Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ryan Knihtila"'
Autor:
Monique J. Kauke, Michael W. Traxlmayr, Jillian A. Parker, Jonathan D. Kiefer, Ryan Knihtila, John McGee, Greg Verdine, Carla Mattos, K. Dane Wittrup
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are major drivers of oncogenesis and render tumors unresponsive to standard therapies. Here we
Externí odkaz:
https://doaj.org/article/2ce4911947be421fa5711cae0ecd11de
Autor:
Ryan, Knihtila, Letha, Chemmalil, Pranoti, Sawant, Sohil, Bhavsar, June, Kuang, Chun, Shao, Jennifer, Atsma, Zhengjian, Li, Julia, Ding
Publikováno v:
Journal of Chromatography B. 1212:123502
Monoclonal antibodies (mAbs) are complex glycoproteins that are developed for treatment of various therapeutic indications such as cancer and autoimmune diseases. MAbs are glycosylated at conserved asparagine residues (N-X-S/T) of the Fc region at am
Autor:
David Wang, Naresh Chennamsetty, Hannah R. Doss, Alan Shupe, Ryan Knihtila, Nesredin Mussa, Mathura Raman
Publikováno v:
Journal of Chromatography A. 1598:101-112
When developing purification processes for monoclonal antibodies (mAbs), ensuring the effective removal of high molecular weight (HMW) species is often challenging and labor intensive. In this work, we present a bottom-up characterization approach to
Publikováno v:
Acta Crystallogr F Struct Biol Commun
Neutron protein crystallography (NPC) reveals the three-dimensional structures of proteins, including the positions of H atoms. The technique is particularly suited to elucidate ambiguous catalytic steps in complex biochemical reactions. While NPC un
Autor:
Ryan Knihtila, Xin Zhang, Dhanuka P. Wasalathanthri, Letha Chemmalil, Sohil Bhavsar, Jay A. A. West, Jianlin Xu, Kyle P. McHugh, Neha Puri, June Kuang, Qin He, Chun Shao, Zheng Jian Li, Matthew S. Rehmann, Michael Borys, Tanushree Prabhakar, Julia Ding, Robin Barbour
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(9)
The biopharmaceutical industry is transitioning from currently deployed batch-mode bioprocessing to a highly efficient and agile next-generation bioprocessing with the adaptation of continuous bioprocessing, which reduces capital investment and opera
Autor:
Letha Chemmalil, Chun Shao, Sohil Bhavsar, June Kuang, Tanushree Prabhakar, Neha Puri, Jianlin Xu, Jay A. A. West, Matthew S. Rehmann, Michael Borys, Julia Ding, Zheng Jian Li, Qin He, Xin Zhang, Kyle P. McHugh, Ryan Knihtila, Dhanuka Wasalthanthri, Robin Barbour
The biopharmaceutical industry is transitioning from currently deployed batch-mode bioprocessing to a highly efficient and agile next generation bioprocessing with the adaptation of continuous bioprocessing, which reduces the capital investment and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c81bb14c632203892cb791de41e2d573
https://doi.org/10.22541/au.160977291.13543398/v1
https://doi.org/10.22541/au.160977291.13543398/v1
Publikováno v:
Journal of pharmaceutical sciences. 110(7)
Size Exclusion Chromatography (SEC) has been widely used to assess aggregate content in bio-pharmaceutical drugs such as monoclonal antibodies (mAbs), and is routinely used during method development and release testing. Electrostatic interactions bet
Autor:
Oliver Mikse, Tahirih L. Lamothe, Lisa M Olson, Nidhi Jain, Jennifer L. Proctor, Ryan Knihtila, Sean McDonough, John C. Davis, Anthony E. Boitano, Rahul Palchaudhuri, Michael P. Cooke, Ganapathy N. Sarma, Bradley R. Pearse, Prashant raj Bhattarai, Leanne Lanieri, Junia Dushime, Kellie Latimer
Publikováno v:
Transplantation and Cellular Therapy. 27:S49-S50
Autor:
Ryan Knihtila, Michael P. Cooke, Tahirih L. Lamothe, Leanne Lanieri, Sean McDonough, Anthony E. Boitano, Prashant raj Bhattarai, John C. Davis, Rahul Palchaudhuri, Junia Dushime, Jennifer L. Proctor, Oliver Miske, Nidhi Jain, Ganapathy N. Sarma, Bradley R. Pearse, Kellie Latimer
Publikováno v:
Blood. 136:47-48
Hematopoietic stem cell transplant (HSCT) can be a highly effective, and often curative, treatment for patients with AML. At present, myeloablative conditioning (MAC) regimens are associated with severe acute and long-term toxicities. A subset of tra
Autor:
Rahul Palchaudhuri, Junia Dushime, Jason Neale, Ganapathy N. Sarma, Bradley R. Pearse, Melissa L. Brooks, Charlotte Mcdonagh, Jennifer L. Proctor, Anthony E. Boitano, Tahirih L. Lamothe, Ryan Knihtila, Nidhi Jain, Rajiv Panwar, Qing Li, Sean McDonough, John C. Davis, Michael P. Cooke, Lena Kien, Kellie Latimer
Publikováno v:
Biology of Blood and Marrow Transplantation. 26:S35-S36
Current approaches to conditioning prior to transplant and gene therapy employ non-specific genotoxic agents that are associated with severe acute and long-term toxicities. Consequently, many transplant eligible patients either refuse transplant or r