Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ryan K. Spencer"'
Autor:
Leah T. Roe, Andy I. Nguyen, Glenn L. Butterfoss, Andrew W. Wijaya, Ronald N. Zuckermann, Nan Li, Ryan K. Spencer
Publikováno v:
Journal of the American Chemical Society. 141:19436-19447
Sequence-defined peptoids, or N-substituted glycines, are an attractive class of bioispired polymer due to their biostability and efficient synthesis. However, the de novo design of folded peptoids...
Autor:
Ronald N. Zuckermann, Ryan K. Spencer, Xi Jiang, Nan Li, Nitash P. Balsara, Sunting Xuan, David Prendergast
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 45
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance A fundamental challenge in materials science is to understand the atomic-level structures of nanoarchitectures assembled from synthetic polymers. Here, we report a family of sequence-defined polypeptoids that form free-floating crystalli
Publikováno v:
ACS Chem Neurosci
High-resolution structures of oligomers formed by the β-amyloid peptide, Aβ, are important for understanding the molecular basis of Alzheimer's disease. Dimers of Aβ are linked to the pathogenesis and progression of Alzheimer's disease, and tetram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f97248191f5ec30e8321d21967638d
https://europepmc.org/articles/PMC7811405/
https://europepmc.org/articles/PMC7811405/
Autor:
Hannah S. Martin, Uyen N. T. Nguyen, Jacqueline Dang, Ronald N. Zuckermann, Parsa Asachi, Ryan K. Spencer
Publikováno v:
3D Printing and Additive Manufacturing, vol 7, iss 2
Three-dimensional (3D) models are essential for visualization and conceptual understanding of complex architectures such as protein structure. Although there is a plethora of software platforms that allow digital depictions of protein structure at an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268690c415d84357e2d99f5ea8d301b7
https://escholarship.org/uc/item/5b68h9r5
https://escholarship.org/uc/item/5b68h9r5
Autor:
Ryan K. Spencer, Ronald N. Zuckermann, Lisa Yun, Jae Hong Kim, Elissa M. Grzincic, Mark Kline
Publikováno v:
Soft matter. 16(4)
Biological systems have evolved sophisticated molecular assemblies capable of exquisite molecular recognition across length scales ranging from angstroms to microns. For instance, the self-organization of glycolipids and glycoproteins on cell membran
Autor:
Andrew W, Wijaya, Andy I, Nguyen, Leah T, Roe, Glenn L, Butterfoss, Ryan K, Spencer, Nan K, Li, Ronald N, Zuckermann
Publikováno v:
Journal of the American Chemical Society. 141(49)
Sequence-defined peptoids, or
Autor:
Ronald N. Zuckermann, Allon I. Hochbaum, Benjamin C. Hudson, Anant K. Paravastu, Glenn L. Butterfoss, Stephen Whitelam, Ryan K. Spencer, John R. Edison
Publikováno v:
Proceedings of the National Academy of Sciences. 115:5647-5651
Significance Commonly observed secondary structures of proteins, such as α -helices and β -sheets, are built from a trans- amide backbone with residues sampling a single region of the Ramachandran plot. Here we report a secondary structure displaye
Autor:
Michael D. Connolly, Anant K. Paravastu, Alessia Battigelli, Benjamin C. Hudson, John R. Edison, Ryan K. Spencer, Stephen Whitelam, Ronald N. Zuckermann
Publikováno v:
The Journal of Physical Chemistry Letters. 9:2574-2578
Peptoid nanosheets are supramolecular protein-mimetic materials that form from amphiphilic polypeptoids with aromatic and ionic side chains. Nanosheets have been studied at the nanometer scale, but the molecular structure has been difficult to probe.
Publikováno v:
ACS Nano. 12:2652-2661
Examples of long-range electronic conductivity are rare in biological systems. The observation of micrometer-scale electronic transport through protein wires produced by bacteria is therefore notable, providing an opportunity to study fundamental asp
Autor:
Imane L. Hamza, Ryan K. Spencer, Kate J. McKnelly, James S. Nowick, Adam G. Kreutzer, Stan Yoo, Patrick J. Salveson
Publikováno v:
Biochemistry
The absence of high-resolution structures of amyloid oligomers constitutes a major gap in our understanding of amyloid diseases. A growing body of evidence indicates that oligomers of the β-amyloid peptide Aβ are especially important in the progres