Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Ryan N Gutenkunst"'
Autor:
M Elise Lauterbur, Maria Izabel A Cavassim, Ariella L Gladstein, Graham Gower, Nathaniel S Pope, Georgia Tsambos, Jeffrey Adrion, Saurabh Belsare, Arjun Biddanda, Victoria Caudill, Jean Cury, Ignacio Echevarria, Benjamin C Haller, Ahmed R Hasan, Xin Huang, Leonardo Nicola Martin Iasi, Ekaterina Noskova, Jana Obsteter, Vitor Antonio Correa Pavinato, Alice Pearson, David Peede, Manolo F Perez, Murillo F Rodrigues, Chris CR Smith, Jeffrey P Spence, Anastasia Teterina, Silas Tittes, Per Unneberg, Juan Manuel Vazquez, Ryan K Waples, Anthony Wilder Wohns, Yan Wong, Franz Baumdicker, Reed A Cartwright, Gregor Gorjanc, Ryan N Gutenkunst, Jerome Kelleher, Andrew D Kern, Aaron P Ragsdale, Peter L Ralph, Daniel R Schrider, Ilan Gronau
Publikováno v:
eLife, Vol 12 (2023)
Simulation is a key tool in population genetics for both methods development and empirical research, but producing simulations that recapitulate the main features of genomic datasets remains a major obstacle. Today, more realistic simulations are pos
Externí odkaz:
https://doaj.org/article/ed75e3569fbf474782ef3b9546fe2394
Autor:
Montaser F Shaheen, Julie Y Tse, Ethan S Sokol, Margaret Masterson, Pranshu Bansal, Ian Rabinowitz, Christy A Tarleton, Andrey S Dobroff, Tracey L Smith, Thèrése J Bocklage, Brian K Mannakee, Ryan N Gutenkunst, Joyce Bischoff, Scott A Ness, Gregory M Riedlinger, Roman Groisberg, Renata Pasqualini, Shridar Ganesan, Wadih Arap
Publikováno v:
eLife, Vol 11 (2022)
Background: Lymphatic malformations (LMs) often pose treatment challenges due to a large size or a critical location that could lead to disfigurement, and there are no standardized treatment approaches for either refractory or unresectable cases. Met
Externí odkaz:
https://doaj.org/article/c6163aac82254054b261cfba4ae2852f
Autor:
Jeffrey R Adrion, Christopher B Cole, Noah Dukler, Jared G Galloway, Ariella L Gladstein, Graham Gower, Christopher C Kyriazis, Aaron P Ragsdale, Georgia Tsambos, Franz Baumdicker, Jedidiah Carlson, Reed A Cartwright, Arun Durvasula, Ilan Gronau, Bernard Y Kim, Patrick McKenzie, Philipp W Messer, Ekaterina Noskova, Diego Ortega-Del Vecchyo, Fernando Racimo, Travis J Struck, Simon Gravel, Ryan N Gutenkunst, Kirk E Lohmueller, Peter L Ralph, Daniel R Schrider, Adam Siepel, Jerome Kelleher, Andrew D Kern
Publikováno v:
eLife, Vol 9 (2020)
The explosion in population genomic data demands ever more complex modes of analysis, and increasingly, these analyses depend on sophisticated simulations. Recent advances in population genetic simulation have made it possible to simulate large and c
Externí odkaz:
https://doaj.org/article/3524c850e8cf4035a0c097b7202a542b
Autor:
Brian K Mannakee, Ryan N Gutenkunst
Publikováno v:
PLoS Genetics, Vol 12, Iss 7, p e1006132 (2016)
The long-held principle that functionally important proteins evolve slowly has recently been challenged by studies in mice and yeast showing that the severity of a protein knockout only weakly predicts that protein's rate of evolution. However, the r
Externí odkaz:
https://doaj.org/article/67f6ce4c28ba47dba9bd742d11c5e21b
Autor:
Ryan N Gutenkunst, Joshua J Waterfall, Fergal P Casey, Kevin S Brown, Christopher R Myers, James P Sethna
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 10, Pp 1871-1878 (2007)
Quantitative computational models play an increasingly important role in modern biology. Such models typically involve many free parameters, and assigning their values is often a substantial obstacle to model development. Directly measuring in vivo b
Externí odkaz:
https://doaj.org/article/7946c35be1c14192b260ae11c1c21d0f
Autor:
Alexandra Jilkine, Ryan N Gutenkunst
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 3, p e1003481 (2014)
Accumulating evidence suggests that many tumors have a hierarchical organization, with the bulk of the tumor composed of relatively differentiated short-lived progenitor cells that are maintained by a small population of undifferentiated long-lived c
Externí odkaz:
https://doaj.org/article/24c758b893494bc1adfaac3f3555f4bd
Autor:
Amber M Smith, Frederick R Adler, Ruy M Ribeiro, Ryan N Gutenkunst, Julie L McAuley, Jonathan A McCullers, Alan S Perelson
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003238 (2013)
Secondary bacterial infections are a leading cause of illness and death during epidemic and pandemic influenza. Experimental studies suggest a lethal synergism between influenza and certain bacteria, particularly Streptococcus pneumoniae, but the pre
Externí odkaz:
https://doaj.org/article/80bd0af2c13d47d994bd55b47d3c9a6a
Autor:
Xin Ma, Joanna L Kelley, Kirsten Eilertson, Shaila Musharoff, Jeremiah D Degenhardt, André L Martins, Tomas Vinar, Carolin Kosiol, Adam Siepel, Ryan N Gutenkunst, Carlos D Bustamante
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77175 (2013)
To gain insights into evolutionary forces that have shaped the history of Bornean and Sumatran populations of orang-utans, we compare patterns of variation across more than 11 million single nucleotide polymorphisms found by previous mitochondrial an
Externí odkaz:
https://doaj.org/article/7090b00f81ee43a8a09926ee1945932b
Autor:
Amber M Smith, Frederick R Adler, Julie L McAuley, Ryan N Gutenkunst, Ruy M Ribeiro, Jonathan A McCullers, Alan S Perelson
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 2, p e1001081 (2011)
Relatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication,
Externí odkaz:
https://doaj.org/article/4b22962761f448a1bf1fbadf1a1cf4b9
Autor:
Helena Skar, Ryan N Gutenkunst, Karin Wilbe Ramsay, Annette Alaeus, Jan Albert, Thomas Leitner
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e21747 (2011)
The molecular evolution of HIV-1 is characterized by frequent substitutions, indels and recombination events. In addition, a HIV-1 population may adapt through frequency changes of its variants. To reveal such population dynamics we analyzed HIV-1 su
Externí odkaz:
https://doaj.org/article/84aa7ac48de946049c1b8fb5ec7d845f