Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ryan K. Muir"'
Autor:
Ryan K. Muir, Ning Zhao, Junnian Wei, Yung-hua Wang, Anna Moroz, Yangjie Huang, Ying-Chu Chen, Renuka Sriram, John Kurhanewicz, Davide Ruggero, Adam R. Renslo, Michael J. Evans
Publikováno v:
ACS Central Science, Vol 5, Iss 4, Pp 727-736 (2019)
Externí odkaz:
https://doaj.org/article/8a1f8dc0392b4f1ca4cc2864af7b7b4e
Autor:
Vladimir Camarena, David W Sant, Tyler C Huff, Sushmita Mustafi, Ryan K Muir, Allegra T Aron, Christopher J Chang, Adam R Renslo, Paula V Monje, Gaofeng Wang
Publikováno v:
eLife, Vol 6 (2017)
It is widely accepted that cAMP regulates gene transcription principally by activating the protein kinase A (PKA)-targeted transcription factors. Here, we show that cAMP enhances the generation of 5-hydroxymethylcytosine (5hmC) in multiple cell types
Externí odkaz:
https://doaj.org/article/cb740e3e9cd14769a9739af54a035d72
Autor:
David Mavor, Kyle Barlow, Samuel Thompson, Benjamin A Barad, Alain R Bonny, Clinton L Cario, Garrett Gaskins, Zairan Liu, Laura Deming, Seth D Axen, Elena Caceres, Weilin Chen, Adolfo Cuesta, Rachel E Gate, Evan M Green, Kaitlin R Hulce, Weiyue Ji, Lillian R Kenner, Bruk Mensa, Leanna S Morinishi, Steven M Moss, Marco Mravic, Ryan K Muir, Stefan Niekamp, Chimno I Nnadi, Eugene Palovcak, Erin M Poss, Tyler D Ross, Eugenia C Salcedo, Stephanie K See, Meena Subramaniam, Allison W Wong, Jennifer Li, Kurt S Thorn, Shane Ó Conchúir, Benjamin P Roscoe, Eric D Chow, Joseph L DeRisi, Tanja Kortemme, Daniel N Bolon, James S Fraser
Publikováno v:
eLife, Vol 5 (2016)
Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance
Externí odkaz:
https://doaj.org/article/f3e8373dbc7b4012a1c82425c9fb49fb
Publikováno v:
ACS chemical biology. 17(2)
Abnormal enzyme expression and activity is a hallmark of many diseases. Activity-based diagnostics are a class of chemical probes that aim to leverage this dysregulated metabolic signature to produce a detectable signal specific to diseased tissue. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd81157e844659428ab3b35d8d5405b
https://pubmed.ncbi.nlm.nih.gov/35026106
https://pubmed.ncbi.nlm.nih.gov/35026106
Publikováno v:
ACS Infectious Diseases. 5:1366-1375
Iron is essential to all life, and competition for this vital nutrient is central to host-pathogen interactions during infection. The opportunistic Gram-negative pathogen Pseudomonas aeruginosa utilizes a diverse array of iron-acquisition strategies,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad038b41a2adac28bfc19a2288d4d80e
https://doi.org/10.1021/acsinfecdis.9b00057
https://doi.org/10.1021/acsinfecdis.9b00057
Autor:
Honglin Jiang, Ryan K. Muir, Ryan L. Gonciarz, Adam B. Olshen, Iwei Yeh, Byron C. Hann, Ning Zhao, Yung-hua Wang, Spencer C. Behr, James E. Korkola, Michael J. Evans, Eric A. Collisson, Adam R. Renslo
Publikováno v:
The Journal of experimental medicine. 219(4)
KRAS mutations drive a quarter of cancer mortality, and most are undruggable. Several inhibitors of the MAPK pathway are FDA approved but poorly tolerated at the doses needed to adequately extinguish RAS/RAF/MAPK signaling in the tumor cell. We found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f682ba33ca77424875d0b561df4ae558
https://pubmed.ncbi.nlm.nih.gov/35262627
https://pubmed.ncbi.nlm.nih.gov/35262627
Autor:
John C. Widen, Ruth Geiss-Friedlander, Berati Cerikan, Matthew Bogyo, Scott Lovell, Heeyoung Kim, Kas Steuten, Ryan K Muir, Ralf Bartenschlager, John M. Bennett, Brett M. Babin, Christoph Peters, Mirko Cortese, Christopher J. Neufeldt, Oguz Bolgi, Ouma Onguka
Publikováno v:
ACS Infectious Diseases
Two proteases produced by the SARS-CoV-2 virus, Mproand PLpro, are essential for viral replication and have become the focus of drug development programs for treatment of COVID-19. We screened a highly focused library of compounds containing covalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fb6b93eff1b1816897bfc961c285f8
https://hdl.handle.net/11591/487230
https://hdl.handle.net/11591/487230
Autor:
Davide Ruggero, Michael J. Evans, Ryan K Muir, Pavithra Viswanath, Youngho Seo, Yangjie Huang, Junnian Wei, Ying-Chu Chen, Adam R. Renslo, Nima Hooshdaran, Ning Zhao, Yung-hua Wang
Publikováno v:
J Nucl Med
Background: Although cancer has been known for decades to harbor an insatiable appetite for iron, only recently has the chemistry emerged to exploit this altered state therapeutically, by targeting the expanded cytosolic ‘labile’ iron pool (LIP),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167235380f91f435b340cc2dd229c344
https://pubmed.ncbi.nlm.nih.gov/33246980
https://pubmed.ncbi.nlm.nih.gov/33246980
Autor:
Eric A. Collisson, Ryan K Muir, Adam R. Renslo, Yung-hua Wang, Spencer C. Behr, Byron Hann, Honglin Jiang, Iwei Yeh, Ning Zhao, Ryan L. Gonciarz, Michael J. Evans, Adam B. Olshen
Publikováno v:
SSRN Electronic Journal.
KRAS mutations cause a quarter of cancer mortality and currently are not sensitive to any targeted, FDA-approved agents. Several inhibitors of the MAPK pathway are FDA approved but exhibit low clinical tolerability at doses needed to adequately extin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9acca5eab6fdf586cd7ec9955e927c24
https://doi.org/10.2139/ssrn.3581366
https://doi.org/10.2139/ssrn.3581366
Autor:
Brian R, Blank, Poulami, Talukder, Ryan K, Muir, Erin R, Green, Eric P, Skaar, Adam R, Renslo
Publikováno v:
ACS Infect Dis
Iron is essential to all life, and competition for this vital nutrient is central to host–pathogen interactions during infection. The opportunistic Gram-negative pathogen Pseudomonas aeruginosa utilizes a diverse array of iron-acquisition strategie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbbb2acb5b6b1e6c418d1dbcbc4bb76d
https://pubmed.ncbi.nlm.nih.gov/31140267
https://pubmed.ncbi.nlm.nih.gov/31140267