Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Ryan M Ames"'
Autor:
Zineb Ammous, Lettie E Rawlins, Hannah Jones, Joseph S Leslie, Olivia Wenger, Ethan Scott, Jim Deline, Tom Herr, Rebecca Evans, Angela Scheid, Joanna Kennedy, Barry A Chioza, Ryan M Ames, Harold E Cross, Erik G Puffenberger, Lorna Harries, Emma L Baple, Andrew H Crosby
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009803 (2021)
SNIP1 (Smad nuclear interacting protein 1) is a widely expressed transcriptional suppressor of the TGF-β signal-transduction pathway which plays a key role in human spliceosome function. Here, we describe extensive genetic studies and clinical findi
Externí odkaz:
https://doaj.org/article/2f9a3a5365ad4563a237423cdb93c9ca
Autor:
Judith R Meakin, Ryan M Ames, J Charles G Jeynes, Jo Welsman, Michael Gundry, Karen Knapp, Richard Everson
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0222523 (2019)
The development of automatic methods for segmenting anatomy from medical images is an important goal for many medical and healthcare research areas. Datasets that can be used to train and test computer algorithms, however, are often small due to the
Externí odkaz:
https://doaj.org/article/840e5789f58f40409efdb7529e181a54
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99480 (2014)
The complement of genes found in the genome is a balance between gene gain and gene loss. Knowledge of the specific genes that are gained and lost over evolutionary time allows an understanding of the evolution of biological functions. Here we use ne
Externí odkaz:
https://doaj.org/article/4b1060590b6345e4a044e668dbdfb2a5
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62670 (2013)
Large-scale molecular interaction data sets have the potential to provide a comprehensive, system-wide understanding of biological function. Although individual molecules can be promiscuous in terms of their contribution to function, molecular functi
Externí odkaz:
https://doaj.org/article/7720d5fa451f47b68fd9e7e753877bf3
Autor:
Ryan M. Ames, Akshay Bhinge, Seema C. Namboori, Patricia Thomas, Lawrence W. Stanton, Alessandro Rosa, Lawrence O. Garrett, Craig R. G. Willis, Sophie Hawkins
Publikováno v:
Stem Cell Reports
Summary Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by the loss of motor neurons. We utilized single-cell transcriptomics to uncover dysfunctional pathways in degenerating motor neurons differentiated from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2a2e36be067b01723d8dcc982f898b
https://doi.org/10.1016/j.stemcr.2021.10.010
https://doi.org/10.1016/j.stemcr.2021.10.010
Autor:
Craig R. G. Willis, Colleen S. Deane, Ryan M. Ames, Joseph J. Bass, Daniel J. Wilkinson, Kenneth Smith, Bethan E. Phillips, Nathaniel J. Szewczyk, Philip J. Atherton, Timothy Etheridge
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Eccentric (ECC) and concentric (CON) contractions induce distinct muscle remodelling patterns that manifest early during exercise training, the causes of which remain unclear. We examined molecular signatures of early contraction mode-specific muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1665577539cb123432364a6d58f841
https://doaj.org/article/fe0c75ea1c924a239e9c9b0a609be2ea
https://doaj.org/article/fe0c75ea1c924a239e9c9b0a609be2ea
Autor:
Timothy Etheridge, Nathaniel J. Szewczyk, Lorna W. Harries, Colleen S. Deane, Bethan E. Phillips, Craig R. G. Willis, Ryan M. Ames, Philip J. Atherton
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 3, Pp 629-645 (2021)
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 3, Pp 629-645 (2021)
Background Skeletal muscle atrophy manifests across numerous diseases; however, the extent of similarities/differences in causal mechanisms between atrophying conditions in unclear. Ageing and disuse represent two of the most prevalent and costly atr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd05fb5079b2e3e9f71d6597f22f691
https://doi.org/10.1002/jcsm.12706
https://doi.org/10.1002/jcsm.12706
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-15 (2020)
BMC Medical Genomics
BMC Medical Genomics
Background Circular RNAs are non-coding RNA molecules with gene regulatory potential that have been associated with several human diseases. They are stable and present in the circulation, making them excellent candidates for biomarkers of disease. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1471a4864899fcffaae63b57c4792be0
http://link.springer.com/article/10.1186/s12920-020-0713-2
http://link.springer.com/article/10.1186/s12920-020-0713-2
Autor:
Lorna W. Harries, Luanne L. Peters, Luigi Ferrucci, Shahnaz Haque, Stefania Bandinelli, Karen Moore, Luke C. Pilling, Ryan M. Ames
Publikováno v:
GeroScience
Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite the observation that circRNAs are known to accumulate in older organisms and have been reported in cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce15b97f5eb0f5e34e332e330b32a3b6
https://doi.org/10.1007/s11357-019-00120-z
https://doi.org/10.1007/s11357-019-00120-z
Autor:
Hannah Jones, Tom Herr, Lorna W. Harries, Erik G. Puffenberger, Rebecca Evans, Harold E. Cross, Olivia Wenger, Angela Scheid, Ethan M. Scott, Jim Deline, Joanna Kennedy, Emma L. Baple, Lettie E. Rawlins, Zineb Ammous, Ryan M. Ames, Joseph S Leslie, Andrew H. Crosby, Barry A. Chioza
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009803 (2021)
PLoS Genetics
PLoS Genetics
SNIP1 (Smad nuclear interacting protein 1) is a widely expressed transcriptional suppressor of the TGF-β signal-transduction pathway which plays a key role in human spliceosome function. Here, we describe extensive genetic studies and clinical findi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a1ec8bc51f04bdbc7cf73254007e68
https://doaj.org/article/2f9a3a5365ad4563a237423cdb93c9ca
https://doaj.org/article/2f9a3a5365ad4563a237423cdb93c9ca