Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Ryan L. Boudreau"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 1-15 (2022)
Parkinson's disease (PD) is caused by the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Although PD pathogenesis is not fully understood, studies implicate perturbations in gene regulation, mitochondrial function, and neuronal activ
Externí odkaz:
https://doaj.org/article/71f1e37f633542c0a96605c8fddb3cce
Autor:
Manuela Escudero-Flórez, David Torres-Hoyos, Yaneth Miranda-Brand, Ryan L. Boudreau, Juan Carlos Gallego-Gómez, Miguel Vicente-Manzanares
Publikováno v:
Viruses, Vol 15, Iss 11, p 2252 (2023)
Ryan L [...]
Externí odkaz:
https://doaj.org/article/787ff7cb44be490ba72a1b56d1158d00
Autor:
Nizar Y. Saad, Mustafa Al-Kharsan, Sara E. Garwick-Coppens, Gholamhossein Amini Chermahini, Madison A. Harper, Andrew Palo, Ryan L. Boudreau, Scott Q. Harper
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Facioscapulohumeral muscular dystrophy is a myopathy caused by aberrant de-repression of the DUX4 gene. Here, the authors show that miR-675 inhibits DUX4 expression and protects muscles from DUX4-mediated cell death when administered to mice using AA
Externí odkaz:
https://doaj.org/article/9598bc5d736548bfa909ada1aa74db34
Autor:
Manuela Escudero-Flórez, David Torres-Hoyos, Yaneth Miranda-Brand, Ryan L. Boudreau, Juan Carlos Gallego-Gómez, Miguel Vicente-Manzanares
Publikováno v:
Viruses, Vol 15, Iss 7, p 1437 (2023)
Dengue virus (DENV) is a pathogenic arbovirus that causes human disease. The most severe stage of the disease (severe dengue) is characterized by vascular leakage, hypovolemic shock, and organ failure. Endothelial dysfunction underlies these phenomen
Externí odkaz:
https://doaj.org/article/6352608893284a7abba9bdd53711dbba
Autor:
Jared M. McLendon, Xiaoming Zhang, Daniel S. Matasic, Mohit Kumar, Olha M. Koval, Isabella M. Grumbach, Sakthivel Sadayappan, Barry London, Ryan L. Boudreau
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 13 (2022)
Background Sorbin and SH3 domain containing 2 (Sorbs2) protein is a cytoskeletal adaptor with an emerging role in cardiac biology and disease; yet, its potential relevance to adult‐onset cardiomyopathies remains underexplored. Sorbs2 global knockou
Externí odkaz:
https://doaj.org/article/b196424fa3644aaaa2ddb79eeca7f516
Autor:
Colleen S. Stein, Pooja Jadiya, Xiaoming Zhang, Jared M. McLendon, Gabrielle M. Abouassaly, Nathan H. Witmer, Ethan J. Anderson, John W. Elrod, Ryan L. Boudreau
Publikováno v:
Cell Reports, Vol 23, Iss 13, Pp 3710-3720.e8 (2018)
Summary: Mitochondria are composed of many small proteins that control protein synthesis, complex assembly, metabolism, and ion and reactive oxygen species (ROS) handling. We show that a skeletal muscle- and heart-enriched long non-coding RNA, LINC00
Externí odkaz:
https://doaj.org/article/1aec9d971f9d4cf18785d9de8493e2a1
Autor:
Ryan L. Boudreau
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 9 (2017)
Externí odkaz:
https://doaj.org/article/292299407c0b4af7a6c0eb2ad5cc4c8e
Publikováno v:
Neurobiology of Disease, Vol 56, Iss , Pp 6-13 (2013)
Spinocerebellar Ataxia Type 1 (SCA1) is an autosomal dominant late onset neurodegenerative disease caused by an expanded polyglutamine tract in ataxin-1. Here, we compared the protective effects of overexpressing ataxin-1-like using recombinant AAVs,
Externí odkaz:
https://doaj.org/article/b4657bcb5aa94fbd867ab152a83c24e3
Publikováno v:
Circulation Research. 131
SCN5A encodes the voltage-gated Na + channel Na v 1.5, known for its role in cardiac conduction. However, we recently found unexpected links between lower SCN5A expression and increased non-arrhythmic death in heart failure (HF) patients. To test if
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27842e359775e3a00e783525d6075cf1
https://doi.org/10.1161/res.131.suppl_1.p3034
https://doi.org/10.1161/res.131.suppl_1.p3034
Autor:
Gina M. Morgan, Mark S. Schmidt, Haider Mehdi, Jared M. McLendon, Ryan L. Boudreau, Alexander M. Greiner, Pravda Quinones, Jin-Young Yoon, Daniel S. Matasic, Barry London, Charles Brenner, Kaikobad Irani
Publikováno v:
J Mol Cell Cardiol
RationaleThe cardiac sodium channel NaV1.5, encoded by SCN5A, produces the rapidly inactivating depolarizing current INa that is responsible for the initiation and propagation of the cardiac action potential. Acquired and inherited dysfunction of NaV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d090e7eb0a9fac5899be64d80c8df2
https://doi.org/10.1016/j.yjmcc.2020.01.013
https://doi.org/10.1016/j.yjmcc.2020.01.013