Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ryan P Lewandowski"'
Autor:
Kristen N Gilley, Kathryn A Wierenga, Preeti S Chauhuan, James G Wagner, Ryan P Lewandowski, Elizbeth A Ross, A L Lock, Jack R Harkema, Abby D Benninghoff, James J Pestka
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233183 (2020)
Lupus is a debilitating multi-organ autoimmune disease clinically typified by periods of flare and remission. Exposing lupus-prone female NZBWF1 mice to crystalline silica (cSiO2), a known human autoimmune trigger, mimics flaring by inducing interfer
Externí odkaz:
https://doaj.org/article/c24d4cdb1595420c98ffbc65a67b2209
Autor:
Lauren K. Heine, Lichchavi D. Rajasinghe, James G. Wagner, Ryan P. Lewandowski, Quan-Zhen Li, Alexa L. Richardson, Ashleigh N. Tindle, Jenan J. Shareef, Jack R. Harkema, James J. Pestka
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
Lupus, a systemic autoimmune disease shaped by gene-environment interplay, often progresses to endstage renal failure. While subchronic systemic exposure to bacterial lipopolysaccharide (LPS) triggers autoimmunity and glomerulonephritis in lupus-pron
Externí odkaz:
https://doaj.org/article/24dd03243e4e46369e01de89b45b93c9
Autor:
Preeti S. Chauhan, Abby D. Benninghoff, Olivia K. Favor, James G. Wagner, Ryan P. Lewandowski, Lichchavi D. Rajasinghe, Quan-Zhen Li, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionWorkplace exposure to respirable crystalline silica (cSiO2) has been epidemiologically linked to lupus. Consistent with this, repeated subchronic intranasal cSiO2 instillation in lupus-prone NZBWF1 mice induces inflammation-/autoimmune-re
Externí odkaz:
https://doaj.org/article/1e54e2a2b11e4dc2b1e9f441abbd8a28
Autor:
Olivia K. Favor, Preeti S. Chauhan, Elham Pourmand, Angel M. Edwards, James G. Wagner, Ryan P. Lewandowski, Lauren K. Heine, Jack R. Harkema, Kin Sing Stephen Lee, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionLipopolysaccharide (LPS)-accelerated autoimmune glomerulonephritis (GN) in NZBWF1 mice is a preclinical model potentially applicable for investigating lipidome-modulating interventions against lupus. LPS can be expressed as one of two che
Externí odkaz:
https://doaj.org/article/833e51e1555d4f3481899efdb941de51
Autor:
Lauren K. Heine, Abby D. Benninghoff, Elizabeth A. Ross, Lichchavi D. Rajasinghe, James G. Wagner, Ryan P. Lewandowski, Alexa L. Richardson, Quan-Zhen Li, John P. Buchweitz, Justin Zyskowski, Ashleigh N. Tindle, Anna E. Skedel, Nicholas J. Chargo, Laura R. McCabe, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in immunology. 13
Autoimmune diseases can be triggered by environmental toxicants such as crystalline silica dust (cSiO2). Here, we characterized the dose-dependent immunomodulation and toxicity of the glucocorticoid (GC) prednisone in a preclinical model that emulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e521a0d4ef3878e7641b1f16138618e8
https://pubmed.ncbi.nlm.nih.gov/36341330
https://pubmed.ncbi.nlm.nih.gov/36341330
Autor:
Carine Holz, Ning Li, Arthur K. Cho, Daven N. Jackson-Humbles, Damansher Sidhu, John R. Froines, James G. Wagner, Ryan P. Lewandowski, Arantzazu Eiguren-Fernandez, Peyman Akbari, Jack R. Harkema
Publikováno v:
Toxicology letters. 356
Although exposure to ambient particulate matter (PM) is linked to asthma, the health effects of co-existing vapor-phase organic pollutants (vapor) and their combined effects with PM on this disease are poorly understood. We used a murine asthma model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3211ffacc4f97c08fe26c6bbae0d3601
https://pubmed.ncbi.nlm.nih.gov/34863859
https://pubmed.ncbi.nlm.nih.gov/34863859
Autor:
L. Ross, A. Richardson, Jack R. Harkema, L.K. Heine, A. Tindle, James J. Pestka, Ryan P. Lewandowski, James G. Wagner
Publikováno v:
TP61. TP061 RESIDENTIAL AND OCCUPATIONAL EXPOSURES: WHERE WE LIVE, WORK, AND BREATHE.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d4e9137bdd8a6b889002c048db2437
https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3044
https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3044
Autor:
James J. Pestka, Peyman Akbari, Kathryn A. Wierenga, Melissa A. Bates, Kristen. N. Gilley, James G. Wagner, Ryan P. Lewandowski, Lichchavi D. Rajasinghe, Preeti S. Chauhan, Adam L. Lock, Quan-Zhen Li, Jack R. Harkema
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Workplace exposure to respirable crystalline silica dust (cSiO2) has been etiologically linked to the development of lupus and other human autoimmune diseases. Lupus triggering can be recapitulated in female NZBWF1 mice by four weekly intranasal inst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611bb3826988ef5b2ca04bbfa43aacfc
Autor:
Preeti S. Chauhan, James G. Wagner, Abby D. Benninghoff, Ryan P. Lewandowski, Olivia K. Favor, Kathryn A. Wierenga, Kristen N. Gilley, Elizabeth A. Ross, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Occupational exposure to crystalline silica (cSiO2) is etiologically associated with systemic lupus erythematosus (lupus) and other autoimmune diseases. cSiO2's autoimmune effects in humans can be mimicked chronically in female lupus-prone NZBWF1 mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc396f40463361b6eb8f9c0b955d5e9c
https://www.frontiersin.org/articles/10.3389/fimmu.2021.635138/full
https://www.frontiersin.org/articles/10.3389/fimmu.2021.635138/full
Autor:
Christina E. Barkauskas, Ryan P. Lewandowski, Jack R. Harkema, James G. Wagner, Aaron Vose, Robert M. Tighe
Publikováno v:
Environmental Health Perspectives
Background: Epidemiological studies support the hypothesis that diabetes alters pulmonary responses to air pollutants like ozone (O3). The mechanism(s) underlying these associations and potential links among diabetes, O3, and lung inflammation and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc86bc7a9f74f647e36d354128afb80b
http://europepmc.org/articles/PMC7703867
http://europepmc.org/articles/PMC7703867