Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ryan M. Pelis"'
Autor:
Aaron O. Buaben, Ryan M. Pelis
Publikováno v:
Journal of Xenobiotics, Vol 13, Iss 2, Pp 205-217 (2023)
Accurate predictions of drug uptake transporter involvement in renal excretion of xenobiotics require determination of in vitro transport kinetic parameters under initial-rate conditions. The purpose of the present study was to determine how changing
Externí odkaz:
https://doaj.org/article/1c4dd1fcaec047bb8652360939252eeb
Autor:
Muhammad Erfan Uddin, Eric D. Eisenmann, Yang Li, Kevin M. Huang, Dominique A. Garrison, Zahra Talebi, Alice A. Gibson, Yan Jin, Mahesh Nepal, Ingrid M. Bonilla, Qiang Fu, Xinxin Sun, Alec Millar, Mikhail Tarasov, Christopher E. Jay, Xiaoming Cui, Heidi J. Einolf, Ryan M. Pelis, Sakima A. Smith, Przemysław B. Radwański, Douglas H. Sweet, Jörg König, Martin F. Fromm, Cynthia A. Carnes, Shuiying Hu, Alex Sparreboom
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8607
Dofetilide is a rapid delayed rectifier potassium current inhibitor widely used to prevent the recurrence of atrial fibrillation and flutter. The clinical use of this drug is associated with increases in QTc interval, which predispose patients to ven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e3187d625b91e0b11b4e75f38bca4d
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Organic anion transporter 2 (OAT2) is likely important for renal and hepatic drug elimination. Three variants of the OAT2 peptide sequence have been described – OAT2 transcript variant 1 (OAT2-tv1), OAT2 transcript variant 2 (OAT2-tv2) and OAT2 tra
Externí odkaz:
https://doaj.org/article/94df76a6460843789a6f0cf3bed8e094
Publikováno v:
Clinical pharmacology and therapeutics. 107(5)
Understanding transporter-mediated drug disposition and pharmacokinetics (PK) in patients with nonalcoholic fatty liver disease (NAFLD) is critical in developing treatment options. Here, we quantified the expression levels of major drug transporters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8152aa0e79e8da042d9545d07cada34
https://pubmed.ncbi.nlm.nih.gov/31630405
https://pubmed.ncbi.nlm.nih.gov/31630405
Autor:
Ryan M. Pelis, Jonghwa Lee
Publikováno v:
Drug Metabolism and Disposition. 44:1675-1681
The ocular barriers (cornea, blood-retinal barrier, and blood-aqueous humor barrier) make treating eye diseases with therapeutic drugs challenging. The tight capillary endothelium of the iris and the ciliary body epithelium form the blood-aqueous hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d898e3477feeb1650b5f21df57ecc000
https://doi.org/10.1124/dmd.116.069369
https://doi.org/10.1124/dmd.116.069369
Autor:
Leslie Ingraham, Ryan M. Pelis, Adam Hotchkiss, Man-Song Li, Usman Khan, Liam Berrigan, Tiandai Gao
Publikováno v:
Drug Metabolism and Disposition. 43:1847-1854
The mechanism by which drugs inhibit organic anion transporter 1 (OAT1) was examined. OAT1 was stably expressed in Chinese hamster ovary (CHO) cells, and para-aminohippurate (PAH) and 6-carboxyfluorescein were the substrates. Most compounds (10 of 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e780420fa9cb966d867ae5331ee108
https://doi.org/10.1124/dmd.115.065748
https://doi.org/10.1124/dmd.115.065748
Autor:
Miguel Coca-Prados, Nicholas A. Delamere, Jonghwa Lee, Mohammad Shahidullah, Adam Hotchkiss, Ryan M. Pelis
Publikováno v:
Molecular Pharmacology. 87:697-705
The purpose of this study was to determine the direction of organic anion (OA) transport across the ciliary body and the transport proteins that may contribute. Transport of several OAs across the bovine ciliary body was examined using ciliary body s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52bc4c7b2cacc8735937600eea2a294b
https://doi.org/10.1124/mol.114.096578
https://doi.org/10.1124/mol.114.096578
Publikováno v:
Frontiers in Pharmacology
The discovery of ClC proteins at the beginning of the 1990s was important for the development of the Cl- transport research field. ClCs form a large family of proteins that mediate voltage-dependent transport of Cl- ions across cell membranes. They a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e307ff5cfd8ce9074ebab304ba7836
https://doi.org/10.3389/fphar.2017.00151
https://doi.org/10.3389/fphar.2017.00151
Autor:
Elizabeth McCandlish, Xia Wen, Michael Goedken, Lauren M. Aleksunes, Brian Buckley, José E. Manautou, Samira Syed, Ryan M. Pelis
Publikováno v:
The American Journal of Pathology. 184(5):1299-1308
The chemotherapeutic drug cisplatin is actively transported into proximal tubules, leading to acute renal injury. Previous studies suggest that the multidrug resistance–associated protein 2 (Mrp2) transporter may efflux cisplatin conjugates from ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041b68a02d71f14ea39174b44b0cbf0a
Autor:
J. Larry Renfro, Mansong Li, Sonda L. Parker, Arpine Vapurcuyan, Ryan M. Pelis, Leslie Ingraham, Imad Hanna
Publikováno v:
Molecular Pharmacology. 86:86-95
The purpose of the present study was to determine whether a physiologic plasma concentration of α-ketoglutarate (αKG) influences the kinetic interaction of ligands with organic anion transporter 1 (OAT1). The effect of extracellular αKG on the kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bc6d3c81d2c9f229e7d19b1b5ee2c4
https://doi.org/10.1124/mol.114.091777
https://doi.org/10.1124/mol.114.091777