Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Ryan N. Gutenkunst"'
Publikováno v:
Human Genomics, Vol 12, Iss 1, Pp 1-9 (2018)
Abstract The past decade has seen major investment in genome-wide association studies (GWAS). Among the many goals of GWAS, a major one is to identify and motivate research on novel genes involved in complex human disease. To assess whether this goal
Externí odkaz:
https://doaj.org/article/8730b33903494f8faf056f0aac905991
Autor:
M Elise Lauterbur, Maria Izabel A Cavassim, Ariella L Gladstein, Graham Gower, Nathaniel S Pope, Georgia Tsambos, Jeffrey Adrion, Saurabh Belsare, Arjun Biddanda, Victoria Caudill, Jean Cury, Ignacio Echevarria, Benjamin C Haller, Ahmed R Hasan, Xin Huang, Leonardo Nicola Martin Iasi, Ekaterina Noskova, Jana Obsteter, Vitor Antonio Correa Pavinato, Alice Pearson, David Peede, Manolo F Perez, Murillo F Rodrigues, Chris CR Smith, Jeffrey P Spence, Anastasia Teterina, Silas Tittes, Per Unneberg, Juan Manuel Vazquez, Ryan K Waples, Anthony Wilder Wohns, Yan Wong, Franz Baumdicker, Reed A Cartwright, Gregor Gorjanc, Ryan N Gutenkunst, Jerome Kelleher, Andrew D Kern, Aaron P Ragsdale, Peter L Ralph, Daniel R Schrider, Ilan Gronau
Publikováno v:
eLife, Vol 12 (2023)
Simulation is a key tool in population genetics for both methods development and empirical research, but producing simulations that recapitulate the main features of genomic datasets remains a major obstacle. Today, more realistic simulations are pos
Externí odkaz:
https://doaj.org/article/ed75e3569fbf474782ef3b9546fe2394
Inferring past demographic history of natural populations from genomic data is of central concern in many studies across research fields. Previously, our group had developed dadi, a widely used demographic history inference method based on the allele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5549c60fa6c4156fea1c1aaaea4d7826
https://doi.org/10.1101/2023.05.24.542158
https://doi.org/10.1101/2023.05.24.542158
Autor:
Nina Marchi, Laura Winkelbach, Ilektra Schulz, Maxime Brami, Zuzana Hofmanová, Jens Blöcher, Carlos S. Reyna-Blanco, Yoan Diekmann, Alexandre Thiéry, Adamandia Kapopoulou, Vivian Link, Valérie Piuz, Susanne Kreutzer, Sylwia M. Figarska, Elissavet Ganiatsou, Albert Pukaj, Travis J. Struck, Ryan N. Gutenkunst, Necmi Karul, Fokke Gerritsen, Joachim Pechtl, Joris Peters, Andrea Zeeb-Lanz, Eva Lenneis, Maria Teschler-Nicola, Sevasti Triantaphyllou, Sofija Stefanović, Christina Papageorgopoulou, Daniel Wegmann, Joachim Burger, Laurent Excoffier
Publikováno v:
Marchi, Nina; Winkelbach, Laura; Schulz, Ilektra; Brami, Maxime; Hofmanová, Zuzana; Blöcher, Jens; Reyna-Blanco, Carlos S.; Diekmann, Yoan; Thiéry, Alexandre; Kapopoulou, Adamandia; Link, Vivian; Piuz, Valérie; Kreutzer, Susanne; Figarska, Sylwia M.; Ganiatsou, Elissavet; Pukaj, Albert; Struck, Travis J.; Gutenkunst, Ryan N.; Karul, Necmi; Gerritsen, Fokke; ... (2022). The genomic origins of the world’s first farmers. Cell, 185(11), 1842-1859.e18. Cell Press 10.1016/j.cell.2022.04.008
Marchi, N, Winkelbach, L, Schulz, I, Brami, M, Hofmanová, Z, Blöcher, J, Reyna-Blanco, C S, Diekmann, Y, Thiéry, A, Kapopoulou, A, Link, V, Piuz, V, Kreutzer, S, Figarska, S M, Ganiatsou, E, Pukaj, A, Struck, T J, Gutenkunst, R N, Karul, N, Gerritsen, F, Pechtl, J, Peters, J, Zeeb-Lanz, A, Lenneis, E, Teschler-Nicola, M, Triantaphyllou, S, Stefanović, S, Papageorgopoulou, C, Wegmann, D, Burger, J & Excoffier, L 2022, ' The genomic origins of the world's first farmers ', Cell, vol. 185, no. 11, pp. 1842-1859 . https://doi.org/10.1016/j.cell.2022.04.008
Cell, 185(11), 1842-1859. Cell Press
Cell, 185 (11)
Cell
Marchi, N, Winkelbach, L, Schulz, I, Brami, M, Hofmanová, Z, Blöcher, J, Reyna-Blanco, C S, Diekmann, Y, Thiéry, A, Kapopoulou, A, Link, V, Piuz, V, Kreutzer, S, Figarska, S M, Ganiatsou, E, Pukaj, A, Struck, T J, Gutenkunst, R N, Karul, N, Gerritsen, F, Pechtl, J, Peters, J, Zeeb-Lanz, A, Lenneis, E, Teschler-Nicola, M, Triantaphyllou, S, Stefanović, S, Papageorgopoulou, C, Wegmann, D, Burger, J & Excoffier, L 2022, ' The genomic origins of the world's first farmers ', Cell, vol. 185, no. 11, pp. 1842-1859 . https://doi.org/10.1016/j.cell.2022.04.008
Cell, 185(11), 1842-1859. Cell Press
Cell, 185 (11)
Cell
The precise genetic origins of the first Neolithic farming populations in Europe and Southwest Asia, as well as the processes and the timing of their differentiation, remain largely unknown. Demogenomic modeling of high-quality ancient genomes reveal
Autor:
Prata K, Kelly R. W. Latijnhouwers, Cynthia Riginos, Sánchez J, Ryan N. Gutenkunst, Kyra B. Hay, Norbert Englebert, Pim Bongaerts
Publikováno v:
Molecular Ecology. 31:2511-2527
Largely understudied, mesophotic coral ecosystems lie below shallow reefs (at30 m depth) and comprise ecologically distinct communities. Brooding reproductive modes appear to predominate among mesophotic-specialist corals and may limit genetic connec
Autor:
M. Elise Lauterbur, Maria Izabel A. Cavassim, Ariella L. Gladstein, Graham Gower, Nathaniel S. Pope, Georgia Tsambos, Jeff Adrion, Saurabh Belsare, Arjun Biddanda, Victoria Caudill, Jean Cury, Ignacio Echevarria, Benjamin C. Haller, Ahmed R. Hasan, Xin Huang, Leonardo Nicola Martin Iasi, Ekaterina Noskova, Jana Obšteter, Vitor Antonio Corrêa Pavinato, Alice Pearson, David Peede, Manolo F. Perez, Murillo F. Rodrigues, Chris C. R. Smith, Jeffrey P. Spence, Anastasia Teterina, Silas Tittes, Per Unneberg, Juan Manuel Vazquez, Ryan K. Waples, Anthony Wilder Wohns, Yan Wong, Franz Baumdicker, Reed A. Cartwright, Gregor Gorjanc, Ryan N. Gutenkunst, Jerome Kelleher, Andrew D. Kern, Aaron P. Ragsdale, Peter L. Ralph, Daniel R. Schrider, Ilan Gronau
Publikováno v:
Lauterbur, M E, Cavassim, M I A, Gladstein, A L, Gower, G, Pope, N S, Tsambos, G, Adrion, J, Belsare, S, Biddanda, A, Caudill, V, Cury, J, Echevarria, I, Haller, B C, Hasan, A R, Huang, X, Iasi, L N M, Noskova, E, Obsteter, J, Pavinato, V A C, Pearson, A, Peede, D, Perez, M F, Rodrigues, M F, Smith, C C R, Spence, J P, Teterina, A, Tittes, S, Unneberg, P, Vazquez, J M, Waples, R K, Wohns, A W, Wong, Y, Baumdicker, F, Cartwright, R A, Gorjanc, G, Gutenkunst, R N, Kelleher, J, Kern, A D, Ragsdale, A P, Ralph, P L, Schrider, D R & Gronau, I 2023, ' Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations ', eLIFE, vol. 12, no. RP84874, pp. 1-20 . https://doi.org/10.7554/eLife.84874
eLife
Lauterbur, M E, Cavassim, M I A, Gladstein, A L, Gower, G, Pope, N S, Tsambos, G, Adrion, J, Belsare, S, Biddanda, A, Caudill, V, Cury, J, Echevarria, I, Haller, B C, Hasan, A R, Huang, X, Iasi, L N M, Noskova, E, Obsteter, J, Pavinato, V A C, Pearson, A, Peede, D, Perez, M F, Rodrigues, M F, Smith, C C R, Spence, J P, Teterina, A, Tittes, S, Unneberg, P, Vazquez, J M, Waples, R K, Wohns, A W, Wong, Y, Baumdicker, F, Cartwright, R A, Gorjanc, G, Gutenkunst, R N, Kelleher, J, Kern, A D, Ragsdale, A P, Ralph, P L, Schrider, D R & Gronau, I 2023, ' Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations ', eLife, vol. 12, RP84874 . https://doi.org/10.7554/eLife.84874
eLife
Lauterbur, M E, Cavassim, M I A, Gladstein, A L, Gower, G, Pope, N S, Tsambos, G, Adrion, J, Belsare, S, Biddanda, A, Caudill, V, Cury, J, Echevarria, I, Haller, B C, Hasan, A R, Huang, X, Iasi, L N M, Noskova, E, Obsteter, J, Pavinato, V A C, Pearson, A, Peede, D, Perez, M F, Rodrigues, M F, Smith, C C R, Spence, J P, Teterina, A, Tittes, S, Unneberg, P, Vazquez, J M, Waples, R K, Wohns, A W, Wong, Y, Baumdicker, F, Cartwright, R A, Gorjanc, G, Gutenkunst, R N, Kelleher, J, Kern, A D, Ragsdale, A P, Ralph, P L, Schrider, D R & Gronau, I 2023, ' Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations ', eLife, vol. 12, RP84874 . https://doi.org/10.7554/eLife.84874
Simulation is a key tool in population genetics for both methods development and empirical research, but producing simulations that recapitulate the main features of genomic data sets remains a major obstacle. Today, more realistic simulations are po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8243d8d49970ab6eb1bb1ba7366c0d8f
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-508060
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-508060
Autor:
Graham Gower, Aaron P. Ragsdale, Gertjan Bisschop, Ryan N. Gutenkunst, Matthew Hartfield, Ekaterina Noskova, Stephan Schiffels, Travis J. Struck, Jerome Kelleher, Kevin R. Thornton
Publikováno v:
Genetics, vol 222, iss 3
Gower, G, Ragsdale, A P, Bisschop, G, Gutenkunst, R N, Hartfield, M, Noskova, E, Schiffels, S, Struck, T J, Kelleher, J & Thornton, K R 2022, ' Demes : a standard format for demographic models ', Genetics, vol. 222, no. 3, iyac131 . https://doi.org/10.1093/genetics/iyac131
Genetics
Gower, G, Ragsdale, A P, Gutenkunst, R N, Hartfield, M, Noskova, E, Struck, T J, Kelleher, J & Thornton, K R 2022, ' Demes : A standard format for demographic models ', Genetics, vol. 222, no. 3, iyac131 . https://doi.org/10.1093/genetics/iyac131
Gower, G, Ragsdale, A P, Bisschop, G, Gutenkunst, R N, Hartfield, M, Noskova, E, Schiffels, S, Struck, T J, Kelleher, J & Thornton, K R 2022, ' Demes : a standard format for demographic models ', Genetics, vol. 222, no. 3, iyac131 . https://doi.org/10.1093/genetics/iyac131
Genetics
Gower, G, Ragsdale, A P, Gutenkunst, R N, Hartfield, M, Noskova, E, Struck, T J, Kelleher, J & Thornton, K R 2022, ' Demes : A standard format for demographic models ', Genetics, vol. 222, no. 3, iyac131 . https://doi.org/10.1093/genetics/iyac131
Understanding the demographic history of populations is a key goal in population genetics, and with improving methods and data, ever more complex models are being proposed and tested. Demographic models of current interest typically consist of a set
Recent experimental evidence demonstrates that shifts in mutational biases, for example increases in transversion frequency, can change the distribution of fitness effects of mutations (DFE). In particular, reducing or reversing a prevailing bias can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb45b3ada7d5523d304a0b942ce8ea0
https://doi.org/10.1101/2022.09.27.509708
https://doi.org/10.1101/2022.09.27.509708
As a consequence of the process of domestication, wild and domestic individuals are adapted to very different environmental conditions. Although the phenotypic consequences of domestication are observable, the genetic causes are not evident in many c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f06bdc094e94cc7f6cd02527cc39e493
https://doi.org/10.1101/2022.08.24.505198
https://doi.org/10.1101/2022.08.24.505198
Autor:
Megan N. Irby, Travis J. Struck, Jennifer E. James, Alyssa Lyn Fortier, José E. León-Burguete, Ryan N. Gutenkunst, Xin Huang, Alec J. Coffman, Aaron P. Ragsdale
Publikováno v:
Molecular Biology and Evolution
The effect of a mutation on fitness may differ between populations depending on environmental and genetic context, but little is known about the factors that underlie such differences. To quantify genome-wide correlations in mutation fitness effects,