Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ryan M. Hemsley"'
Autor:
Jeffrey A. Banas, Erika Takanami, Ryan M. Hemsley, Alissa Villhauer, Min Zhu, Fang Qian, Amber Marolf, David R. Drake
Publikováno v:
Journal of Oral Microbiology, Vol 12, Iss 1 (2020)
Background: Dental caries etiology is attributed to a dysbiotic imbalance within the plaque microbiome leading to a dominance of strong acidogens. Some studies that investigate the link between acidogens and caries quantify the recovery of acid toler
Externí odkaz:
https://doaj.org/article/ad071b86bc524881b7673d90c8ab16ca
Autor:
Monica Cal, Paul H. Davis, Sergio Wittlin, Marcel Kaiser, Elyssa B Darner, Jonathan L. Vennerstrom, Ryan M. Hemsley, Jianbo Wu, LeeAnna M. Lui, Derek A. Leas, Austin G. Sanford
Publikováno v:
ACS Infect Dis
We now describe the physicochemical profiling, in vitro ADME, and antiparasitic activity of eight N,N′-diarylureas to assess their potential as a broad-spectrum antiprotozoal chemotype. Chromatographic LogD(7.4) values ranged from 2.5 to 4.5; kinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd56129268d2383b010db8460d12fc0
https://doi.org/10.1021/acsinfecdis.1c00135
https://doi.org/10.1021/acsinfecdis.1c00135
Autor:
Gong Chen, Ryan M. Hemsley, Jianbo Wu, Karen L. White, Jennifer Keiser, David M. Shackleford, Chunkai Wang, Austin G. Sanford, Derek A. Leas, Mireille Vargas, Paul H. Davis, Yuxiang Dong, Jonathan L. Vennerstrom, Susan A. Charman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:244-248
N,N′-Diaryl ureas have recently emerged as a new antischistosomal chemotype. We now describe physicochemical profiling, in vitro ADME, plasma exposure, and ex vivo and in vivo activities against Schistosoma mansoni for twenty new N,N′-diaryl urea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0f6bcfcfc5a2e2accec9ca9aed1b1e
https://doi.org/10.1016/j.bmcl.2017.12.064
https://doi.org/10.1016/j.bmcl.2017.12.064
Autor:
Austin G. Sanford, Paul H. Davis, Lakshmi-Prasad Potluri, Ryan M. Hemsley, Sydney J. Zach, Joshua J. Larson, Thomas T. Schulze, Abigail K. Judge, Jonathan L. Vennerstrom, Xiaofang Wang, Susan A. Charman
Publikováno v:
Parasitology international. 67(2)
We profiled three novel T. gondii inhibitors identified from an antimalarial phenotypic high throughput screen (HTS) campaign: styryl 4-oxo-1,3-benzoxazin-4-one KG3, tetrahydrobenzo[b]pyran KG7, and benzoquinone hydrazone KG8. These compounds inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5cbb44de25ada949a325aa7262a1bc
https://pubmed.ncbi.nlm.nih.gov/29081387
https://pubmed.ncbi.nlm.nih.gov/29081387
Autor:
Jeffrey A. Banas, Min Zhu, Erika Takanami, Alissa L. Villhauer, Amber Marolf, David R. Drake, Fang Qian, Ryan M. Hemsley
Publikováno v:
Journal of Oral Microbiology
Journal of Oral Microbiology, Vol 12, Iss 1 (2020)
Journal of Oral Microbiology, Vol 12, Iss 1 (2020)
Background: Dental caries etiology is attributed to a dysbiotic imbalance within the plaque microbiome leading to a dominance of strong acidogens. Some studies that investigate the link between acidogens and caries quantify the recovery of acid toler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b95149a2b3886bc857c7fc3fe591a65
https://doi.org/10.1080/20002297.2019.1688449
https://doi.org/10.1080/20002297.2019.1688449