Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Ryan M, Fryer"'
Autor:
Peng, Sun, Christina S, Bartlett, Chao, Zheng, Tammy, Bigwarfe, Joshuaine M, Grant, Margit, MacDougall, Valentina, Berger, Steven, Kerr, Hu Sheng, Qian, Mark, McHugh, Hongxing, Chen, Xiaomei, Zhang, Miranda L, Carpenter, Heather N, Robinson, John, Miglietta, Thorsten, Lamla, Ryan M, Fryer
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 382:266-276
Diabetic nephropathy is a leading cause of end-stage renal disease, characterized by endothelial dysfunction and a compromised glomerular permeability barrier. Dysregulation of the angiopoietin 1 (ANGPT1)/angiopoietin 2 (ANGPT2) signaling axis is imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374bd8d82a45deba15901277988434a3
https://doi.org/10.1124/jpet.121.001067
https://doi.org/10.1124/jpet.121.001067
Autor:
Glenn A. Reinhart, Paul C. Harrison, Kathleen Lincoln, Hongxing Chen, Peng Sun, Jon Hill, Hu Sheng Qian, Mark C. McHugh, Holly Clifford, Khing Jow Ng, Hong Wang, Danielle Fowler, Kristina Gueneva-Boucheva, Jehrod B. Brenneman, Todd Bosanac, Diane Wong, Ryan M. Fryer, Chris Sarko, Carine M. Boustany-Kari, Steven S. Pullen
Publikováno v:
The Journal of pharmacology and experimental therapeutics.
Activation of soluble guanylate cyclase (sGC) to restore cyclic guanosine monophosphate (cGMP) and improve functionality of nitric oxide (NO) pathways impaired by oxidative stress is a potential treatment for diabetic and chronic kidney disease. We r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62247eda3ea47ef82756bd1ee47aafe3
https://pubmed.ncbi.nlm.nih.gov/36507845
https://pubmed.ncbi.nlm.nih.gov/36507845
Autor:
Ryan M Fryer, Mita Patel, Xiaomei Zhang, Katja S Baum-Kroker, Akalushi Muthukumarana, Brian Linehan, Yin-Chao Tseng
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Establishing a wide therapeutic index (TI) for pre-clinical safety is important during lead optimization (LO) in research, prior to clinical development, although is often limited by a molecules physiochemical characteristics. Recent advances in the
Externí odkaz:
https://doaj.org/article/f23ed065d90641de85aa0a48e9ca1c0d
Autor:
Hu Sheng Qian, Steve M Weldon, Damian Matera, ChungWein Lee, Haichun Yang, Ryan M Fryer, Agnes B Fogo, Glenn A Reinhart
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156734 (2016)
Renal interstitial fibrosis (IF) is an important pathologic manifestation of disease progression in a variety of chronic kidney diseases (CKD). However, the quantitative and reproducible analysis of IF remains a challenge, especially in experimental
Externí odkaz:
https://doaj.org/article/a993e99f265d4718a12f74a371641003
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Externí odkaz:
https://doaj.org/article/2e61fb2ee39746faa2d30dc3f23407d9
Autor:
Nuruddeen D Lewis, Akalushi Muthukumarana, Steven E Fogal, Laura Corradini, Dimitria E Stefanopoulos, Prathima Adusumalli, Josephine Pelletier, Mark Panzenbeck, Karen Berg, Melissa Canfield, Brian N Cook, Hossein Razavi, Daniel Kuzmich, Shawn Anderson, Devan Allard, Paul Harrison, Christine Grimaldi, Donald Souza, Christian Harcken, Ryan M Fryer, Louise K Modis, Maryanne L Brown
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105883 (2014)
Inflammation is associated with immune cells infiltrating into the inflammatory site and pain. CC chemokine receptor 1 (CCR1) mediates trafficking of leukocytes to sites of inflammation. However, the contribution of CCR1 to pain is incompletely under
Externí odkaz:
https://doaj.org/article/81669bfd30b848adb34caf77ca3b6e5b
Autor:
Kathleen Hoyt, Kim Fletcher, Christian Harcken, Steven Richard Brunette, T. Gregg Davis, Delphine Collin, Ryan M. Fryer, Robert Sibley, Thomas Wieckowski, Jörg P Hehn, Dustin Smith, Yin-Chao Tseng, Stanley Kugler, Csengery Johanna, Donald Souza, Liang Shuang, Michael Robert Turner, Mark E. Labadia, Donna Terenzio, Anita L. Wayne, Mark Panzenbeck, Wu Lifen, Robert Hughes
Publikováno v:
ACS Med Chem Lett
[Image: see text] The interleukin (IL)-23/T helper (Th)17 axis plays a critical role in autoimmune diseases, and there is an increasing number of biologic therapies that target IL-23 and IL-17. The transcription factor retinoic acid receptor-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86af9280bb7f85b4a15b0ef59af3fcc
https://pubmed.ncbi.nlm.nih.gov/33488976
https://pubmed.ncbi.nlm.nih.gov/33488976
Autor:
Ryan M Fryer, Akalushi Muthukumarana, Paul C Harrison, Suzanne Nodop Mazurek, Rong Rhonda Chen, Kyle E Harrington, Roger M Dinallo, Joshua C Horan, Lori Patnaude, Louise K Modis, Glenn A Reinhart
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52985 (2012)
Sphingosine-1-phospate (S1P) and S1P receptor agonists elicit mechanism-based effects on cardiovascular function in vivo. Indeed, FTY720 (non-selective S1P(X) receptor agonist) produces modest hypertension in patients (2-3 mmHg in 1-yr trial) as well
Externí odkaz:
https://doaj.org/article/08570c9c255342e7a483aa39d2774669
Autor:
David B. Hayes, Ryan M. Fryer, Rachel Kroe-Barrett, Sanjaya Singh, James D. Smith, Peng Sun, Margit MacDougall, Kristin Bovat, Joshuaine Toth, Kavita Jerath, Chao Zheng, Tammy Bigwarfe
Publikováno v:
mAbs
Ang1 is a soluble ligand to receptor Tie2, and increasing the circulating Ang1 level may improve vascular stabilization under certain disease conditions. Here, we found that the circulating Ang1 level was significantly increased in cynomolgus monkeys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8f100ac1c7308df1c03be75ebc9bb4
https://doi.org/10.1080/19420862.2018.1521130
https://doi.org/10.1080/19420862.2018.1521130
Autor:
Kristina Gueneva-Boucheva, Chris Sarko, Hong Wang, Holly Clifford, Ryan M. Fryer, Hu Sheng Qian, Todd Bosanac, Kathleen A Lincoln, Jeremy Richman, Carine M. Boustany-Kari, Diane Wong, Hongxing Chen, Xiaomei Zhang, Paul C. Harrison, Steven S. Pullen
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 356:712-719
Therapies that restore renal cGMP levels are hypothesized to slow the progression of diabetic nephropathy. We investigated the effect of BI 703704, a soluble guanylate cyclase (sGC) activator, on disease progression in obese ZSF1 rats. BI 703704 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95609501cd699f0fc38a0d6c48276bb0
https://doi.org/10.1124/jpet.115.230706
https://doi.org/10.1124/jpet.115.230706