Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ryan M. Boomer"'
Autor:
Markus Kurz, Charles Wilson, Scott D. Lewis, Kristin Thompson, Judith M. Healy, Thomas Green Mccauley, Ryan M. Boomer
Publikováno v:
Pharmaceutical Research. 21:2234-2246
Aptamers are highly selective nucleic acid-based drugs that are currently being developed for numerous therapeutic indications. Here, we determine plasma pharmacokinetics and tissue distribution in rat of several novel aptamer compositions, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285755f5b29454ab803a34287b1bb985
https://doi.org/10.1007/s11095-004-7676-4
https://doi.org/10.1007/s11095-004-7676-4
Autor:
Jeffrey Kurz, Sara Chesworth Keene, John L. Diener, Ryan M. Boomer, Jayaram Srinivasan, Charles Wilson, David Epstein, Markus Kurz, Jill Blanchard, Nobuko Hamaguchi, Sharon T. Cload
Publikováno v:
Chemistry & Biology. 11(4):499-508
Two molecular sensors that specifically recognize ADP in a background of over 100-fold molar excess of ATP are described. These sensors are nucleic-acid based and comprise a general method for monitoring protein kinase activity. The ADP-aptamer scint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6b17205ce2856e3f472a40b63c0777
Autor:
John L. Diener, Sharon T. Cload, Markus Kurz, Anthony D. Keefe, Sara Chesworth Keene, Ryan M. Boomer, Charles Wilson, Alicia Ferguson
Publikováno v:
Nucleic Acids Research. 32:1756-1766
We have utilized in vitro selection technology to develop allosteric ribozyme sensors that are specific for the small molecule analytes caffeine or aspartame. Caffeine- or aspartame-responsive ribozymes were converted into fluorescence-based RiboRepo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc38a281fded66c3f53f155a83d914c5
https://doi.org/10.1093/nar/gkh336
https://doi.org/10.1093/nar/gkh336
Autor:
Birgit Schultes, Seth Ettenberg, Shyra Gardai, Lori Westendorf, Katie O'Callaghan, Heather Huet, Ryan M. Boomer, Taylor Hickman, Django Sussman, Allison Nelson, Luke Manlove, Kathleen E. McGinness, Tooba A. Cheema
Publikováno v:
Cancer Research. 77:4605-4605
B cell maturation antigen (BCMA) has recently emerged as an attractive therapeutic target in multiple myeloma. BCMA has restricted expression on plasma cells with little to no expression on other normal tissues, but is upregulated on the surface of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5b967a976b2949823a1f347bdcc099c
https://doi.org/10.1158/1538-7445.am2017-4605
https://doi.org/10.1158/1538-7445.am2017-4605
Autor:
Birgit Schultes, R. Anthony Barnitz, Kathleen R. Whiteman, Lan Cao, Seth Ettenberg, John Shin, Tooba Cheema, Casey Judge, Ann Ranger, Geoffrey Hodge, Michael J. Vasconcelles, Kathleen E. McGinness, Ryan M. Boomer, Heather Huet
Publikováno v:
Blood. 128:3512-3512
The Antibody-Coupled T-cell Receptor (ACTR) platform is a universal engineered T cell therapy developed to mediate anti-tumor activity in combination with tumor-targeting antibodies. The ACTR construct is composed of the extracellular domain of CD16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::786645f9403cca1900b996f565614c12
https://doi.org/10.1182/blood.v128.22.3512.3512
https://doi.org/10.1182/blood.v128.22.3512.3512
Autor:
Ryan M. Boomer, Markus Kurz, Scott D. Lewis, Thomas Green Mccauley, Charles Wilson, Judith M. Healy
Publikováno v:
Oligonucleotides. 15(3)
Here, we examine biodistribution of radiolabeled aptamers and assess the relative ability of different stabilized aptamer compositions (mixed 2'-F/2'-O-Me; fully 2'-O-Me modified) to access inflamed tissues in a murine inflammation model. Biodistribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4706219149c3844706803f843b5ed11
https://pubmed.ncbi.nlm.nih.gov/16201906
https://pubmed.ncbi.nlm.nih.gov/16201906
Autor:
Scott D. Lewis, Joseph M. Fraone, Ankit Makim, John L. Diener, David Fontana, H. Nicholas Marsh, H. A. Daniel Lagasse, Claude R. Benedict, James Rottman, Ryan M. Boomer, Renta Hutabarat, Jason R. Killough, Larry Cai, Madaline Gilbert, Patricia G. Merlino, Thomas Green Mccauley
Publikováno v:
Blood. 108:3930-3930
Following coronary artery damage, von Willebrand Factor (vWF) multimers adhere to exposed collagen via the vWF A3 domain. Platelets passing through damaged vessels under the conditions of high shear force associated with stenosed arteries will adhere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1098b2b7e76bbb5776e1198f1e26a411
https://doi.org/10.1182/blood.v108.11.3930.3930
https://doi.org/10.1182/blood.v108.11.3930.3930
Autor:
Ryan M. Boomer, Scott D. Lewis, Judith M. Healy, Markus Kurz, Charles Wilson, Thomas G. McCauley
Publikováno v:
Oligonucleotides; Fall2005, Vol. 15 Issue 3, p183-195, 13p