omega, Vol 1, Iss 3, Pp 435-447 (2016)
Externí odkaz:
https://doaj.org/article/82448fee59e944c19519aaaa5ff991e5
Autor:
Monalisa Swain, Abeer A Ageeli, Wojciech K Kasprzak, Mi Li, Jennifer T Miller, Joanna Sztuba-Solinska, John S Schneekloth, Deepak Koirala, Joseph Piccirili, Americo J Fraboni, Ryan P Murelli, Alexander Wlodawer, Bruce A Shapiro, Nathan Baird, Stuart F J Le Grice
Publikováno v:
Nucleic Acids Res
Cellular and virus-coded long non-coding (lnc) RNAs support multiple roles related to biological and pathological processes. Several lncRNAs sequester their 3′ termini to evade cellular degradation machinery, thereby supporting disease progression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dea3706807e0dc1990b7e0a13320f8
https://doi.org/10.1093/nar/gkab1170
https://doi.org/10.1093/nar/gkab1170
Autor:
Ellen Bak, Jennifer T. Miller, Andrea Noronha, John Tavis, Emilio Gallicchio, Ryan P. Murelli, Stuart F. J. Le Grice
Publikováno v:
Molecules, Vol 25, Iss 19, p 4434 (2020)
Initiation of protein-primed (-) strand DNA synthesis in hepatitis B virus (HBV) requires interaction of the viral reverse transcriptase with epsilon (ε), a cis-acting regulatory signal located at the 5’ terminus of pre-genomic RNA (pgRNA), and se
Externí odkaz:
https://doaj.org/article/c6705b0980124254a3e599d16a659d1c
Publikováno v:
J Org Chem
Oxidopyrylium [5 + 2] cycloaddition reactions are powerful strategies for constructing complex bicyclic architectures. However, intermolecular cycloadditions of oxidopyrylium ylides are limited due to competing dimerization processes; consequently, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495b999b6c7ae7c857408093a781596a
https://doi.org/10.1021/acs.joc.0c02655
https://doi.org/10.1021/acs.joc.0c02655
Publikováno v:
Organic Syntheses. :1-17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73802d7471501267284886463a0ec292
https://doi.org/10.1002/0471264229.os096.30
https://doi.org/10.1002/0471264229.os096.30
Autor:
Daniel V. Schiavone, Diana M. Kapkayeva, Qilan Li, Molly E. Woodson, Andreu Gazquez Casals, Lynda A. Morrison, John E. Tavis, Ryan P. Murelli
Publikováno v:
Chemistry
Polyoxygenated tropolones possess a broad range of biological activity, and as a result are promising lead structures or fragments for drug development. However, structure-function studies and subsequent optimization have been challenging, in part du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5e8d6296875d885c8561e019f36687
https://europepmc.org/articles/PMC8858858/
https://europepmc.org/articles/PMC8858858/
Autor:
Austin T O'Dea, Nathan L. Ponzar, John E. Tavis, Molly E Woodson, Bruce L Rogers, Daniel P Bradley, Ryan P. Murelli, Alaina Knier, Qilan Li
Publikováno v:
Antimicrob Agents Chemother
The α-hydroxytropolones (αHTs) are troponoid inhibitors of hepatitis B virus (HBV) replication that can target HBV RNase H with submicromolar efficacies. αHTs and related troponoids (tropones and tropolones) can be cytotoxic in cell lines as measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6696a7e64c277ee7f73da06f83f52f
https://europepmc.org/articles/PMC8765277/
https://europepmc.org/articles/PMC8765277/