Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ryan M, Pedrigi"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2024)
Introduction: Cataract surgery permanently alters the mechanical environment of the lens capsule by placing a hole in the anterior portion and implanting an intraocular lens (IOL) that has a very different geometry from the native lens. We hypothesiz
Externí odkaz:
https://doaj.org/article/9bc7adbecc3b48548800d5fe6950d9d2
Autor:
Morgan A. Schake, Ian S. McCue, Evan T. Curtis, Thomas J. Ripperda, Jr., Samuel Harvey, Bryan T. Hackfort, Anna Fitzwater, Yiannis S. Chatzizisis, Forrest M. Kievit, Ryan M. Pedrigi
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106760- (2023)
Summary: Blood flow is a key regulator of atherosclerosis. Disturbed blood flow promotes atherosclerotic plaque development, whereas normal blood flow protects against plaque development. We hypothesized that normal blood flow is also therapeutic, if
Externí odkaz:
https://doaj.org/article/df5f6f2cf0e9416f9819145b79319fb8
Autor:
Martin Liu, Saurabhi Samant, Charu Hasini Vasa, Ryan M Pedrigi, Usama M Oguz, Sangjin Ryu, Timothy Wei, Daniel R Anderson, Devendra K Agrawal, Yiannis S Chatzizisis
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280385 (2023)
BackgroundThis work aims to present a fast, affordable, and reproducible three-cell co-culture system that could represent the different cellular mechanisms of atherosclerosis, extending from atherogenesis to pathological intimal thickening.Methods a
Externí odkaz:
https://doaj.org/article/40ce24ab18774f39b6a4d40714602de3
Autor:
Hunter A. Miller, Morgan A. Schake, Badrul Alam Bony, Evan T. Curtis, Connor C. Gee, Ian S. McCue, Thomas J. Ripperda, Yiannis S. Chatzizisis, Forrest M. Kievit, Ryan M. Pedrigi
Publikováno v:
PLoS ONE, Vol 16, Iss 12 (2021)
Atherosclerosis is a lipid-driven chronic inflammatory disease that leads to the formation of plaques in the inner lining of arteries. Plaques form over a range of phenotypes, the most severe of which is vulnerable to rupture and causes most of the c
Externí odkaz:
https://doaj.org/article/4b707e23dec44e80ab8291c434d82721
Autor:
Rosa Nikolopoulou, Sean Herault, Ryan M. Pedrigi, Miten Patel, Daniele Carassiti, Rob Krams, Marti Llopart Font, Jarka Naser, K Yean Chooi
Publikováno v:
Biophys Rev
Shear stress is known to affect many processes in (patho-) physiology through a complex, multi-molecular mechanism, termed mechanotransduction. The sheer complexity of the process has raised questions how mechanotransduction is regulated. Here, we co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3865b56328cbd8dc7e1e33ebc300968b
https://doi.org/10.1007/s12551-021-00839-0
https://doi.org/10.1007/s12551-021-00839-0
Autor:
Jaideep Sahni, Mehwish Arshad, Morgan A. Schake, Justin R. Brooks, Ruiguo Yang, Peter D. Weinberg, Ryan M. Pedrigi
Publikováno v:
Journal of the mechanical behavior of biomedical materials. 137
Complex patterns of hemodynamic wall shear stress occur in regions of arterial branching and curvature. Areas within these regions can be highly susceptible to atherosclerosis. Although many studies have characterized the response of vascular endothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7e2a2e1c89ed511995fa9de3fe54b3
https://pubmed.ncbi.nlm.nih.gov/36368188
https://pubmed.ncbi.nlm.nih.gov/36368188
Autor:
Ryan M. Pedrigi, Vikram V. Mehta, Sandra M. Bovens, Zahra Mohri, Christian Bo Poulsen, Willy Gsell, Jordi L. Tremoleda, Leila Towhidi, Ranil de Silva, Enrico Petretto, Rob Krams
Publikováno v:
Royal Society Open Science, Vol 3, Iss 10 (2016)
The precise flow characteristics that promote different atherosclerotic plaque types remain unclear. We previously developed a blood flow-modifying cuff for ApoE−/− mice that induces the development of advanced plaques with vulnerable and stable
Externí odkaz:
https://doaj.org/article/76fe35acac5d4fd48f6f80f7901a76a6
Publikováno v:
J Biomech
The lens capsule of the eye is important in focusing light onto the retina during the process of accommodation and, in later life, housing a prosthetic lens implanted during cataract surgery. Though considerable modeling work has characterized the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e3829c7c73583449dbf03bd8abfeac
https://pubmed.ncbi.nlm.nih.gov/33223144
https://pubmed.ncbi.nlm.nih.gov/33223144
Publikováno v:
Computer Methods in Biomechanics and Biomedical Engineering. 20:302-307
Accommodation of the eyes, the mechanism that allows humans to focus their vision on near objects, naturally diminishes with age via presbyopia. People who have undergone cataract surgery, using current surgical methods and artificial lens implants,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c37030ece6df295433e2d9c98e999b
https://doi.org/10.1080/10255842.2016.1228907
https://doi.org/10.1080/10255842.2016.1228907
Autor:
Paul Cernohorsky, Rob Krams, Geert J. Streekstra, Ton G. van Leeuwen, Anouk L. Post, Daniel M. de Bruin, Jouke T. Annema, Simon D. Strackee, Julia N S d'Hooghe, Ryan M. Pedrigi, Dirk J. Faber
Publikováno v:
OSA Continuum, 3(10), 2707-2721. OSA-The Optical Society
Applications of catheter-based optical coherence tomography (OCT) - originally developed for cardiovascular imaging - have expanded to other organ systems. However, currently available algorithms to co-register 3D OCT data to a second imaging modalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6866c633624c5eea4e367897bb25357
https://doi.org/10.1364/osac.401599
https://doi.org/10.1364/osac.401599