Zobrazeno 1 - 10
of 2 152
pro vyhledávání: '"Ryan O"'
Autor:
Bradley R. Groveman, Katie Williams, Brent Race, Simote Foliaki, Tina Thomas, Andrew G. Hughson, Ryan O. Walters, Wenquan Zou, Cathryn L. Haigh
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 6, Pp 1193-1202 (2024)
Chronic wasting disease (CWD) is a cervid prion disease with unknown zoonotic potential that might pose a risk to humans who are exposed. To assess the potential of CWD to infect human neural tissue, we used human cerebral organoids with 2 different
Externí odkaz:
https://doaj.org/article/670bd8c3967d4f188129ce606ca89fd1
Autor:
Clay D Jackson-Litteken, Wanfeng Guo, Brandon A Hogland, C Tyler Ratliff, LeAnn McFadden, Marissa S Fullerton, Daniel E Voth, Ryan O M Rego, Jon S Blevins
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 7, p e0012348 (2024)
Relapsing fever (RF), a vector-borne disease caused by Borrelia spp., is characterized by recurring febrile episodes due to repeated bouts of bacteremia. RF spirochetes can be geographically and phylogenetically divided into two distinct groups; Old
Externí odkaz:
https://doaj.org/article/96b34f5dc8854deaa9812a5f61955f9a
Autor:
Alejandra Wu-Chuang, Lourdes Mateos-Hernandez, Apolline Maitre, Ryan O. M. Rego, Radek Šíma, Stefania Porcelli, Sabine Rakotobe, Angélique Foucault-Simonin, Sara Moutailler, Vaidas Palinauskas, Justė Aželytė, Ladislav Sǐmo, Dasiel Obregon, Alejandro Cabezas-Cruz
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract Background Ticks can transmit a broad variety of pathogens of medical importance, including Borrelia afzelii, the causative agent of Lyme borreliosis in Europe. Tick microbiota is an important factor modulating, not only vector physiology, b
Externí odkaz:
https://doaj.org/article/6b6819bf1dc747bea377c97d5c6c1712
Autor:
Christopher B Zinck, Prasobh Raveendram Thampy, Eva-Maria E Uhlemann, Hesham Adam, Jenny Wachter, Danae Suchan, Andrew D S Cameron, Ryan O M Rego, Dustin Brisson, Catherine Bouchard, Nicholas H Ogden, Maarten J Voordouw
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011572 (2023)
Pathogen life history theory assumes a positive relationship between pathogen load in host tissues and pathogen transmission. Empirical evidence for this relationship is surprisingly rare due to the difficulty of measuring transmission for many patho
Externí odkaz:
https://doaj.org/article/ff323a5f45314a72b5ff1b3a05ac2aa8
Autor:
Simote T. Foliaki, Aleksandar Wood, Katie Williams, Anna Smith, Ryan O. Walters, Chase Baune, Bradley R. Groveman, Cathryn L. Haigh
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102733- (2023)
Cellular prion protein (PrPC) protects neurons against oxidative stress damage. This role is lost upon its misfolding into insoluble prions in prion diseases, and correlated with cytoskeletal breakdown and neurophysiological deficits. Here we used mo
Externí odkaz:
https://doaj.org/article/434f51e1d13442429fb7e4e62f8c8170
Autor:
Aleksandar R. Wood, Simote T. Foliaki, Bradley R. Groveman, Ryan O. Walters, Katie Williams, Jue Yuan, Wen-Quan Zou, Cathryn L. Haigh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Cardiomyopathy is a co-morbidity of some prion diseases including genetic disease caused by mutations within the PrP gene (PRNP). Although the cellular prion protein (PrP) has been shown to protect against cardiotoxicity caused by oxidative
Externí odkaz:
https://doaj.org/article/882680c5df1d458ba3fb9ad953652c19
Autor:
Ryan O. Snodgrass, Karan Govindpani, Karen Plant, Elisabeth C. Kugler, Changmin Doh, Thomas Dawson, Luis E. McCormack, Helen M. Arthur, Timothy J. A. Chico
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/ee242943edf346f0a36a4522901556da
Autor:
Chandler D. Gatenbee, Ann-Marie Baker, Ryan O. Schenck, Maximilian Strobl, Jeffrey West, Margarida P. Neves, Sara Yakub Hasan, Eszter Lakatos, Pierre Martinez, William C. H. Cross, Marnix Jansen, Manuel Rodriguez-Justo, Christopher J. Whelan, Andrea Sottoriva, Simon Leedham, Mark Robertson-Tessi, Trevor A. Graham, Alexander R. A. Anderson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Integration of mathematical modeling, ecological analyses of patient biopsies, and neoantigen heterogeneity suggests recruitment of immunosuppressive cells is key to initializing transformation from adenoma to carcinoma in human colorectal cancer.
Externí odkaz:
https://doaj.org/article/dec007baa85d4e4e91b6bac2af9bca15
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/029fbf18773b467a94bf46230bdd271d
Autor:
Simote T. Foliaki, Benjamin Schwarz, Bradley R. Groveman, Ryan O. Walters, Natalia C. Ferreira, Christina D. Orrù, Anna Smith, Aleksandar Wood, Olivia M. Schmit, Phoebe Freitag, Jue Yuan, Wenquan Zou, Catharine M. Bosio, James A. Carroll, Cathryn L. Haigh
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-23 (2021)
Abstract The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to explore these properties using cerebral organoids (COs) derived from fibroblasts of individuals wi
Externí odkaz:
https://doaj.org/article/6bd0dd66c2cd46cbb517d6bd6b03291d