Výsledky vyhledávání - "Ryan M. Alam"

Akademický článek

Regioselective N-alkylation of the 1H-indazole scaffold; ring substituent and N-alkylating reagent effects on regioisomeric distribution

Autor: Ryan M. Alam, John J. Keating

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1939-1951 (2021)

The indazole scaffold represents a promising pharmacophore, commonly incorporated in a variety of therapeutic drugs. Although indazole-containing drugs are frequently marketed as the corresponding N-alkyl 1H- or 2H-indazole derivative, the efficient

Externí odkaz: https://doaj.org/article/d59c408b83b84753bae26d03ed18e212

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An Expedient Approach to Pyrazolo[3,4-b]pyridine-3-carboxamides via Palladium-Catalyzed Aminocarbonylation

Autor: Ryan M. Alam, John J. Keating

Publikováno v: Synthesis. 53:4709-4722

Pyrazolo[3,4-b]pyridine is a privileged scaffold found in many small drug molecules that possess a wide range of pharmacological properties. Efforts to further develop and exploit synthetic methodologies that permit the functionalization of this hete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2cfa13543d9b5404d6c5e2f039b5aaf
https://doi.org/10.1055/s-0037-1610783

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Regioselective N-alkylation of the 1H-indazole scaffold; ring substituent and N-alkylating reagent effects on regioisomeric distribution

Autor: John J. Keating, Ryan M. Alam

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1939-1951 (2021)
Beilstein Journal of Organic Chemistry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41207cdc9be35cfda25e88769aaa398
https://doaj.org/article/d59c408b83b84753bae26d03ed18e212

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'Walking the nitrogen around the ring': Chemical synthesis and spectroscopic characterization of novel 4-, 5-, 6-, and 7-azaindazole analogs of the synthetic cannabinoid receptor agonist MDMB-PINACA

Autor: John J. Keating, Ryan M. Alam

Publikováno v: Drug testing and analysisREFERENCES. 14(2)

Over the past decade, synthetic cannabinoid receptor agonists (SCRAs) have rapidly evolved to encompass a wide range of structurally diverse new psychoactive substances (NPS), including derivatives that incorporate indole, indazole, 7-azaindole, γ-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d199c5a597beb32c590d5c85709ffa0a
https://pubmed.ncbi.nlm.nih.gov/34654062

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Adding more 'spice' to the pot: A review of the chemistry and pharmacology of newly emerging heterocyclic synthetic cannabinoid receptor agonists

Autor: John J. Keating, Ryan M. Alam

Publikováno v: Drug testing and analysisREFERENCES. 12(3)

Synthetic cannabinoid receptor agonists (SCRAs) first appeared on the international recreational drug market in the early 2000s in the form of SCRA-containing herbal blends. Due to the cannabimimetic effects associated with the consumption of SCRAs,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ab71d63d0e7cc37efcdd0011056a6e
https://pubmed.ncbi.nlm.nih.gov/31854124

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Sustained-release multiparticulates for oral delivery of a novel peptidic ghrelin agonist: Formulation design and in vitro characterization

Autor: Kenneth P. Howick, Brendan T. Griffin, John F. Cryan, Dalia Kandil, Harriët Schellekens, Aoife M. Ryan, Ryan M. Alam, Dara Fitzpatrick, Barbara Chruscicka

There is an impetus to provide appropriate sustained release oral delivery vehicles to protect biofunctional peptide loads from gastric degradation in vivo. This study describes the generation of a high load capacity pellet formulation for sustained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458bc42074ab630b79e8520a7b9af507
https://hdl.handle.net/10468/5092

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