Výsledky vyhledávání - "Ryan M. Gillihan"

Different mechanisms for resistance to trastuzumab versus lapatinib in her2- positive breast cancers - role of estrogen receptor and her2 reactivation

Autor: Gladys Morrison, Rachel Schiff, Yen-Chao Wang, C. Kent Osborne, Ryan M. Gillihan, Xiaoyong Fu, Maria F. Botero, N.A. Healy, Jun Guo, Robin Ward, Mothaffar F. Rimawi, Gail Lewis Phillips, Susan G. Hilsenbeck, Gary C. Chamness

Publikováno v: Breast Cancer Research : BCR

Introduction: The human epidermal growth factor receptor 2 (HER2)-targeted therapies trastuzumab (T) and lapatinib (L) show high efficacy in patients with HER2-positive breast cancer, but resistance is prevalent. Here we investigate resistance mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61851283188505931fc13368b1363559
http://hdl.handle.net/10379/14378

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Abstract 2290: Crosstalk between ER and PI3K signaling pathways in human luminal type breast cancer and its therapeutic implications

Autor: Martin Shea, Ryan M. Gillihan, Chad J. Creighton, Adrian V. Lee, Rachel Schiff, Kent Osborne, Susan G. Hilsenbeck, Xiaoyong Fu, Sarmistha Nanda

Publikováno v: Cancer Research. 71:2290-2290

Background: We have recently shown that the luminal B subtype breast cancer (BC) is associated with PI3K molecular signature. Breast tumors of the luminal B subtype generally have lower ER expression levels and/or activity and are more aggressive and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58ad5ff33eef885b3c23587354b951b3
https://doi.org/10.1158/1538-7445.am2011-2290

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