Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ryan P Duren"'
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150450 (2016)
Members of the NR4A subfamily of orphan nuclear receptors regulate cell fate decisions via both genomic and non-genomic mechanisms in a cell and tissue selective manner. NR4As play a key role in maintenance of hematopoietic stem cell homeostasis and
Externí odkaz:
https://doaj.org/article/f0d381b28ead481986458c3ffa7de2b3
Autor:
Susan M. Mockus, Deborah I. Ritter, David Tamborero, Obi L. Griffith, Jeremy Goecks, Gordana Raca, Damian T. Rieke, Georgia Mayfield, Nuria Lopez-Bigas, Jianjiong Gao, Kilannin Krysiak, Melissa A. Haendel, Ryan P Duren, Olivier Elemento, Kyle Ellrott, Jordi Deu-Pons, Adam A. Margolin, Brian Walsh, Tero Aittokallio, Michael Baudis, Rodrigo Dienstmann, Subha Madhavan, Julie A. McMurry, Sara E. Patterson, Ethan Cerami, Ozman Ugur Sezerman, Robert R. Freimuth, Beth A. Pitel, Nikolaus Schultz, Lynn M. Schriml, Alex H. Wagner, Jeremy L. Warner, Mark Lawler, Jacques S. Beckmann, Dmitriy Sonkin, Catherine Del Vecchio Fitz, Xuan Shirley Li, Debyani Chakravarty, Malachi Griffith
Publikováno v:
Variant Interpretation for Cancer Consortium 2020, ' A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer ', Nature Genetics, vol. 52, no. 4, pp. 448-457 . https://doi.org/10.1038/s41588-020-0603-8
Nature Genetics
Nature genetics, vol. 52, no. 4, pp. 448-457
Scientia
Nature Genetics
Nature genetics, vol. 52, no. 4, pp. 448-457
Scientia
Precision oncology relies on accurate discovery and interpretation of genomic variants, enabling individualized diagnosis, prognosis and therapy selection. We found that six prominent somatic cancer variant knowledgebases were highly disparate in con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37b4128ca2649aae6483eb7ae33b29f
https://pure.qub.ac.uk/en/publications/eac9e539-6ee6-4236-a0fc-64fa11bb778e
https://pure.qub.ac.uk/en/publications/eac9e539-6ee6-4236-a0fc-64fa11bb778e
Autor:
Loc Nguyen, Anil K. Panigrahi, Pablo R. Freire, Ryan P. Duren, Orla M. Conneely, Cristian Coarfa, S. Greg Call, Sandra L. Grimm
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Epigenetic reprogramming in Acute Myeloid Leukemia (AML) leads to the aberrant activation of super enhancer (SE) landscapes that drive the expression of key oncogenes, including the oncogenic MYC pathway. These SEs have been identified as promising t
Autor:
Michele S. Redell, Steven G Call, Ryan P. Duren, Loc Nguyen, Pablo R. Freire, Seth P. Boudreaux, Orla M. Conneely, Padmini Narayanan
Publikováno v:
Leukemia
NR4As are AML tumor suppressors that are frequently silenced in human acute myeloid leukemia (AML). Despite their potential as novel targets for therapeutic intervention, mechanisms of NR4A silencing and strategies for their reactivation remain poorl
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0150450 (2016)
PLoS ONE, Vol 11, Iss 3, p e0150450 (2016)
Members of the NR4A subfamily of orphan nuclear receptors regulate cell fate decisions via both genomic and non-genomic mechanisms in a cell and tissue selective manner. NR4As play a key role in maintenance of hematopoietic stem cell homeostasis and
Autor:
Orla M. Conneely, Ryan P. Duren
Publikováno v:
Cancer Research. 74:LB-83
Acute myeloid leukemias are a highly heterogeneous group of diseases associated with corruption of myeloid cell differentiation, accumulation of immature blasts, and emergence of a transformed leukemia initiating cell (LIC) capable of sustaining leuk
Publikováno v:
Oncogenesis
Acute myeloid leukemias (AMLs) are a heterogeneous group of diseases that are sustained by relatively rare leukemia-initiating cells (LICs) that exhibit diverse genetic and phenotypic properties. AML heterogeneity presents a major challenge to develo