Development of non-sedating benzodiazepines with in vivo antischistosomal activity.

Autor: Mian MY; Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.; Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Sharmin D; Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.; Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Mondal P; Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.; Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Belayet JB; Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.; Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Hossain MM; Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.; Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., McCusker P; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Ryan KT; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Fedorov AY; UW Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Green HA; UW Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Ericksen SS; UW Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Zamanian M; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Tiruveedhula VVNPB; Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Cook JM; Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.; Milwaukee Institute of Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Chan JD; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Chemistry, University of Wisconsin Oshkosh, Oshkosh, Wisconsin, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Sep 04; Vol. 68 (9), pp. e0036924. Date of Electronic Publication: 2024 Aug 13.

Nemacol is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter with anthelmintic potential.

Autor: Harrington S; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada.; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada., Pyche J; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada.; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada., Burns AR; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada., Spalholz T; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, 04318, Leipzig, Germany., Ryan KT; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Baker RJ; The Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada., Ching J; The Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada., Rufener L; INVENesis Sàrl, Route de Neuchâtel 15A, 2072, St Blaise (NE), Switzerland., Lautens M; The Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada., Kulke D; Research Parasiticides, Bayer Animal Health GmbH, Monheim, Germany.; Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA.; Global Innovation, Boehringer Ingelheim Vetmedica GmbH, Binger Str. 173, 55218, Ingelheim am Rhein, Germany., Vernudachi A; INVENesis France Sàrl, 147 Avenue André Maginot, Tours, 37100, France., Zamanian M; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Deuther-Conrad W; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, 04318, Leipzig, Germany., Brust P; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, 04318, Leipzig, Germany.; The Lübeck Institute of Experimental Dermatology, University Medical Center Schleswig-Holstein, 23562, Lübeck, Germany., Roy PJ; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada. peter.roy@utoronto.ca.; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada. peter.roy@utoronto.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. peter.roy@utoronto.ca.

Publikováno v: Nature communications [Nat Commun] 2023 Mar 31; Vol. 14 (1), pp. 1816. Date of Electronic Publication: 2023 Mar 31.

Multivariate chemogenomic screening prioritizes new macrofilaricidal leads.

Autor: Wheeler NJ; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.; Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, WI, USA., Ryan KT; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Gallo KJ; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Henthorn CR; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Ericksen SS; Small Molecule Screening Facility, Drug Development Core, UW-Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Chan JD; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.; Department of Chemistry, University of Wisconsin-Oshkosh, Oshkosh, WI, USA., Zamanian M; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA. mzamanian@wisc.edu.

Publikováno v: Communications biology [Commun Biol] 2023 Jan 13; Vol. 6 (1), pp. 44. Date of Electronic Publication: 2023 Jan 13.

Increased dietary calcium inclusion in fully acidified prepartum diets improved postpartum uterine health and fertility when fed to Holstein cows.

Autor: Ryan KT; Department of Animal Sciences, University of Illinois, Urbana, IL, USA., Guadagnin AR; Department of Animal Sciences, University of Illinois, Urbana, IL, USA., Glosson KM; Department of Animal Sciences, University of Illinois, Urbana, IL, USA; Phibro Animal Health Corporation, Teaneck, NJ, USA., Bascom SS; Phibro Animal Health Corporation, Teaneck, NJ, USA., Rowson AD; Phibro Animal Health Corporation, Teaneck, NJ, USA., Steelman AJ; Department of Animal Sciences, University of Illinois, Urbana, IL, USA., Cardoso FC; Department of Animal Sciences, University of Illinois, Urbana, IL, USA. Electronic address: cardoso2@illinois.edu.

Publikováno v: Theriogenology [Theriogenology] 2020 Jan 15; Vol. 142, pp. 338-347. Date of Electronic Publication: 2019 Oct 15.