Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ryan Kerrigan"'
Autor:
Natalie Dales, Monish Jain, Sanchez Carina Cristina, Ryan Kerrigan, Atwood K. Cheung, Cary Fridrich, Donovan N. Chin, Brian Hurley, Keith Hoffmaster, Lin Deng, Ronald Tomlinson, Marc Hild, Rajeev Sivasankaran, Jake Axford, Aleem Fazal, Gary O’Brien, Christopher Towler, Mailin Van Hoosear, Youngah Shin, Dione Kobayashi, Shen Yiping, Lei Shu, William F. Dietrich, Karen S. Chen, Lawrence G. Hamann, Karin Briner, Rebecca Servais, Cheng Song, Emma Cody, Robert Sun, Daniel Curtis, Moo Je Sung, Ying Hou
Publikováno v:
Journal of Medicinal Chemistry. 61:11021-11036
Spinal muscular atrophy (SMA), a rare neuromuscular disorder, is the leading genetic cause of death in infants and toddlers. SMA is caused by the deletion or a loss of function mutation of the survival motor neuron 1 (SMN1) gene. In humans, a second
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a86b835f8a7bec6e7356af0b03dae4
https://doi.org/10.1021/acs.jmedchem.8b01291
https://doi.org/10.1021/acs.jmedchem.8b01291
Autor:
Lili Xie, Charles R. Dean, Colin Osborne, Grazia Piizzi, Som Wattanasin, Jade Bojkovic, Francois Lenoir, Eugene Liu, Yipin Lu, Meir Glick, Donghui Yu, Tommasi Ruben A, Lawrence G. Hamann, Bing Wang, John Ryan Kerrigan, David Thomas Parker, Markus Dobler, Srijan Ranjitkar, JoAnn Dzink-Fox, Yunshan Peng, Leanne Lanieri, Hongming Wang, Xia Yang, David McKenney, Jill Nunez, Anup Patnaik, Maria-Dawn Lilly, Elizabeth R. Sprague
Publikováno v:
Journal of Medicinal Chemistry. 60:5002-5014
Over the past several decades, the frequency of antibacterial resistance in hospitals, including multidrug resistance (MDR) and its association with serious infectious diseases, has increased at alarming rates. Pseudomonas aeruginosa is a leading cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094ae843eba8c8bf8c94ae8350980ced
https://doi.org/10.1021/acs.jmedchem.7b00377
https://doi.org/10.1021/acs.jmedchem.7b00377
Autor:
JoAnne Dzink-Fox, Jason T. Brewer, Esther K. Schmitt, Karl Dean, Matthew J. LaMarche, Stacey Tiamfook, Gabe Gamber, Zachary Robinson, Jennifer A. Leeds, Michael A. Patane, Deborah Palestrant, Colin Osborne, Franco Lombardo, Akash K. Jain, David McKenney, Jian Ding, Lewis Whitehead, Philipp Krastel, Elin M. Rann, Travis Stams, Donghui Yu, Ryan Kerrigan, Georg Neckermann, Kwangho Lee
Publikováno v:
Journal of medicinal chemistry. 59(14)
Synthetic studies of the antimicrobial secondary metabolite thiomuracin A (1) provided access to analogues in the Northern region (C2–C10). Selective hydrolysis of the C10 amide of lead compound 2 and subsequent derivatization led to novel carbon-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e6e2e5b9088dc74bc09de581c51bc2
https://pubmed.ncbi.nlm.nih.gov/27355833
https://pubmed.ncbi.nlm.nih.gov/27355833
Autor:
Lawrence G. Hamann, John Ryan Kerrigan, Buck L. H. Taylor, Hasnain A. Malik, Kendall N. Houk, Jonathan E. Grob, Andrew Patterson, J. Du Bois
Publikováno v:
Chemical Science. 5:2352
We outline a strategy to enable non-directed Pd(II)-catalyzed C–H functionalization in the presence of Lewis basic heterocycles. In a high-throughput screen of two Pd-catalyzed C–H acetoxylation reactions, the addition of a variety of N-containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd54936b29b0b6ccde1c19373f9d3636
https://doi.org/10.1039/c3sc53414f
https://doi.org/10.1039/c3sc53414f