Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ryan L. O'Hare Doig"'
Autor:
Ryan L. O’Hare Doig, Sreya Santhakumar, Brooke Fehily, Sushmitha Raja, Tanya Solomon, Carole A. Bartlett, Melinda Fitzgerald, Stuart I. Hodgetts
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Reducing the extent of secondary degeneration following spinal cord injury (SCI) is necessary to preserve function, but treatment options have thus far been limited. A combination of the ion channel inhibitors Lomerizine (Lom), YM872 and oxATP, to in
Externí odkaz:
https://doaj.org/article/14d6a50030fe4f2fbbe32f497cbe1789
Autor:
Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey, Melinda Fitzgerald
Publikováno v:
BMC Neuroscience, Vol 18, Iss 1, Pp 1-16 (2017)
Abstract Background Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metab
Externí odkaz:
https://doaj.org/article/1f6e5113e52a4da8841df25ed981e229
Autor:
Christine D. Gayen, Madeleine A. Bessen, Ryan M. Dorrian, Ryan D. Quarrington, Adnan Mulaibrahimovic, Ryan L. O'Hare Doig, Brian J.C. Freeman, Anna V. Leonard, Claire F. Jones
Publikováno v:
Journal of neurotrauma.
Spinal cord injury (SCI) frequently results in motor, sensory, and autonomic dysfunction for which there is currently no cure. Recent pre-clinical and clinical research has led to promising advances in treatment; however, therapeutics indicating prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726712601d410548070ab37b63cbe4c5
https://pubmed.ncbi.nlm.nih.gov/36200622
https://pubmed.ncbi.nlm.nih.gov/36200622
Autor:
Dusan Losic, Negar Mansouri, Jillian Clark, Said F. Al-Sarawi, Stan Gronthos, Ryan L. O'Hare Doig, Jagan Mazumdar
Publikováno v:
Biotechnology and Bioengineering. 118:4217-4230
Neural tissue engineering aims to restore function of nervous system tissues using biocompatible cell-seeded scaffolds. Graphene-based scaffolds combined with stem cells deserve special attention to enhance tissue regeneration in a controlled manner.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2537ef59ace3951197bdea81468cc5
https://doi.org/10.1002/bit.27891
https://doi.org/10.1002/bit.27891
Autor:
Melinda Fitzgerald, Carole A. Bartlett, Alan R. Harvey, Stuart I. Hodgetts, Nathanael J. Yates, Ryan L. O'Hare Doig, Wissam Chiha, Nicole M. Smith, Marcus K. Giacci
Publikováno v:
BMC Neuroscience, Vol 18, Iss 1, Pp 1-16 (2017)
BMC Neuroscience
BMC Neuroscience
© 2017 The Author(s). Background: Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498aeff74b268ca616c9a52f46679ccd
http://link.springer.com/article/10.1186/s12868-017-0380-1
http://link.springer.com/article/10.1186/s12868-017-0380-1
Autor:
Diego Milani, Adam B. Edwards, Bruno P. Meloni, Melinda Fitzgerald, Ryan S. Anderton, Neville W. Knuckey, T. Norman Palmer, Ryan L. O'Hare Doig
Publikováno v:
Pharmacology & Therapeutics. 153:36-54
Several recent studies have demonstrated that TAT and other arginine-rich cell penetrating peptides (CPPs) have intrinsic neuroprotective properties in their own right. Examples, we have demonstrated that in addition to TAT, poly-arginine peptides (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c1c7aa992d5c89979f41c9437cdd71
https://doi.org/10.1016/j.pharmthera.2015.06.002
https://doi.org/10.1016/j.pharmthera.2015.06.002
Autor:
Jennifer Rodger, K. Swaminathan Iyer, Carole A. Bartlett, Greg Cozens, Ryan L. O'Hare Doig, Sarah A. Dunlop, Melinda Fitzgerald, Celeste H. Wale, Paula I. Fuller, Michael Challenor, Livia C. Hool, Marcus K. Giacci
Publikováno v:
Biochimie. 112:160-171
Glutamate excitotoxicity contributes to damage following injury to the central nervous system via mechanisms including changes in the expression of receptors, calcium overload, oxidative stress and cell death. Excitotoxicity is triggered by glutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8f074b2ffc6e5f6405672f34be6b21
https://doi.org/10.1016/j.biochi.2015.03.008
https://doi.org/10.1016/j.biochi.2015.03.008
Autor:
Ryan L, O'Hare Doig, Carole A, Bartlett, Nicole M, Smith, Stuart I, Hodgetts, Sarah A, Dunlop, Livia, Hool, Melinda, Fitzgerald
Publikováno v:
Neuroscience. 339
Combinations of Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40142e024b20c28f12b2c88e9875dd61
https://pubmed.ncbi.nlm.nih.gov/27725216
https://pubmed.ncbi.nlm.nih.gov/27725216
Publikováno v:
Discovery medicine. 19(102)
Neurotrauma results in the progressive degeneration of neurons and glia surrounding the initial injury. Disruptions to myelin structure are a feature of these injuries and are thought to be triggered by excess calcium (Ca2+) influx into myelinating o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d34f72426669e3684fd78d821f9d4d7
https://pubmed.ncbi.nlm.nih.gov/25636960
https://pubmed.ncbi.nlm.nih.gov/25636960
Autor:
Jade E. Kenna, Ryan L. O'Hare Doig, Nathanael J. Yates, Marcus K. Giacci, Wissam Chiha, Carole A. Bartlett, Melinda Fitzgerald, Bethany Eve Ashworth
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 2, Pp 307-316 (2017)
Neural Regeneration Research
Neural Regeneration Research
Studies have shown that a combined application of several ion channel inhibitors immediately after central nervous system injury can inhibit secondary degeneration. However, for clinical use, it is necessary to determine how long after injury the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8f9076e2ee0679cb4344fc25411ee6
https://doi.org/10.4103/1673-5374.200814
https://doi.org/10.4103/1673-5374.200814