Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Ryan Owen"'
Autor:
Fei Tang, Rebecca Kunder, Tom Chu, Avis Hains, Allen Nguyen, Jacqueline M. McBride, Yu Zhong, Sara Santagostino, Maria Wilson, Abigail Trenchak, Liuxi Chen, Justin Ly, Anita Moein, Nicholas Lewin‐Koh, Vibha Raghavan, Uyi Osaghae, Chris Wynne, Ryan Owen, David Place
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 9, Pp 1653-1666 (2023)
Abstract Inappropriate and chronic activation of the cytosolic NOD‐, LRR‐, and pyrin domain‐containing 3 (NLRP3) inflammasome, a key component of innate immunity, likely underlies several inflammatory diseases, including coronary artery disease
Externí odkaz:
https://doaj.org/article/7a96997b4ebb4093a90b5db4a16716a5
Autor:
Elise Oh, Russ Wada, Kha Le, Yanan Zheng, Jin Jin, Victor Poon, Kit Wong, Ryan Owen, Kenta Yoshida
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 6, Pp 795-807 (2023)
Abstract The pharmacokinetic (PK) characteristics of omalizumab and its pharmacodynamic (PD) effect in patients has yet to be fully characterized in chronic spontaneous urticaria, which could elucidate its pathogenesis and treatment response. This st
Externí odkaz:
https://doaj.org/article/a67e26c5a2c441d681efc08a0ea0d46f
Autor:
Sharon M. Rymut, Lindsay M. Henderson, Victor Poon, Tracy L. Staton, Fang Cai, Siddharth Sukumaran, Horace Rhee, Ryan Owen, Saroja Ramanujan, Kenta Yoshida
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 4, Pp 694-703 (2023)
Abstract Tryptase, a protease implicated in asthma pathology, is secreted from mast cells upon activation during an inflammatory allergic response. MTPS9579A is a novel monoclonal antibody that inhibits tryptase activity by irreversibly dissociating
Externí odkaz:
https://doaj.org/article/9f61ef52477747f58a911a9bf124e120
Autor:
Rui Zhu, Hubert Chen, Joshua Galanter, Gaohong She, Fang Cai, Matthew R. Durk, Yixuan Zou, Liuxi Chen, Jane R. Kenny, Shweta Vadhavkar, Simon Warren, Glyn Taylor, Olivia Hwang, Avi Eliahu, Chris Wynne, Ryan Owen
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 5, Pp 1225-1237 (2022)
Abstract Several inflammatory cytokines that promote inflammation and pathogenesis in asthma signal through the Janus kinase 1 (JAK1) pathway. This phase I, randomized, placebo‐controlled trial assessed the pharmacokinetics and safety of single and
Externí odkaz:
https://doaj.org/article/86f1d4d5c4f542fca1040d064b72434f
Publikováno v:
Urology Case Reports, Vol 46, Iss , Pp 102321- (2023)
Emphysematous cystitis (EC) is a bladder pathology typically resulting from gas-producing bacterial infections. Risk factors include female gender, age greater than 60, diabetes mellitus, glycosuria, and urinary stasis. If not addressed promptly, it
Externí odkaz:
https://doaj.org/article/f8ab85bca3a34214be12e895f3037d7b
Publikováno v:
Case Reports in Nephrology and Dialysis, Vol 11, Iss 1, Pp 16-25 (2021)
Lupus nephritis (LN) and the collapsing variant of focal segmental glomerulosclerosis (cFSGS) are separate histologic diagnoses that are generally thought to have separate etiologies. We describe the presentation of a 20-year-old African American fem
Externí odkaz:
https://doaj.org/article/c9d27add83d6408786a9fe287d52ec6e
Autor:
Tracy L. Staton, Kun Peng, Ryan Owen, David F. Choy, Christopher R. Cabanski, Alice Fong, Flavia Brunstein, Kathila R. Alatsis, Hubert Chen
Publikováno v:
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-16 (2019)
Abstract Background Inhibition of interleukin (IL)-13, a Type 2 inflammatory mediator in asthma, improves lung function and reduces exacerbations; however, more effective therapies are needed. A subset of asthma patients also exhibits elevated IL-17,
Externí odkaz:
https://doaj.org/article/a7047a62425c46428a3a3ea92002c7fd
Autor:
Sharon M. Rymut, Lindsay M. Henderson, Victor Poon, Tracy L. Staton, Fang Cai, Siddharth Sukumaran, Horace Rhee, Ryan Owen, Saroja Ramanujan, Kenta Yoshida
Publikováno v:
Clinical and Translational Science. 16:694-703
Autor:
Fei Tang, Jurgen Langenhorst, Steve Dang, Nastya Kassir, Ryan Owen, Barbara Purdon, Mats O. Magnusson, Rong Deng
Publikováno v:
The Journal of Clinical Pharmacology. 63:197-209
The pharmacokinetics (PK) of tenecteplase in patients with acute ischemic stroke has not been extensively studied. This study aimed to describe PK characteristics of tenecteplase in patients with acute myocardial infarction (AMI) using a population P
Autor:
Beyrer, Chris, Baral, Stefan D, Collins, Chris, Richardson, Eugene T, Sullivan, Patrick S, Sanchez, Jorge, Trapence, Gift, Katabira, Elly, Kazatchkine, Michel, Ryan, Owen, Wirtz, Andrea L, Mayer, Kenneth H
Publikováno v:
In The Lancet 9-15 July 2016 388(10040):198-206