Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ryan Kuzmickas"'
Autor:
Amy E Schade, Ryan Kuzmickas, Carrie L Rodriguez, Kaia Mattioli, Miriam Enos, Alycia Gardner, Karen Cichowski
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002038 (2023)
While screening and early detection have reduced mortality from prostate cancer, castration-resistant disease (CRPC) is still incurable. Here, we report that combined EZH2/HDAC inhibitors potently kill CRPCs and cause dramatic tumor regression in agg
Externí odkaz:
https://doaj.org/article/cbbf2f8fe5bb48b684463c3b2ea4080e
Autor:
David L. Stern, Justin Crocker, Yun Ding, Nicolas Frankel, Gretchen Kappes, Elizabeth Kim, Ryan Kuzmickas, Andrew Lemire, Joshua D. Mast, Serge Picard
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 4, Pp 1339-1347 (2017)
Species of the Drosophila melanogaster species subgroup, including the species D. simulans, D. mauritiana, D. yakuba, and D. santomea, have long served as model systems for studying evolution. However, studies in these species have been limited by a
Externí odkaz:
https://doaj.org/article/65e8e7fb5e6f4b10a8fe166aa51be998
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7264 (2009)
Freshwater lakes and ponds present an ecological interface between humans and a variety of host organisms. They are a habitat for the larval stage of many insects and may serve as a medium for intraspecies and interspecies transmission of viruses suc
Externí odkaz:
https://doaj.org/article/fe84d31249a14832ac6ebd0a3ffb30b6
Autor:
Karen Cichowski, Stephen J. Elledge, Shailja Pathania, Keith T. Flaherty, Levi A. Garraway, Elodie Hatchi, Christian Bowman-Colin, Thomas De Raedt, Terence C. Wong, Caroline J. Guild, Alessandra G. Gavin, Chloe E. Emerson, Haley E. Manchester, Ryan Kuzmickas, Ophélia Maertens
Supplementary Tables 1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0effcf971400872c1a7839e9c4838839
https://doi.org/10.1158/2159-8290.22533134.v1
https://doi.org/10.1158/2159-8290.22533134.v1
Autor:
Karen Cichowski, Stephen J. Elledge, Shailja Pathania, Keith T. Flaherty, Levi A. Garraway, Elodie Hatchi, Christian Bowman-Colin, Thomas De Raedt, Terence C. Wong, Caroline J. Guild, Alessandra G. Gavin, Chloe E. Emerson, Haley E. Manchester, Ryan Kuzmickas, Ophélia Maertens
Supplementary Figures and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a6bfd6164f7f4e7b36e686fb19a1fb
https://doi.org/10.1158/2159-8290.22533128.v1
https://doi.org/10.1158/2159-8290.22533128.v1
Autor:
Keith T. Flaherty, Haley E. Manchester, Stephen J. Elledge, Thomas De Raedt, Caroline J. Guild, Levi A. Garraway, Terence C. Wong, Karen Cichowski, Chloe E. Emerson, Ryan Kuzmickas, Shailja Pathania, Christian Bowman-Colin, Alessandra G. Gavin, Elodie Hatchi, Ophélia Maertens
Publikováno v:
Cancer Discovery. 9:526-545
Although the majority of BRAF-mutant melanomas respond to BRAF/MEK inhibitors, these agents are not typically curative. Moreover, they are largely ineffective in NRAS- and NF1-mutant tumors. Here we report that genetic and chemical suppression of HDA
Autor:
Justin Crocker, Yun Ding, Nicolás Frankel, Elizabeth Kim, Gretchen Kappes, Serge Picard, David L. Stern, Ryan Kuzmickas, Joshua D. Mast, Andrew L. Lemire
Publikováno v:
G3: Genes|Genomes|Genetics
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
G3: Genes, Genomes, Genetics, Vol 7, Iss 4, Pp 1339-1347 (2017)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
G3: Genes, Genomes, Genetics, Vol 7, Iss 4, Pp 1339-1347 (2017)
Species of the Drosophila melanogaster species subgroup, including the species D. simulans, D. mauritiana, D. yakuba, and D. santomea, have long served as model systems for studying evolution. However, studies in these species have been limited by a
Autor:
Sandro Santagata, Karen Cichowski, Caroline J. Guild, Amanda J. Redig, Stephanie Guerra, Ophélia Maertens, Emily S. Chambers, Richard O. Adeyemi, Hong L. Tiv, Shawna Guillemette, Man Xu, Stephen J. Elledge, Thomas De Raedt, Ryan Kuzmickas, Pasi A. Jänne
Publikováno v:
Cancer cell. 37(5)
While KRAS mutations are common in non-small cell lung cancer (NSCLC), effective treatments are lacking. Here, we report that half of KRAS-mutant NSCLCs aberrantly express the homeobox protein HOXC10, largely due to unappreciated defects in PRC2, whi
Autor:
Ophélia Maertens, Ryan Kuzmickas, Haley Manchester, Chloe Emerson, Alessandra Gavin, Caroline Guild, Terence Wong, Thomas De Raedt, Christian Bowman-Colin, Elodie Hatchi, Levi Garraway, Keith Flaherty, Shailja Pathania, Stephen Elledge, Karen Cichowski
Publikováno v:
Cancer Research. 79:LB-113
While the majority of BRAF-mutant melanomas respond to BRAF/MEK inhibitors, these agents are not typically curative. Moreover, they are largely ineffective in NRAS and NF1-mutant tumors. Here we report that genetic and chemical suppression of HDAC3 p
Autor:
Appolinaire Djikeng, David J. Spiro, Jennifer A. Rathe, Claire M. Fraser-Liggett, Ryan Kuzmickas, Shiliang Wang, Stephen B. Liggett, Ann C. Palmenberg
Publikováno v:
Science. 324:55-59
Infection by human rhinovirus (HRV) is a major cause of upper and lower respiratory tract disease worldwide and displays considerable phenotypic variation. We examined diversity by completing the genome sequences for all known serotypes ( n = 99). Su