Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ryan M. Shepard"'
Autor:
Tomoyuki Koga, Jianfang Ning, Jun Ma, Anhua Wu, Clark C. Chen, Beibei Xu, Tao Jiang, Gan You, Megan M. Kaneda, Frank B. Furnari, Judith A. Varner, Kunal S. Patel, Ryan M. Shepard, Jeremy N. Rich, Sanjay Dhawan, Ming Li, Andrew S. Venteicher, Aaron L. Sarver, Jie Li, Hua Zhu, Christopher K. Glass
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 16
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Precision medicine in oncology leverages clinical observations of exceptional response. Toward an understanding of the molecular features that define this response, we applied an integrated, multiplatform analysis of RNA profiles derived from clinica
Publikováno v:
Cancer Immunology Research. 10:P076-P076
Integrin αvβ3, an epithelial-to-mesenchymal transition marker, promotes drug resistance and metastasis in a range of epithelial cancers. Hence, a humanized anti-αvβ3 antibody (Etaracizumab), developed in the 1990s, was designed to eliminate αvβ
Autor:
Paulina Pathria, Ryan M. Shepard, Judith A. Varner, Hideyuki Takahashi, Tiani L. Louis, Ann Shih
Publikováno v:
Cancer Immunology Research. 8:A86-A86
Introduction: Tumor-associated macrophages promote immunosuppressive microenvironment in head and neck squamous cell carcinoma (HNSCC). We previously reported that macrophage PI3-kinase γ (PI3Kγ) controls a critical switch between immune stimulatio
Autor:
Hideyuki Takahashi, Paulina Pathria, Ann Shih, Ryan M. Shepard, Marc A. Paradise, Judith A. Varner
Publikováno v:
Cancer Research. 79:1513-1513
We previously reported that macrophage PI3-kinase γ (PI3Kγ) controls a critical switch between immune stimulation and suppression during inflammation and cancer. PI3Kγ inhibition repolarizes tumor-associated macrophages, leading to downregulation
Autor:
Paulina Pathria, Hideyuki Takahashi, Megan Kaneda, Minya Pu, Karen Messer, Ryan M. Shepard, Tiani L. Louis, Ann Shih, Mark Bertagnolli, Wolfgang Wrasidlo, David A. Cheresh, Judith A. Varner
Publikováno v:
Cancer Research. 79:113-113
Macrophages play a key role in promoting tumor growth and resistance to therapy. Here we show that Tissue Resident Macrophages (TRM) as well as Bone Marrow-Derived Macrophages (BMDM) play critical but unique roles in promoting tumor growth. TRM were
Autor:
Minya Pu, David A. Cheresh, Ryan M. Shepard, Mark Bertagnolli, Paulina Pathria, Wolfgang Wrasidlo, Karen Messer, Judith A. Varner, Megan M. Kaneda, Tiani L. Louis, Hideyuki Takahashi, Ann Shih
Publikováno v:
Cancer Research. 78:5006-5006
Macrophages play a key role in promoting tumor growth and resistance to therapy. Here we show that tissue-resident as well as bone marrow-derived macrophages play critical roles in promoting tumor growth. Tissue-resident macrophages were recently sho