Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ryan K. Kim"'
Autor:
Monica M. Olcina, Ryan K. Kim, Nikolas G. Balanis, Caiyun Grace Li, Rie von Eyben, Thomas G. Graeber, Daniel Ricklin, Manuel Stucki, Amato J. Giaccia
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101594- (2020)
Summary: The importance of innate immunity in cancer is increasingly being recognized with recent reports suggesting tumor cell-intrinsic intracellular functions for innate immunity proteins. However, such functions are often poorly understood, and i
Externí odkaz:
https://doaj.org/article/64c2b7db01984770a3fda8aeaa8c2c2f
Autor:
Monica M. Olcina, Nikolas G. Balanis, Ryan K. Kim, B. Arman Aksoy, Julia Kodysh, Michael J. Thompson, Jeff Hammerbacher, Thomas G. Graeber, Amato J. Giaccia
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3721-3732.e6 (2018)
Summary: Complement-mediated cytotoxicity may act as a selective pressure for tumor overexpression of complement regulators. We hypothesize that the same selective pressure could lead to complement alterations at the genetic level. We find that, when
Externí odkaz:
https://doaj.org/article/43f706b039384f6aa667af346e276ebc
Autor:
Callum Beach, David MacLean, Dominika Majorova, Stavros Melemenidis, Dhanya K. Nambiar, Ryan K. Kim, Gabriel N Valbuena, Silvia Guglietta, Carsten Krieg, Damavandi Mahnaz Darvish, Tatsuya Suwa, Alistair Easton, Enric Domingo, Eui Jung Moon, Dadi Jiang, Yanyan Jiang, Albert C Koong, Trent M. Woodruff, Edward E. Graves, Tim Maughan, Simon J. A. Buczacki, Manuel Stucki, Quynh-Thu Le, Simon J. Leedham, Amato J. Giaccia, Monica M Olcina
An immunosuppressive microenvironment causes poor tumour T-cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumours is still a challenge. Using an integrated s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::067c11b230c8c3a656c28cd8e2962f11
https://doi.org/10.1101/2023.01.10.521547
https://doi.org/10.1101/2023.01.10.521547
Autor:
Ryan K. Kim, Amato J. Giaccia, Monica M. Olcina, Jeff Hammerbacher, Julia Kodysh, Michael Thompson, Nikolas G. Balanis, Thomas G. Graeber, B. Arman Aksoy
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3721-3732.e6 (2018)
Cell reports
Cell reports
Complement-mediated cytotoxicity may act as a selective pressure for tumor overexpression of complement regulators. We hypothesize that the same selective pressure could lead to complement alterations at the genetic level. We find that, when analyzed
Autor:
Yu Xu, Karlene A. Cimprich, Ryan K. Kim, Anh N. Diep, Caiyun G. Li, Kaushik N. Thakkar, Yiren Xiao, Julien Bacal, Amato J. Giaccia, Eui Jung Moon, Joshua Bloomstein, Erinn B. Rankin, Joshua C. Saldivar, Quynh-Thu Le, Manal Mehibel
Publikováno v:
J Clin Invest
Hypoxia, a hallmark feature of the tumor microenvironment, causes resistance to conventional chemotherapy, but was recently reported to synergize with poly(ADP-ribose) polymerase inhibitors (PARPis) in homologous recombination-proficient (HR-proficie
Autor:
Ryan K. Kim, Amato J. Giaccia, Monica M. Olcina, Trent M. Woodruff, Rie von Eyben, Quynh-Thu Le, Kerriann M. Casey, Stavros Melemenidis, Edward G Graves, Manuel Stucki, Dhanya Nambiar
Engaging innate immune pathways is emerging as a productive way of achieving durable anti-tumor responses. However, systemic administration of these therapies can result in toxicity, deemed to be particularly problematic when combined with current st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::165dd1af5d6986fe4aab2598d4656786
https://doi.org/10.1101/2020.10.27.358036
https://doi.org/10.1101/2020.10.27.358036
Autor:
Nikolas G. Balanis, Monica M. Olcina, Ryan K. Kim, Daniel Ricklin, Manuel Stucki, Thomas G. Graeber, Amato J. Giaccia, Caiyun G. Li, Rie von Eyben
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101594-(2020)
iScience
iScience
Summary The importance of innate immunity in cancer is increasingly being recognized with recent reports suggesting tumor cell-intrinsic intracellular functions for innate immunity proteins. However, such functions are often poorly understood, and it
Publikováno v:
The British Journal of Radiology
The British journal of radiology, vol 92, iss 1093
The British journal of radiology, vol 92, iss 1093
The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated p
Autor:
Nikolas G. Balanis, Ryan K. Kim, Monica M. Olcina, Amato J. Giaccia, Thomas G. Graeber, Michael Thompson
Publikováno v:
Cancer Immunology Research. 7:A097-A097
The complement system has been proposed to facilitate cancer hallmarks such as increased metastatic potential, proliferation and apoptosis evasion. Despite the association between complement and tumor progression, a detailed characterization of cance
Autor:
Thomas G. Graeber, Nikolas G. Balanis, Ryan K. Kim, Monica M. Olcina, Michael Thompson, Amato J. Giaccia
Publikováno v:
Cancer Research. 78:4382-4382
The complement system is an important pathway in immunity. When dysregulated in the tumor microenvironment, complement is associated with suppression of antitumor immunity and tumorigenesis promotion. While complement has been reported to have import