Smooth muscle cells affect differential nanoparticle accumulation in disturbed blood flow-induced murine atherosclerosis.

Autor: Hunter A Miller, Morgan A Schake, Badrul Alam Bony, Evan T Curtis, Connor C Gee, Ian S McCue, Thomas J Ripperda, Yiannis S Chatzizisis, Forrest M Kievit, Ryan M Pedrigi

Publikováno v: PLoS ONE, Vol 16, Iss 12, p e0260606 (2021)

Atherosclerosis is a lipid-driven chronic inflammatory disease that leads to the formation of plaques in the inner lining of arteries. Plaques form over a range of phenotypes, the most severe of which is vulnerable to rupture and causes most of the c

Externí odkaz: https://doaj.org/article/293c101b920d4df4a2e3d9c2c593433d

Restoration of normal blood flow in atherosclerotic arteries promotes plaque stabilization

Autor: Morgan A. Schake, Ian S. McCue, Evan T. Curtis, Thomas J. Ripperda, Samuel Harvey, Bryan T. Hackfort, Anna Fitzwater, Yiannis S. Chatzizisis, Forrest M. Kievit, Ryan M. Pedrigi

Publikováno v: iScience. 26:106760

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5be6548d78c7ca7cfc0e075154466ac
https://doi.org/10.1016/j.isci.2023.106760

Influence of shear stress magnitude and direction on atherosclerotic plaque composition

Autor: Ryan M. Pedrigi, Vikram V. Mehta, Sandra M. Bovens, Zahra Mohri, Christian Bo Poulsen, Willy Gsell, Jordi L. Tremoleda, Leila Towhidi, Ranil de Silva, Enrico Petretto, Rob Krams

Publikováno v: Royal Society Open Science, Vol 3, Iss 10 (2016)

The precise flow characteristics that promote different atherosclerotic plaque types remain unclear. We previously developed a blood flow-modifying cuff for ApoE−/− mice that induces the development of advanced plaques with vulnerable and stable

Externí odkaz: https://doaj.org/article/76fe35acac5d4fd48f6f80f7901a76a6

Accommodation of the human lens capsule using a finite element model based on nonlinear regionally anisotropic biomembranes

Autor: Ryan M. Pedrigi, Guido David, Jay D. Humphrey

Publikováno v: Computer Methods in Biomechanics and Biomedical Engineering. 20:302-307

Accommodation of the eyes, the mechanism that allows humans to focus their vision on near objects, naturally diminishes with age via presbyopia. People who have undergone cataract surgery, using current surgical methods and artificial lens implants,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c37030ece6df295433e2d9c98e999b
https://doi.org/10.1080/10255842.2016.1228907

Plaque burden influences accurate classification of fibrous cap atheroma by in vivo optical coherence tomography in a porcine model of advanced coronary atherosclerosis

Autor: Jacob F. Bentzon, Hans Erik Bøtker, Ranil de Silva, Rob Krams, Christian Bo Poulsen, Niels Ramsing Holm, Erling Falk, Ismail Dogu Kilic, Nilesh Pareek, Ryan M. Pedrigi

Publikováno v: Poulsen, C B, Pedrigi, R M, Pareek, N, Kilic, I D, Holm, N R, Bentzon, J F, Bøtker, H E, Falk, E, Krams, R & de Silva, R 2018, ' Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis ', EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, vol. 14, no. 10 . https://doi.org/10.4244/EIJ-D-17-01028

Aims: In vivo validation of coronary optical coherence tomography (OCT) against histology and the effects of plaque burden (PB) on plaque classification remain unreported. We aimed to investigate this in a porcine model with human-like coronary ather

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669f74f74160084b82ef2c727cd2451e
https://pubmed.ncbi.nlm.nih.gov/29616625