Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Ryan M, Kramer"'
Autor:
Michelle C. Archer, Joseph McCollum, Christopher Press, Timothy S. Dutill, Hong Liang, Dawn Fedor, Liam Kapilow-Cohen, Alana Gerhardt, Tony Phan, Edward H. Trappler, Mark T. Orr, Ryan M. Kramer, Christopher B. Fox
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e17325- (2023)
With the recent exception of coronavirus disease 2019 (COVID-19), tuberculosis (TB) causes more deaths globally than any other infectious disease, and approximately 1/3 of the world's population is infected with Mycobacterium tuberculosis (Mtb). Howe
Externí odkaz:
https://doaj.org/article/88a87a77075d4c7299e7f265a7c71fc3
Autor:
Mellissa Gomez, Mushtaq Ahmed, Shibali Das, Joseph McCollum, Leah Mellett, Rosemary Swanson, Ananya Gupta, Nicholas B. Carrigy, Hui Wang, David Barona, Shital Bachchhav, Alana Gerhardt, Chris Press, Michelle C. Archer, Hong Liang, Emilie Seydoux, Ryan M. Kramer, Philip J. Kuehl, Reinhard Vehring, Shabaana A. Khader, Christopher B. Fox
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Converting a vaccine into a thermostable dry powder is advantageous as it reduces the resource burden linked with the cold chain and provides flexibility in dosage and administration through different routes. Such a dry powder presentation may be esp
Externí odkaz:
https://doaj.org/article/0867992eddca47cd99591c4ade285336
Autor:
Timothy S. Dutill, Michelle C. Archer, Joseph McCollum, Chris Press, Lisa McNeill, Linda Hawkins, Tony Phan, Erik D. Laursen, Richard Cabullos, Lisa Bouchard, Regie J. Castro, Mong-Wu Lin, Jeralyn Roco, Cecile Blois, Babatunde A. Adeagbo, Jeffrey A. Guderian, Alana Gerhardt, Anna Marie Beckmann, Edward H. Trappler, Ryan M. Kramer, Christopher B. Fox
Publikováno v:
Frontiers in Drug Delivery. 2
Promising clinical efficacy results have generated considerable enthusiasm for the potential impact of adjuvant-containing subunit tuberculosis vaccines. The development of a thermostable tuberculosis vaccine formulation could have significant benefi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdf232176abd7a50242b9107e7814b9d
https://doi.org/10.3389/fddev.2022.1043756
https://doi.org/10.3389/fddev.2022.1043756
Autor:
Joseph McCollum, Mellissa Gomez, Ryan M. Kramer, Mani Ordoubadi, Alana Gerhardt, Zheng Wang, Michelle Archer, Christopher B. Fox, Chris Press, David Barona, Shabab Bin Karim, Reinhard Vehring, Hui Wang, Nicholas B. Carrigy
Publikováno v:
Eur J Pharm Biopharm
Spray drying is a technique that can be used to stabilize biopharmaceuticals, such as vaccines, within dry particles. Compared to liquid pharmaceutical products, dry powder has the potential to reduce costs associated with refrigerated storage and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113b933a808b8e7d7ace418ff65ac848
https://doi.org/10.1016/j.ejpb.2021.03.007
https://doi.org/10.1016/j.ejpb.2021.03.007
Autor:
Hui Wang, Isobel Tetreau, Ryan M. Kramer, Chris Press, Joseph McCollum, Alana Gerhardt, Christopher B. Fox, Mellissa Gomez, Shital Bachchhav, Reinhard Vehring
Publikováno v:
Vaccine. 39(35)
Particle engineering via spray drying was used to develop a dry powder presentation of an adjuvanted tuberculosis vaccine candidate. This presentation utilizing a trileucine-trehalose excipient system was designed to be both thermostable and suitable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0592b5a77d044c94cf1463f3b5fdaa41
https://pubmed.ncbi.nlm.nih.gov/34256969
https://pubmed.ncbi.nlm.nih.gov/34256969
Autor:
Christopher B. Fox, Alana Gerhardt, Corey Casper, Elise Larson, Emily A. Voigt, Ryan M. Kramer, Steve Reed, Van Hoeven N, Michelle Archer
Current RNA vaccines against SARS-CoV-2 are limited by instability of both the RNA and the lipid nanoparticle delivery system, requiring storage at −20°C or −70°C and compromising universally accessible vaccine distribution. This study demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::604a5c4f7860960b343dd511ad21c015
https://doi.org/10.1101/2021.02.01.429283
https://doi.org/10.1101/2021.02.01.429283
Autor:
Isobel Tetreau, Mani Ordoubadi, Alana Gerhardt, Joseph McCollum, Michelle Archer, Nicholas B. Carrigy, Reinhard Vehring, Ryan M. Kramer, Christopher B. Fox, Chris Press, Mellissa Gomez, Chester Jar, Hui Wang, David Barona
Publikováno v:
Int J Pharm
Protection against primarily respiratory infectious diseases, such as tuberculosis (TB), can likely be enhanced through mucosal immunization induced by direct delivery of vaccines to the nose or lungs. A thermostable inhalable dry powder vaccine offe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22c7292d1e6ce5a3adc76e2b30d865b
https://pubmed.ncbi.nlm.nih.gov/33278492
https://pubmed.ncbi.nlm.nih.gov/33278492
Publikováno v:
Journal of Computational and Nonlinear Dynamics. 15
Understanding the mechanisms behind human balance has been a subject of interest as various postural instabilities have been linked to neuromuscular diseases (e.g., Parkinson's, multiple sclerosis, and concussion). This paper presents a method to cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c343cfa33a53939a6d27e53c0030b139
https://doi.org/10.1115/1.4047937
https://doi.org/10.1115/1.4047937
Autor:
Jacob Archer, Elise Larson, Jasmine Fuerte-Stone, Brian Granger, Neal Van Hoeven, Emily Gage, Dan T. Stinchcomb, Susan Lin, Steven G. Reed, Rhea N. Coler, Michelle Archer, Jeff Guderian, Jesse H. Erasmus, Amit P. Khandhar, Christopher B. Fox, Ryan M. Kramer
Publikováno v:
Molecular Therapy. 26:2507-2522
Since the first demonstration of in vivo gene expression from an injected RNA molecule almost two decades ago,(1) the field of RNA-based therapeutics is now taking significant strides, with many cancer and infectious disease targets entering clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5056546a013655821aae0ca0809b73
https://doi.org/10.1016/j.ymthe.2018.07.010
https://doi.org/10.1016/j.ymthe.2018.07.010
Autor:
Sang Ah Kim, Adam F. Barrios, Svitlana Usatyuk, Judy Luke, Vincent Lu, Jian Sun, Song Tan, Ryan M. Kramer, Anthony A. Kossiakoff, Marcin Paduch
Publikováno v:
Proceedings of the National Academy of Sciences. 115:10010-10015
The Gcn5 histone acetyltransferase (HAT) subunit of the SAGA transcriptional coactivator complex catalyzes acetylation of histone H3 and H2B N-terminal tails, posttranslational modifications associated with gene activation. Binding of the SAGA subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6033c689039865256620ca9da86a1663
https://doi.org/10.1073/pnas.1805343115
https://doi.org/10.1073/pnas.1805343115