Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Ryan M. Laddusaw"'
1
Structure of pyrazole derivatives impact their affinity, stoichiometry, and cooperative interactions for CYP2E1 complexes
Autor: Grover P. Miller, Martin D. Perry, Ryan M. Laddusaw, Amber Bradley, Jessica H. Hartman
Publikováno v: Archives of Biochemistry and Biophysics. 537:12-20
CYP2E1 plays a critical role in detoxification and carcinogenic activation of drugs, pollutants, and dietary compounds; however, these metabolic processes can involve poorly characterized cooperative interactions that compromise the ability to unders
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4befcd98c79586a64aac3eb539fce20
https://doi.org/10.1016/j.abb.2013.06.011
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2
Dibridgehead Diphosphines that Turn Themselves Inside Out
Autor: Nattamai Bhuvanesh, Michael Stollenz, Tobias Fiedler, Agnieszka J. Nawara-Hultzsch, Michał Barbasiewicz, John A. Gladysz, Ryan M. Laddusaw
Publikováno v: Angewandte Chemie International Edition. 50:6647-6651
Molecules and macromolecules that undergo topologically complex dynamic processes—such as knot-forming and multistep folding sequences—have attracted considerable attention from numerous standpoints. However, there is much less awareness that cer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b20256272f64ae41e20aa62330d36da
https://doi.org/10.1002/anie.201100893
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4
CYP2E1 Substrate Inhibition
Autor: Amber M. Burch, Petr Kuzmic, Samuel L. Collom, Martin D. Perry, Grover P. Miller, Ryan M. Laddusaw
Publikováno v: Journal of Biological Chemistry. 283:3487-3496
In this study we offer a mechanistic interpretation of the previously known but unexplained substrate inhibition observed for CYP2E1. At low substrate concentrations, p-nitrophenol (pNP) was rapidly turned over (47 min(-1)) with relatively low K(m) (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75d0e31d19ce111608643a8bf7cddc0f
https://doi.org/10.1074/jbc.m707630200
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5
CYP2E1 substrate inhibition. Mechanistic interpretation through an effector site for monocyclic compounds
Autor: Samuel L, Collom, Ryan M, Laddusaw, Amber M, Burch, Petr, Kuzmic, Martin D, Perry, Grover P, Miller
Publikováno v: The Journal of biological chemistry. 283(6)
In this study we offer a mechanistic interpretation of the previously known but unexplained substrate inhibition observed for CYP2E1. At low substrate concentrations, p-nitrophenol (pNP) was rapidly turned over (47 min(-1)) with relatively low K(m) (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d24f00b6bbab17dd47664b31da61ac2
https://pubmed.ncbi.nlm.nih.gov/18056994
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