Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ryan M. Baxley"'
Autor:
Megan M. Schmit, Ryan M. Baxley, Liangjun Wang, Peter Hinderlie, Marissa Kaufman, Emily Simon, Anjali Raju, Jeffrey S. Miller, Anja-Katrin Bielinsky
Publikováno v:
Open Biology, Vol 14, Iss 1 (2024)
Natural killer (NK) cell deficiency (NKD) is a rare disease in which NK cell function is reduced, leaving affected individuals susceptible to repeated viral infections and cancer. Recently, a patient with NKD was identified carrying compound heterozy
Externí odkaz:
https://doaj.org/article/0db20a9d684b4d8e8109368dc50efee5
Autor:
Wendy Leung, Ryan M. Baxley, Emma Traband, Ya-Chu Chang, Colette B. Rogers, Liangjun Wang, Wesley Durrett, Kendall S. Bromley, Lidia Fiedorowicz, Tanay Thakar, Anika Tella, Alexandra Sobeck, Eric A. Hendrickson, George-Lucian Moldovan, Naoko Shima, Anja-Katrin Bielinsky
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113523- (2023)
Summary: Ubiquitination of proliferating cell nuclear antigen (PCNA) at lysine 164 (K164) activates DNA damage tolerance pathways. Currently, we lack a comprehensive understanding of how PCNA K164 ubiquitination promotes genome stability. To evaluate
Externí odkaz:
https://doaj.org/article/0ee3d1a6203142ac8d65a9bb37a15e23
Autor:
Laura J. Grange, John J. Reynolds, Farid Ullah, Bertrand Isidor, Robert F. Shearer, Xenia Latypova, Ryan M. Baxley, Antony W. Oliver, Anil Ganesh, Sophie L. Cooke, Satpal S. Jhujh, Gavin S. McNee, Robert Hollingworth, Martin R. Higgs, Toyoaki Natsume, Tahir Khan, Gabriel Á. Martos-Moreno, Sharon Chupp, Christopher G. Mathew, David Parry, Michael A. Simpson, Nahid Nahavandi, Zafer Yüksel, Mojgan Drasdo, Anja Kron, Petra Vogt, Annemarie Jonasson, Saad Ahmed Seth, Claudia Gonzaga-Jauregui, Karlla W. Brigatti, Alexander P. A. Stegmann, Masato Kanemaki, Dragana Josifova, Yuri Uchiyama, Yukiko Oh, Akira Morimoto, Hitoshi Osaka, Zineb Ammous, Jesús Argente, Naomichi Matsumoto, Constance T.R.M. Stumpel, Alexander M. R. Taylor, Andrew P. Jackson, Anja-Katrin Bielinsky, Niels Mailand, Cedric Le Caignec, Erica E. Davis, Grant S. Stewart
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
The SMC5/6 complex is critical for genome stability. Here, the authors identify mutations in SLF2 and SMC5 as cause of Atelís Syndrome characterized by microcephaly, short stature, anemia, segmented chromosomes and mosaic variegated hyperploidy.
Externí odkaz:
https://doaj.org/article/bfe3845b80824c5996d10d21e1575e9d
Autor:
Ya-Chu Chang, Kevin Lin, Ryan M. Baxley, Wesley Durrett, Liangjun Wang, Olivera Stojkova, Maximilian Billmann, Henry Ward, Chad L. Myers, Anja-Katrin Bielinsky
Publikováno v:
Open Biology, Vol 13, Iss 8 (2023)
DNA replication requires precise regulation achieved through post-translational modifications, including ubiquitination and SUMOylation. These modifications are linked by the SUMO-targeted E3 ubiquitin ligases (STUbLs). Ring finger protein 4 (RNF4),
Externí odkaz:
https://doaj.org/article/fc25571c38be441b9df006b8d49f3bfe
Autor:
Ryan M. Baxley, Wendy Leung, Megan M. Schmit, Jacob Peter Matson, Lulu Yin, Marissa K. Oram, Liangjun Wang, John Taylor, Jack Hedberg, Colette B. Rogers, Adam J. Harvey, Debashree Basu, Jenny C. Taylor, Alistair T. Pagnamenta, Helene Dreau, Jude Craft, Elizabeth Ormondroyd, Hugh Watkins, Eric A. Hendrickson, Emily M. Mace, Jordan S. Orange, Hideki Aihara, Grant S. Stewart, Edward Blair, Jeanette Gowen Cook, Anja-Katrin Bielinsky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Minichromosome maintenance protein 10 (MCM10) is critical for eukaryotic DNA replication. Here, by modelling MCM10 variants in human cell lines, the authors reveal a mechanism of MCM10-associated disease, finding that loss of MCM10 function constrain
Externí odkaz:
https://doaj.org/article/fcda6dd35e9949f888622bfe0a813011
Autor:
Carolyn N. Paulson, Kristen John, Ryan M. Baxley, Fredy Kurniawan, Kayo Orellana, Rawle Francis, Alexandra Sobeck, Brandt F. Eichman, Walter J. Chazin, Hideki Aihara, Gunda I. Georg, Jon E. Hawkinson, Anja-Katrin Bielinsky
Publikováno v:
Open Biology, Vol 9, Iss 8 (2019)
Minichromosome maintenance protein 10 (Mcm10) is essential for DNA unwinding by the replisome during S phase. It is emerging as a promising anti-cancer target as MCM10 expression correlates with tumour progression and poor clinical outcomes. Here we
Externí odkaz:
https://doaj.org/article/5150118e038e43728fa377af3bba1099
Autor:
Jacob Peter Matson, Raluca Dumitru, Philip Coryell, Ryan M Baxley, Weili Chen, Kirk Twaroski, Beau R Webber, Jakub Tolar, Anja-Katrin Bielinsky, Jeremy E Purvis, Jeanette Gowen Cook
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/844643d2b8ab4da188065e16a30c8b92
Autor:
Jacob Peter Matson, Raluca Dumitru, Philip Coryell, Ryan M Baxley, Weili Chen, Kirk Twaroski, Beau R Webber, Jakub Tolar, Anja-Katrin Bielinsky, Jeremy E Purvis, Jeanette Gowen Cook
Publikováno v:
eLife, Vol 6 (2017)
Complete and robust human genome duplication requires loading minichromosome maintenance (MCM) helicase complexes at many DNA replication origins, an essential process termed origin licensing. Licensing is restricted to G1 phase of the cell cycle, bu
Externí odkaz:
https://doaj.org/article/6189178fb0c5476f957396fdb2db480c
Autor:
Caiyong Ye, Anja Katrin Bielinsky, Bing Xia, Zhihua Kang, Yamei Zuo, Pan Fu, Mirit I. Aladjem, Ryan M. Baxley, Christophe E. Redon, Lee Zou, Advaitha Madireddy, Zhiyuan Shen, Rémi Buisson, Tzeh Keong Foo, Haiqing Fu, Allen L. Alcivar
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
The BRCA2 tumor suppressor protects genome integrity by promoting homologous recombination-based repair of DNA breaks, stability of stalled DNA replication forks and DNA damage-induced cell cycle checkpoints. BRCA2 deficient cells display the radio-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cf269e58860fb67e6569b333099490
https://escholarship.org/uc/item/5s91p0w3
https://escholarship.org/uc/item/5s91p0w3
Autor:
Adam J. Harvey, Lulu Yin, Jacob Peter Matson, Jack Hedberg, Debashree Basu, John Taylor, Megan Schmit, Liangjun Wang, Jenny C. Taylor, Elizabeth Ormondroyd, Jordan S. Orange, Hideki Aihara, Edward Blair, Colette B. Rogers, Eric A. Hendrickson, Jeanette Gowen Cook, Ryan M. Baxley, Emily M. Mace, Alistair T. Pagnamenta, Anja Katrin Bielinsky, Wendy Leung, Hugh Watkins, Helene Dreau, Jude Craft, Marissa K. Oram, Grant S. Stewart
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Minichromosome maintenance protein 10 (MCM10) is essential for eukaryotic DNA replication. Here, we describe compound heterozygous MCM10 variants in patients with distinctive, but overlapping, clinical phenotypes: natural killer (NK) cell deficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c892fb3cd5e6fd2562c7cef29c0b5672
https://doi.org/10.1038/s41467-021-21878-x
https://doi.org/10.1038/s41467-021-21878-x