Výsledky vyhledávání

Genetically engineering endothelial niche in human kidney organoids enables multilineage maturation, vascularization, and de novo cell types

Vascularization plays a critical role in organ maturation and cell type development. Drug discovery, organ mimicry, and ultimately transplantation in a clinical setting thereby hinges on achieving robust vascularization of in vitro engineered organs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a832bb2fd956b83cba53f6fdf775582
https://doi.org/10.1101/2023.05.30.542848

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Gene regulatory network analysis and engineering directs development and vascularization of multilineage human liver organoids

Autor: Farzaneh Moghadam, Yuqi Tan, Silvia Liu, Susana M. Chuva de Sousa Lopes, Mo R. Ebrahimkhani, Joseph C. Maggiore, Joshua Hislop, Jeremy J. Velazquez, Davy Cats, Patrick Cahan, Christopher L. Plaisier, Ryan LeGraw, Samira Kiani, Jacquelyn Kilbourne

Publikováno v: Cell Systems, 12(1), 41-55.e11. Elsevier
Trends Genet

Summary Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models of human tissue development but display immature phenotypes, aberrant tissue fates, and a limited subset of cells. Here, we demonstrate that integrated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef984817d983a940da7411dc9fc419ff
http://hdl.handle.net/1887/3280148

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Synthetic Maturation of Multilineage Human Liver Organoids via Genetically Guided Engineering

Autor: Jeremy J. Velazquez, Shi Tong Liu, Jacquelyn Kilbourne, Farzaneh Moghadam, Christopher L. Plaisier, Yuqi Tan, Ryan LeGraw, Mo R. Ebrahimkhani, Davy Cats, Susana M. Chuva de Sousa Lopes, Joshua Hislop, Samira Kiani, Patrick Cahan

SUMMARYPluripotent stem cell (PSC)-derived organoids are emerging as novel human-based microphysiological models but display immature phenotypes with limited subsets of endothelial or stromal cells. Here we demonstrate that in vitro manipulation of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90a728c6249b275459fecc216928cf9

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Synthetic immunomodulation with a CRISPR super-repressor in vivo

Autor: Jin Park, Samira Kiani, Ryan LeGraw, Farzaneh Moghadam, Chenxi Xu, Mo R. Ebrahimkhani, Jeremy J. Velazquez, Alejandro Chavez, Nan Cher Yeo

Publikováno v: Nature cell biology

Transient modulation of the genes involved in immunity, without exerting a permanent change in the DNA code, can be an effective strategy to modulate the course of many inflammatory conditions. CRISPR-Cas9 technology represents a promising platform f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dee67a6c4a1abc88f496287780614ce
https://pubmed.ncbi.nlm.nih.gov/32884147