Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ryan K. Mitchell"'
Autor:
Andrei I. Tarasov, Marco Bugliani, Matthew C. Cane, Natalie R. Johnston, Guy A. Rutter, Stephen J. Hughes, Shahab Haghollahi, Silvia Gimeno Brias, Domenico Bosco, Piero Marchetti, David J. Hodson, Ryan K. Mitchell, Paul Johnson
Publikováno v:
Molecular Endocrinology, Vol. 28, No 6 (2014) pp. 860-71
Molecular Endocrinology
Molecular Endocrinology
Incretins such as glucagon-like peptide 1 (GLP-1) are released from the gut and potentiate insulin release in a glucose-dependent manner. Although this action is generally believed to hinge on cAMP and protein kinase A signaling, up-regulated beta ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdeaacc081a4d9dae06a921efeb1ba38
https://doi.org/10.1210/me.2014-1038
https://doi.org/10.1210/me.2014-1038
Autor:
E. A. Bellomo, Wolfgang Maret, David J. Hodson, Antonia Solomou, Ming Hu, Guy A. Rutter, Ryan K. Mitchell, Pauline Chabosseau
Publikováno v:
The Proceedings of the Nutrition Society. 75(1)
Zinc is an important micronutrient, essential in the diet to avoid a variety of conditions associated with malnutrition such as diarrhoea and alopecia. Lowered circulating levels of zinc are also found in diabetes mellitus, a condition which affects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f794c89dfb959eaedfa782d37f501771
https://pubmed.ncbi.nlm.nih.gov/26365743
https://pubmed.ncbi.nlm.nih.gov/26365743
Autor:
Ryan K. Mitchell, Natalie R. Johnston, Johannes Broichhagen, K. Šmid, James A. Frank, Dirk Trauner, David J. Hodson, Piero Marchetti, Marco Bugliani, Guy A. Rutter
Publikováno v:
Chemical communications (Cambridge, England). 51(27)
Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illuminati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b30ee464edfe1aac502a4ff91786d62
https://pubmed.ncbi.nlm.nih.gov/25744824
https://pubmed.ncbi.nlm.nih.gov/25744824
Autor:
Stephen J. Hughes, Guy A. Rutter, Lorella Marselli, Vanessa Lavallard, David J. Hodson, Daliang Li, Piero Marchetti, Ryan K. Mitchell, Katy L. Everett, Francesca Semplici, Timothy J. Pullen, Wen Hong Li, Marco Bugliani, Silvia Gimeno Brias, Dermot M.F. Cooper, Lorenzo Piemonti, Paul Johnson, Domenico Bosco, A. M. James Shapiro
Publikováno v:
Diabetes
Diabetes, Vol. 63, No 9 (2014) pp. 3009-21
Hodson, D J, Mitchell, R K, Marselli, L, Pullen, T J, Gimeno Brias, S, Semplici, F, Everett, K L, Cooper, D M F, Bugliani, M, Marchetti, P, Lavallard, V, Bosco, D, Piemonti, L, Johnson, P R, Hughes, S J, Li, D, Li, W-H, Shapiro, A M J & Rutter, G A 2014, ' ADCY5 couples glucose to insulin secretion in human islets ', Diabetes, vol. 63, no. 9, pp. 3009-3021 . https://doi.org/10.2337/db13-1607
Diabetes, Vol. 63, No 9 (2014) pp. 3009-21
Hodson, D J, Mitchell, R K, Marselli, L, Pullen, T J, Gimeno Brias, S, Semplici, F, Everett, K L, Cooper, D M F, Bugliani, M, Marchetti, P, Lavallard, V, Bosco, D, Piemonti, L, Johnson, P R, Hughes, S J, Li, D, Li, W-H, Shapiro, A M J & Rutter, G A 2014, ' ADCY5 couples glucose to insulin secretion in human islets ', Diabetes, vol. 63, no. 9, pp. 3009-3021 . https://doi.org/10.2337/db13-1607
Single nucleotide polymorphisms (SNPs) within the ADCY5 gene, encoding adenylate cyclase 5, are associated with elevated fasting glucose and increased type 2 diabetes (T2D) risk. Despite this, the mechanisms underlying the effects of these polymorphi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e1e868ddcf2a6b7c6b12310e058850
https://pubmed.ncbi.nlm.nih.gov/24740569
https://pubmed.ncbi.nlm.nih.gov/24740569
Autor:
Michael Watkinson, Ekaterine Berishvili, Maria R. Paiva Pessoa, Guy A. Rutter, Marco Bugliani, Elizabeth Haythorne, Philip Duncanson, Jorge Ferrer, Lorenzo Piemonti, Domenico Bosco, Dirk Trauner, David J. Hodson, Johannes Broichhagen, Piero Marchetti, Natalie R. Johnston, Ryan K. Mitchell, Francesca Semplici
Publikováno v:
Cell Metabolism, Vol. 24, No 3 (2016) pp. 389-401
Cell Metabolism
Cell Metabolism
Summary The arrangement of β cells within islets of Langerhans is critical for insulin release through the generation of rhythmic activity. A privileged role for individual β cells in orchestrating these responses has long been suspected, but not d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f19e79a0ef3828d155a81b5d126dfd