Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ryan M Baxter"'
Autor:
Ryan M. Baxter, Christine S. Wang, Josselyn E. Garcia-Perez, Daniel S. Kong, Brianne M. Coleman, Valentyna Larchenko, Ronald P. Schuyler, Conner Jackson, Tusharkanti Ghosh, Pratyaydipta Rudra, Debdas Paul, Manfred Claassen, Rosemary Rochford, John C. Cambier, Debashis Ghosh, Jennifer C. Cooper, Mia J. Smith, Elena W. Y. Hsieh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMost childhood-onset SLE patients (cSLE) develop lupus nephritis (cLN), but only a small proportion achieve complete response to current therapies. The prognosis of children with LN and end-stage renal disease is particularly dire. Mortal
Externí odkaz:
https://doaj.org/article/a41397a204e54b1f9e4f77656d9bf4c0
Autor:
Zachary C. Stensland, Brianne M. Coleman, Marynette Rihanek, Ryan M. Baxter, Peter A. Gottlieb, Elena W.Y. Hsieh, Virginia D. Sarapura, Kimber M. Simmons, John C. Cambier, Mia J. Smith
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103626- (2022)
Summary: Autoimmune thyroid disease (AITD) is caused by aberrant activation of the immune system allowing autoreactive B and T cells to target the thyroid gland leading to disease. Although AITD is more frequently diagnosed in adults, children are al
Externí odkaz:
https://doaj.org/article/30cb121fcd7e4390ab3193f5172a949c
Autor:
Ronald P. Schuyler, Conner Jackson, Josselyn E. Garcia-Perez, Ryan M. Baxter, Sidney Ogolla, Rosemary Rochford, Debashis Ghosh, Pratyaydipta Rudra, Elena W. Y. Hsieh
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Cytometry by Time-Of-Flight (CyTOF) uses antibodies conjugated to isotopically pure metals to identify and quantify a large number of cellular features with single-cell resolution. A barcoding approach allows for 20 unique samples to be pooled and pr
Externí odkaz:
https://doaj.org/article/4b7ed76ef1d74cc0b0a1defbed816dc9
Autor:
Josselyn E. Garcia-Perez, Ryan M. Baxter, Daniel S. Kong, Richard Tobin, Martin McCarter, John M. Routes, James Verbsky, Michael B. Jordan, Cullen M. Dutmer, Elena W. Y. Hsieh
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
CTLA-4 is essential for immune tolerance. Heterozygous CTLA4 mutations cause immune dysregulation evident in defective regulatory T cells with low levels of CTLA-4 expression. Biallelic mutations in LRBA also result in immune dysregulation with low l
Externí odkaz:
https://doaj.org/article/c80be548f8aa430a82d406e1f50aadde
Autor:
Victor G. Lui, Tusharkanti Ghosh, Amy Rymaszewski, Shaoying Chen, Ryan M. Baxter, Daniel S. Kong, Debashis Ghosh, John M. Routes, James W. Verbsky, Elena W. Y. Hsieh
Publikováno v:
Journal of Clinical Immunology.
Autor:
Rosemary Rochford, Hesham Eissa, Ryan M Baxter, Jennifer O. Black, James C. Gumbart, Ralph Quinones, Cullen M. Dutmer, Isabel Z. Fernandez, Judith R. Kelsen, Michael R. Verneris, Ross M. Kedl, Thanmayi Ranganath, Noor Dawany, Daniel S Kong, Karl Lundquist, Josselyn E Garcia-Perez, Edwin F. de Zoeten, Tom C. Nguyen, Csaba Galambos, Elena Vendrame, Elena W Y Hsieh, Kathleen E. Sullivan, Sidney Ogolla, Catherine A. Blish
Publikováno v:
Journal of Experimental Medicine. 216:1255-1267
The pleiotropic actions of interleukin-2 (IL-2) are essential for regulation of immune responses and maintenance of immune tolerance. The IL-2 receptor (IL-2R) is composed of IL-2Rα, IL-2Rβ, and IL-2Rγ subunits, with defects in IL-2Rα and IL-2Rγ
Autor:
Olivia Bailey, Josselyn E Garcia-Perez, Ryan M Baxter, Berenice Cabrera-Martinez, Victor G Lui, Isabel Z Fernandez, Mary J Foster, Rachel Gessner, Laurent Gapin, Eric M Pietras, Ross Kedl, Elena Hsieh
Publikováno v:
The Journal of Immunology. 208:159.08-159.08
Human inborn errors of immunity (IEIs) are a class of genetic disorders caused by monogenic germline mutations that impair the function of the encoded protein. We recently described a novel IEI due to an IL2RB homozygous mutation (p.Pro222_Gln225Del)
Autor:
Isabel Z, Fernandez, Ryan M, Baxter, Josselyn E, Garcia-Perez, Elena, Vendrame, Thanmayi, Ranganath, Daniel S, Kong, Karl, Lundquist, Tom, Nguyen, Sidney, Ogolla, Jennifer, Black, Csaba, Galambos, James C, Gumbart, Noor, Dawany, Judith R, Kelsen, Edwin F, de Zoeten, Ralph, Quinones, Hesham, Eissa, Michael R, Verneris, Kathleen E, Sullivan, Rosemary, Rochford, Catherine A, Blish, Ross M, Kedl, Cullen M, Dutmer, Elena W Y, Hsieh
Publikováno v:
The Journal of Experimental Medicine
A novel homozygous mutation in human IL2RB results in decreased IL-2Rβ protein expression and dysregulated IL-2/15 signaling. This hypomorphic mutation leads to decreased regulatory T cell frequency and an abnormal NK cell compartment, with clinical
Autor:
Isabel Z, Fernandez, Ryan M, Baxter, Josselyn E, Garcia-Perez, Elena, Vendrame, Thanmayi, Ranganath, Daniel S, Kong, Karl, Lundquist, Tom, Nguyen, Sidney, Ogolla, Jennifer, Black, Csaba, Galambos, James C, Gumbart, Noor, Dawany, Judith R, Kelsen, Edwin F, de Zoeten, Ralph, Quinones, Hesham, Eissa, Michael R, Verneris, Kathleen E, Sullivan, Rosemary, Rochford, Catherine A, Blish, Ross M, Kedl, Cullen M, Dutmer, Elena W Y, Hsieh
Publikováno v:
The Journal of Experimental Medicine
The pleiotropic actions of interleukin-2 (IL-2) are essential for regulation of immune responses and maintenance of immune tolerance. The IL-2 receptor (IL-2R) is composed of IL-2Rα, IL-2Rβ, and IL-2Rγ subunits, with defects in IL-2Rα and IL-2Rγ
Publikováno v:
Infection and Immunity. 83:4194-4203
Dormancy holds a vital role in the ecological dynamics of microorganisms. Specifically, entry into dormancy allows cells to withstand times of stress while maintaining the potential for reentry into an active existence. The viable but nonculturable (