Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ryan M. Sheehy"'
Publikováno v:
Journal of Osteopathic Medicine. 122:187-194
Context National licensing exams (NLEs) including the Comprehensive Osteopathic Medical Licensing Examination (COMLEX) Level 1 evaluate student achievement. Scores have historically been utilized to stratify medical student applicants for residency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4207f0f2cdf060ee24da241ae2c1e3b6
https://doi.org/10.1515/jom-2021-0175
https://doi.org/10.1515/jom-2021-0175
RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth
Autor:
Jussara Hagen, Timothy Ginader, Abbey L. Perl, Terry A. Braun, Gideon K. D. Zamba, Bart J. Brown, Dawn E. Quelle, James R. Howe, Jacqueline A. Reilly, Goutham Narla, Benjamin W. Darbro, Fenghuang Zhan, Angela M. Schab, Aaron T. Scott, Blake L. Letney, Jordan L. Kohlmeyer, Courtney A. Kaemmer, Shaikamjad Umesalma, Joseph S. Dillon, David K. Meyerholz, Mariah R. Leidinger, Stefan Strack, Thomas M. O'Dorisio, Andrew M. Bellizzi, Agshin F. Taghiyev, Frederick W. Quelle, Nitija Tiwari, Ronald A. Merrill, Ryan M. Sheehy
Publikováno v:
Journal of Clinical Investigation. 129:1641-1653
Hyperactivated AKT/mTOR signaling is a hallmark of pancreatic neuroendocrine tumors (PNETs). Drugs targeting this pathway are used clinically, but tumor resistance invariably develops. A better understanding of factors regulating AKT/mTOR signaling a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232bebbf58142beac4d6bf84a1f8bff8
https://doi.org/10.1172/jci123049
https://doi.org/10.1172/jci123049
Autor:
Aloysius J. Klingelhutz, Kathleen R. Markan, Katarina Kulhankova, Dawn E. Quelle, Ryan M. Sheehy, Zhiyong Zhu, Zoya B. Kurago, Francoise A. Gourronc, Leonid V. Zingman, James A. Ankrum
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236741 (2020)
PLoS ONE
PLoS ONE
Aryl hydrocarbon receptor (AHR) agonists such as dioxin have been associated with obesity and the development of diabetes. Whole-body Ahr knockout mice on high-fat diet (HFD) have been shown to resist obesity and hepatic steatosis. Tissue-specific kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a221e2df261bb152021c09f9b21a4c
https://doaj.org/article/27c70c7efd0c42fbbb3d8d2fe307dec7
https://doaj.org/article/27c70c7efd0c42fbbb3d8d2fe307dec7
Publikováno v:
Cancer Biology & Therapy. 16:1259-1268
Schweinfurthins are intriguing natural products with anti-cancer activities and as yet incompletely understood mechanisms of action. We investigated whether inhibitors of P-glycoprotein (Pgp), in a manner analogous to other natural products, might en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2455f9a2f5e609c568ca8dfb3ec7f59c
https://doi.org/10.1080/15384047.2015.1056420
https://doi.org/10.1080/15384047.2015.1056420
Autor:
Dawn E. Quelle, Ryan M. Sheehy, James R. Howe, Nitija Tiwari, Scott K. Sherman, Benjamin W. Darbro, Thomas M. O'Dorisio, Andrew M. Bellizzi, Jackson Nteeba, Jussara Hagen, Shaik Amjad Ume Salma, Jacki Reilly
Publikováno v:
Cancer Research. 77:1368-1368
Introduction: A better molecular understanding of pancreatic neuroendocrine tumors (PNETs) is needed to improve patient diagnosis and treatment. Everolimus (mTOR inhibitor) is a standard-of-care therapy for PNET patients based on aberrant activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8240dea6c7efff43141df7d2a4cf8903
https://doi.org/10.1158/1538-7445.am2017-1368
https://doi.org/10.1158/1538-7445.am2017-1368
Publikováno v:
Cancer Research. 74:811-811
Schweinfurthins are intriguing natural product anti-cancer agents with incompletely defined mechanisms of action. Schweinfurthins increase ER stress and result in apoptosis in vitro. To augment schweinfurthins’ growth inhibitory activity we hypothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0389537d26d5530dd402d0aece0ec5ba
https://doi.org/10.1158/1538-7445.am2014-811
https://doi.org/10.1158/1538-7445.am2014-811
Publikováno v:
Molecular pharmacology. 82(1)
Schweinfurthins are potent inhibitors of cancer cell growth, especially against human central nervous system tumor lines such as SF-295 cells. However, the mechanisms through which these compounds impede cell growth are not fully understood. In an ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1ddd4bc2f56e546b01ce69f97edc2a
https://pubmed.ncbi.nlm.nih.gov/22461663
https://pubmed.ncbi.nlm.nih.gov/22461663
Publikováno v:
Journal of Osteopathic Medicine; Apr2022, Vol. 122 Issue 4, p187-194, 8p
Publikováno v:
Pancreas; Mar2022, Vol. 51 Issue 3, pe31-e59, 29p