Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Ryan M. Ames"'
Autor:
Craig R. G. Willis, Colleen S. Deane, Ryan M. Ames, Joseph J. Bass, Daniel J. Wilkinson, Kenneth Smith, Bethan E. Phillips, Nathaniel J. Szewczyk, Philip J. Atherton, Timothy Etheridge
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Eccentric (ECC) and concentric (CON) contractions induce distinct muscle remodelling patterns that manifest early during exercise training, the causes of which remain unclear. We examined molecular signatures of early contraction mode-specif
Externí odkaz:
https://doaj.org/article/fe0c75ea1c924a239e9c9b0a609be2ea
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Background Beta cell identity changes occur in the islets of donors with diabetes, but the molecular basis of this remains unclear. Protecting residual functional beta cells from cell identity changes may be beneficial for patients with diab
Externí odkaz:
https://doaj.org/article/cf3290657dfa4fb7a48a41855ea1f38b
Autor:
Colleen S. Deane, Craig R.G. Willis, Bethan E. Phillips, Philip J. Atherton, Lorna W. Harries, Ryan M. Ames, Nathaniel J. Szewczyk, Timothy Etheridge
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 3, Pp 629-645 (2021)
Abstract Background Skeletal muscle atrophy manifests across numerous diseases; however, the extent of similarities/differences in causal mechanisms between atrophying conditions in unclear. Ageing and disuse represent two of the most prevalent and c
Externí odkaz:
https://doaj.org/article/fd572a80d98941e9ad93f5815f2f4413
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract Background Circular RNAs are non-coding RNA molecules with gene regulatory potential that have been associated with several human diseases. They are stable and present in the circulation, making them excellent candidates for biomarkers of di
Externí odkaz:
https://doaj.org/article/f89e031b6ea0432bb9ce66828fe1998b
Autor:
Katja Schaefer, Jeanette Wagener, Ryan M. Ames, Stella Christou, Donna M. MacCallum, Steven Bates, Neil A. R. Gow
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Amino acid metabolism is crucial for fungal growth and development. Ureohydrolases produce amines when acting on l-arginine, agmatine, and guanidinobutyrate (GB), and these enzymes generate ornithine (by arginase), putrescine (by agmatinase)
Externí odkaz:
https://doaj.org/article/a25cee59556847d1a07e1213bea9ad88
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Candida albicans is a normal member of the human microbiome. It is also an opportunistic pathogen, which can cause life-threatening systemic infections in severely immunocompromized individuals. Despite the availability of antifungal drugs, mortality
Externí odkaz:
https://doaj.org/article/38d1292dda88443ea9c94b8829d541f8
Autor:
Ryan M. Ames
Publikováno v:
Microorganisms, Vol 5, Iss 1, p 3 (2017)
Magnaporthe oryzae is the causal agent of rice blast disease, the most important infection of rice worldwide. Half the world’s population depends on rice for its primary caloric intake and, as such, rice blast poses a serious threat to food securit
Externí odkaz:
https://doaj.org/article/1132f26c302148e1be0f8ec4a85a5756
Autor:
Ryan M. Ames, Akshay Bhinge, Seema C. Namboori, Patricia Thomas, Lawrence W. Stanton, Alessandro Rosa, Lawrence O. Garrett, Craig R. G. Willis, Sophie Hawkins
Publikováno v:
Stem Cell Reports
Summary Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by the loss of motor neurons. We utilized single-cell transcriptomics to uncover dysfunctional pathways in degenerating motor neurons differentiated from
Autor:
Timothy Etheridge, Nathaniel J. Szewczyk, Lorna W. Harries, Colleen S. Deane, Bethan E. Phillips, Craig R. G. Willis, Ryan M. Ames, Philip J. Atherton
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 3, Pp 629-645 (2021)
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 3, Pp 629-645 (2021)
Background Skeletal muscle atrophy manifests across numerous diseases; however, the extent of similarities/differences in causal mechanisms between atrophying conditions in unclear. Ageing and disuse represent two of the most prevalent and costly atr
Autor:
Lorna W. Harries, Luanne L. Peters, Luigi Ferrucci, Shahnaz Haque, Stefania Bandinelli, Karen Moore, Luke C. Pilling, Ryan M. Ames
Publikováno v:
GeroScience
Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite the observation that circRNAs are known to accumulate in older organisms and have been reported in cell