Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ryan L Kelly"'
Autor:
Michelle L Scalley-Kim, Bruce W Hess, Ryan L Kelly, Anne-Rachel F Krostag, Kurt H Lustig, John S Marken, Pamela J Ovendale, Aaron R Posey, Pamela J Smolak, Janelle D L Taylor, C L Wood, David L Bienvenue, Peter Probst, Ruth A Salmon, Daniel S Allison, Teresa M Foy, Carol J Raport
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43332 (2012)
Chemokines play a key role in leukocyte recruitment during inflammation and are implicated in the pathogenesis of a number of autoimmune diseases. As such, inhibiting chemokine signaling has been of keen interest for the development of therapeutic ag
Externí odkaz:
https://doaj.org/article/dc762b06602041d28f80fcd50dabb157
Autor:
Alessandro Angelini, Yoshishige Miyabe, Daniel Newsted, Byron H. Kwan, Chie Miyabe, Ryan L. Kelly, Misha N. Jamy, Andrew D. Luster, K. Dane Wittrup
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
CXCR2 antagonism has been shown to be anti-arthritic, but anti-chemokine therapies usually fail in the clinic owing to redundancy in chemokine-receptor interactions. Here the authors develop single-chain antibodies with multiple chemokine specificiti
Externí odkaz:
https://doaj.org/article/c0b1123a348f40e095ceb7693a617ee1
Autor:
K. Dane Wittrup, Michael T. Hemann, Christian J. Braun, Ryan L. Kelly, Alison W. Tisdale, Monique J. Kauke
Mutated in approximately 30% of human cancers, Ras GTPases are the most common drivers of oncogenesis and render tumors unresponsive to many standard therapies. Despite decades of research, no drugs directly targeting Ras are currently available. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43eee4f01b70dca9119d86936d6043a5
https://doi.org/10.1158/1535-7163.c.6537837.v1
https://doi.org/10.1158/1535-7163.c.6537837.v1
Autor:
K. Dane Wittrup, Michael T. Hemann, Christian J. Braun, Ryan L. Kelly, Alison W. Tisdale, Monique J. Kauke
Supplementary Figure S1. Cell lines constitutively express R11.1.6 or control proteins YW1 and EGFP. a, Flow cytometry histograms of human cancer cell lines A431, HT-29, LS180, and HPAF-II, transduced to constitutively express EGFP, R11.1.6 (and an E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3821b86b5e150248cb82275e07830ab9
https://doi.org/10.1158/1535-7163.22504734.v1
https://doi.org/10.1158/1535-7163.22504734.v1
Publikováno v:
American Journal of Case Reports. 23
BACKGROUND Chronic myeloid leukemia (CML) is a myeloproliferative malignancy generally treated with Dasatinib, a tyrosin-kinase inhibitor. Pleural effusions are a known adverse effect, but only 0.8% of patients develop pleural effusions after 6 years
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981b921e6cb7578b0a780f9f09692dcb
https://doi.org/10.12659/ajcr.938319
https://doi.org/10.12659/ajcr.938319
Autor:
Nicholas J. Agard, Peter S. Dragovich, Ryan L. Kelly, Shion A. Lim, Allison M. Beal, Ian Moench, Anna M. Gram, Pei-Pei Kung, Daša Lipovšek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35ae0feec8bc4e0efe319f5c4f279989
https://doi.org/10.29200/acsmedchemrev-v56.ch22
https://doi.org/10.29200/acsmedchemrev-v56.ch22
Autor:
Victoria P Rigsby, Derek Clewley, Meghan M Exline, Ryan L Kelly, Andrew P Statkevich, Daniel I. Rhon, Melissa C Minniti
Publikováno v:
The American Journal of Sports Medicine. 48:1773-1785
Background: The effectiveness of blood flow restriction training (BFRT) as compared with other forms of training, such as resistance training, has been evaluated in the literature in clinical and nonclinical populations. However, the safety of this i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f259d0aa041d06d3121c774f95459c
https://doi.org/10.1177/0363546519882652
https://doi.org/10.1177/0363546519882652
Autor:
Nishant Mehta, Robert B. Lee, John L. Silberstein, Louai Labanieh, Sean A. Hunter, Sainiteesh Maddineni, Amanda Lauren Rabe, Caitlyn L. Miller, Ryan L. Kelly, Jennifer R. Cochran, R Andres Parra Sperberg
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint that maintains peripheral T cell quiescence and inhibits anti-tumor immune responses. VISTA functions by dampening the interaction between myeloid cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db36293efb6560050533a9e0ef106c5c
http://europepmc.org/articles/PMC7494997
http://europepmc.org/articles/PMC7494997
Publikováno v:
mAbs
Efforts to develop effective antibody therapeutics are frequently hampered by issues such as aggregation and nonspecificity, often only detected in late stages of the development process. In this study, we used a high throughput cross-reactivity assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb63e794720305db14e5e6009c92231
https://doi.org/10.1080/19420862.2017.1356528
https://doi.org/10.1080/19420862.2017.1356528
Autor:
Doris Le, Jessie Zhao, Tushar Jain, K. Dane Wittrup, Jared Feldman, Monique J. Kauke, Ryan L. Kelly, James C. Geoghegan
Publikováno v:
mAbs
Early stage assays that evaluate monoclonal antibody drug-like properties serve as valuable tools for selection of lead candidates. One liability for clinical development, off-target reactivity, is often assessed by binding to a mixture or panel of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9673b2ae75056bf0b46f31b27bb4c2af
https://doi.org/10.1080/19420862.2017.1356529
https://doi.org/10.1080/19420862.2017.1356529